Stephen L. Dewey, Senior Chemist, Brookhaven National Lab

Research Interests: Neurotransmitter interactions in healthy and diseased states, functional regulation of neurotransmitter systems, behavioral pharmacology and animal models of addiction, in vivo neurochemical monitoring techniques (microdialysis, PET, and microPET)

Telephone: 631-344-4395
e-mail: sld@bnl.gov

B.S. Fairleigh Dickinson University, 1981;
Ph.D. University of Iowa, 1985

Postdoctoral Fellow, Department of Neurology, State University of New York, Stony Brook, 1985-1986;
Assistant Chemist, Brookhaven National Laboratory, 1986-1988;
Associate Chemist, BNL, 1988-1991;
Chemist, continuing, BNL, 1991-1995;
Tenured Scientist, BNL, 1995-present;
Senior Chemist, 1998-Present,
Research Professor of Psychiatry, NYU School of Medicine,
Adjunct Professor of Neurobiology and Behavior, SUNY at Stony Brook

Selected Publications

Wynne K Schiffer, Jean Logan, and Stephen L Dewey. Positron Emission Tomography Studies of Potential Mechanisms Underlying Phencyclidine-Induced Alterations in Striatal Dopamine. Neuropsychopharmacology, Jul 2003.

WK Schiffer, D Marsteller, and SL Dewey. Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine. Psychopharmacology (Berl), Jul 2003; 168(3): 339-43.

WK Schiffer, M Azmoodeh, M Gerasimov, ND Volkow, JS Fowler, and SL Dewey. Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine. Synapse, Apr 2003; 48(1): 35-8.

MR Gerasimov, J Logan, RA Ferrieri, RD Muller, D Alexoff, and SL Dewey
Effect of vehicle on brain uptake of [11C]toluene. Nucl Med Biol, Jul 2002; 29(5): 607-12.

CR Ashby Jr, M Paul, EL Gardner, MR Gerasimov, SL Dewey, IC Lennon, and SJ Taylor
Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats. Synapse, May 2002; 44(2): 61-3.

MR Gerasimov, RA Ferrieri, WK Schiffer, J Logan, SJ Gatley, AN Gifford, DA Alexoff, DA Marsteller, C Shea, V Garza, P Carter, P King, CR Ashby Jr, S Vitkun, and SL Dewey
Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice. Life Sci, Apr 2002; 70(23): 2811-28.

MR Gerasimov, WK Schiffer, D Marstellar, R Ferrieri, D Alexoff, and SL Dewey
Toluene inhalation produces regionally specific changes in extracellular dopamine. Drug Alcohol Depend, Feb 2002; 65(3): 243-51.

Ashby CR, Horan B, Schiffer WK, Brodie JD, Dewey SL and Gardner, EL. (2001) Gamma-vinyl GABA (GVG) an irreversible inhibitor of GABA transaminase, attenuates cocaine-induced sensitization in rats. J Pharm Exp Ther (in press)

Gerasimov MR, Schiffer WK, Marsteller DA, Ferrieri R, and Dewey SL. (2001) Psychostimulants modulate toluene’s effects on NAcc and PFC dopamine. Drug Alcohol Depend (in press)

Schiffer WK, Gerasimov MR, Marsteller DA, Ashby CR, Brodie JD and Dewey SL. (2001). Topiramate selectively attenuates nicotine-induced increases in monoamine release. Eur J Pharm (in press)

Gerasimov MR, Franceschi M, Volkow ND, Rice O, Schiffer WK & Dewey SL. (2000) Synergistic interactions between nicotine and cocaine on methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse 38: 432-437

Gerasimov MR, Schiffer WK, Marsteller DA, Ashby C, Gardner EL, Lennon IC, Taylor S, Brodie JB, Dewey SL. (2001) GABAergic blockade of cocaine-associated cue-induced increase in nucleus accumbens dopamine. Eur J Pharm 414: 205-209.

Schiffer WK, Gerasimov MR, Brodie JD, Logan J, Fowler JS, Ashby CR, Alexoff DL and Dewey SL. (2001) g-vinyl GABA modulates striatal NMDA antagonist-induced dopamine release: A PET investigation in non-human primates. Psychopharmacology (in press)

Last Modified: February 22, 2008