Richard B. Setlow
Senior Biophysicist Emeritus,
Member of the National Academy
Brookhaven National Laboratory
Bldg. 463 - P.O. Box 5000
Upton, NY 11973-5000
Biochemistry and Cell Biology Department,
Stony Brook University
Richard Setlow Honored at Celebration Symposium
We do research on DNA damages, DNA repair, mutagenesis and carcinogenesis.
We have developed a fish model - a backcross hybrid of Xiphophorus strains -
that are exquisitely sensitive to light-induced melanoma, presumably because
the hybrids have only one tumor suppressor gene for melanoma. Single, acute
exposures to monochromatic light of wavelengths between 302-540 nm inactivate
the gene and result in melanomas. These fish are the only useful model for
human melanoma. Extrapolation of the data to sunlight exposures indicates
that the most effective wavelengths are >320 nm. Such wavelengths are not
significantly attenuated by sunscreens. We suspect that black pigment melanin
acts as a photosensitizer and results in photoproducts in DNA that inactivate
the suppressor gene. We are attempting to identify the photoproducts in
light-exposed human melanoma cells containing melanin.
In collaboration with Marine Scientists at SUNY, Stony Brook, and the
University of Georgia, we used transgenic medaka fish (Oryzias latipes)
to find the presence of mutagenic compounds in sediments around Long
Island Sound. We collaborate with Japanese scientists to assess the
mutagenic potential of high atomic number, high energy nuclei in
cosmic rays. These nuclei pose a risk to astronauts traveling beyond
low Earth orbits.
Dick Setlow is a member of the National Academy of Sciences and has received
prestigious awards from the Comité International de Photobiologie, the
Department of Energy, and the Enviromnental Mutagen Society. After 12 years
as Associate Director and 2 years as Acting Associate Director for Life
Sciences as well as 7 years as Chairman of the Biology Department, Dick
returned to more active research in 1998. See the story in the
Brookhaven Bulletin Vol.52 No.30 of July 31, 1998.
Results of recent work on the effects of cosmic radiation on spacetravelers
are reported in a 2005 publication and are summarized in the
BNL Press Release of April 14, 2005:
'Astronauts' Children Unlikely to Inherit Cosmic Ray-Induced Genetic Defects'.
The most recent work, PNAS (Jan.15,2008), shows that increased sun exposure may
lead to improved cancer prognosis as a result of Vitamin D synthesis rather
than skin cancer incidence
A hybrid Xiphophorus with melanoma on dorsal fin.
The fish is about 3cm long.
Moan J., Porojinicu A.C., Dahlback A. and Setlow R.B.
Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure.
Proc Natl Acad Sci USA, 105(2): 668-673 (2008).
Solar radiation and induction of DNA damages, mutations and skin cancers.
Solar Radiation and Human Health, E. Bjertness, Editor, pp. 137-146, Oslo: The Norwegian Academy of Sciences and Letters (2008).
Solar Radiation and Human Health Symposium, Oslo, Norway, May 10-11, 2007.
Wood S.R., Berwick M., Ley R.D., Walter R.B., Setlow R.B. and Timmins G.S.
UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production.
Proc Natl Acad Sci USA, 103:4111-4115 (2006).
Shimada A., Shima A., Nojima K., Seino Y. and. Setlow R.B
Germ cell mutagenesis in medaka fish after exposures to high-energy cosmic ray nuclei: A human model.
Proc Natl Acad Sci USA, 102(17):6063-6067 (2005).
Historical Reflections: A second life in science--working after the age of 65.
DNA Repair (Amst), 3(4):441-449 (2004).
Shedding light on proteins, nucleic acids, viruses, cells, humans and fish.
Mutat Res., 511:1-14 (2002).
The U.S. National Research Council's view of the radiation hazards in space.
Mutat Res., 430:169-175 (1999).
Spectral regions contributing to melanoma: a personal view.
J Investig Dermatol Symp Proc., 4:46-49 (1999).
Historical Review. DNA damage and repair: A photobiological odyssey.
Photochem Photobiol., 65S:1195-1225 (1997).
Relevance of in vivo models in melanoma skin cancer.
Photochem Photobiol., 63:410-412 (1996).
Bender M.A. and Setlow R.B.
Distributions of spontaneous chromosomal aberrations and of
spontaneous and induced SCE and micronuclei in peripheral lymphocytes
from a human population.
in: Proc Second Intl Symp on Chromosomal Aberrations
(AT Natarajan and G Obe, edts) pp 280-290, Springer Verlag, Berlin, Germany (1994).
Setlow R.B., and Woodhead A.D.
Temporal changes in the incidence of malignant melanoma: explanation from action spectra.
Mutat. Res., 307:365-374 (1994).
Setlow R.B., Grist E., Thompson K. and Woodhead A.D.
Wavelengths effective in induction of malignant melanoma.
Proc Natl Acad Sci USA, 90:6666-6670 (1993).
Full Text (pdf)
Awa A.A., Miller R.C., Parry D.M., Mulvihill J.J. and Beebe G.W.
Radiosensitivity of skin fibroblasts from atomic bomb survivors with
and without breast cancer.
Cancer Research, 50:4050-4055 (1990).
Hart RW, RB Setlow, and AD Woodhead.
Evidence that pyrimidine dimers in DNA can give rise to tumors.
Proc Natl Acad Sci USA, 74:5574-5578 (1977).
Full Text (pdf)
Setlow RB, and WC Carrier.
The disappearance of thymine dimers from DNA: An error-correcting mechanism.
Proc Natl Acad Sci USA, 51:226-231 (1964).
Full Text (pdf)
Last Modified: October 2, 2012
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