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To take advantage of the information emerging from the mouse genome sequencing efforts, it has become necessary to systematically collect normative phenotypic information at all biological levels. Accordingly, an international collaboration, the Mouse Phenome Database (MPD) project, was created to establish a collection of baseline phenotypic data from commonly used inbred mice, such as the C57BL/6J, 129S1/SvlmJ, DBA/2J and BALB/cByJ strains.

The National Institutes of Health (NIH) neuroimaging phenotyping informatics emphasis has similarly been directed toward designing comprehensive three dimensional (3D) digital brain atlases of commonly used mice strains including variability of brain structures across a given strain.

As part of this world-wide effort, we have constructed an adult male C57BL/6J mouse brain atlas database derived directly from T2*-weighted 3D magnetic resonance microscopy images acquired on a 17.6-T magnet @ University of Florida. The 3D neuroanatomical information of twenty segmented structures including structure variability data, are integrated into a comprehensive database with the following framework:

  • Multiple brain samples with T2*-weighted 3D magnetic resonance microscopy images.
  • Individual 3D digital anatomical atlases and associated quantitative structural information.
  • Probabilistic atlases.
  • Minimal Deformation (Average Shape) Atlas.
  • Downloadable visualization tool.

This development, although lacking the histological resolution of traditional mouse brain atlases, is intended to circumvent the shortcomings of currently available 2D and 3D atlases and to provide new quantitative anatomical information as well as additional computational templates for integrating other related information such as function and gene expression patterns.

For more details about this database, please see:

Ma Y, Hof PR, Grant SC, Blackband SJ, Bennett R, Slatest L, McGuigan MD, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience. 2005;135(4):1203-15

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Last Modified: Nov. 2005

 


DOE, Office of ScienceOne of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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