Other Info

Howard Robinson

Brookhaven National Laboratory
Bldg. 463 - P.O. Box 5000
Upton, NY 11973-5000

Phone:	(631) 344-4789
Fax:	(631) 344-2741
email:	hhr@bnl.gov

The Group:
Neil Whalen	(631) 344-7444

Howard Robinson is a beam line scientist in the Macromolecular Crystallography Research Resource (PXRR) which provides facilities and support at the National Synchrotron Light Source for the benefit of outside and in-house investigators. The PXRR is supported by the NIH's National Center for Research Resources and the DOE Office of Biological and Environmental Research in its mission to create optimal facilities and environments for macromolecular structure determination by synchrotron X-ray diffraction. With a staff of about 24, the PXRR innovates new access modes such as FedEx crystallography, builds new facilities, currently on the X25 undulator, advances automation, develops remote participation software, collaborates with outside groups, teaches novice users, and supports visting investigators with 7day, 20 hours staff coverage.

Research Interests

High throughput x-ray crystallography: Improvements in data collection at synchrotron sites, and simplified analysis of structures determined from MAD data. Bio-structure engineering: Protein mechanical engineering, high temperature stabilization of proteins, swapping of catalytic assemblies into new proteins. Cryo-electron microscopy: Techniques for interpretation of low resolution structures with high resolution derived structural information.

Howard Robinson's group focuses on facilitating access to synchrotrons for a broad spectrum of Biology and Biotechnology research scientists. Training is the primary tool used to provide this expanded access, and this training is a combination of experience at the beamline and also web-based training tutorials.

The group also provides a Mail-in X-ray Crystallographic Service with extremely rapid turn-around time, typically about two weeks. He carries out his research at several of the PXRR beamlines.
The innovative 'FedEx' synchrotron access mode pioneered by the PXRR group several years ago was recently highlighted in a
Nature News Feature (Nature 243, 799-800 (2003)) on 'Structural Biology: The crystal's in the mail...'. See also the Brookhaven Bulletin of July 11, 2003 (Vol 57 No 23).
Click above for Nature
feature in pdf format.

Selected Publications

Note: The PDB files below can be viewed with

Bernhards R.C., Jing X., Vogelaar N.J., Robinson H., and Schubot F.D.
Structural evidence suggests that antiactivator EXsD from Pseudomonas aeruginosa is a DNA binding protein.
Protein Science, 18(3):503-513 (March, 2009). PubMed
Brandao, T. A. S., Robinson H., Johnson, S. J., and Hengge, A. C.
Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
Journal of the American Chemical Society, 131(2):778-786 (January, 2009). PubMed
Buchko, G. W., Robinson H., and Addlagatta, A.
Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family.
Biochimica et Biophysica Acta ,1794(4):627-633 (April, 2009). PubMed
Gallagher, D. T., Smith, N., Kim, S.-K., Robinson H., and Reddy, P. T.
Profound asymmetry in the structure of the cAMP-free cAMP receptor protein (CRP) from Mycobacterium tuberculosis.
Journal of Biological Chemistry, 284(13):8228-8232 (March, 2009). PubMed
Han, Q., Robinson H., Cai, T., Tagle, D. A., and Li, J.
Biochemical and structural properties of mouse kynurenine aminotransferase III.
Molecular and Cellular Biology, 29(3):784-793 (February, 2009). PubMed
Han, Q., Robinson H., Cai, T., Tagle, D. A., and Li, J.
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.
Journal of Medicinal Chemistry, 52(9):2786-2793 (May, 2009). PubMed
Scott, F. L., Stec, B., Pop, C., Dobaczewska, M. K., Lee, J. J., Monosov, E., Robinson H., Salvesen, G. S., Schwarzenbacher, R., and Riedl, S. J.
The Fas-FADD death domain complex structure unravels signaling by receptor clustering.
Nature, 457(7232):1019-1022 (February, 2009). PubMed
Woo, J.-S., Lim, J.-H., Shin, H.-C., Suh, M.-K., Ku, B., Lee-K.-H., Joo, K., Robinson H., Lee, J., Park, S.-Y., Ha, N.-C., and Oh, B.-H.
Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions.
Cell, 136(1):85-96 (January, 2009). PubMed
Zhang, Y., Cao, R., Yin, F., Hudock, M. P., Guo, R.-T., Krysiak, K., Mukherjee, S., Gao, Y.-G., Robinson H., Song, Y., No, J. H., Bergan, K., Leon, A., Cas, L., Goddard, A., Chang, T.-K., Lin, F.-Y., Van Beek, E., Papapoulos, S., Wang, A. H.-J., Kubo, T., Ochi, M., Mukkamala, D., and Oldfield, E.
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl disphosphate synthase inhibitors: An x-ray and NMR investigation.
Journal of the American Chemical Society, 131(14):5153-5162 (April, 2009). PubMed
Buchko G.W., Litvinova O., Robinson H., Yakunin A.F. and Kennedy M.A.
Functional and structural characterization of DR_0079 from Deinococcus radiodurans, a novel nudix hydrolase with a preference for cytosine (deoxy)ribonucleoside 5’Di- and triphosphates.
Biochemistry, 47(5):6571-6582 (2008). PubMed
Buchko G.W., Robinson H., Pakrasi H.B. and Kennedy M.A.
Insights into the structural variation between pentapeptide repeat proteins—Crystal structure of Rfr23 from Cyanothece 51142.
Journal of Structural Biology, 162(1):184-192 (2008). PubMed
Chen G., Wang H., Robinson H., Cai J., Wan Y. and Ke H.
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies.
Biochemical Pharmacology, 75(9):1717-1728 (2008). PubMed
Greenhagen B.T., Shi K., Robinson H., Gamage S., Bera A.K., Ladner J.E. and Parsons J.F.
Crystal structures of the pyocyanin biosynthetic protein PhzS.
Biochemistry, 47(19):5281-5289 (2008). PubMed
Han Q., Cai T., Tagle D.A., Robinson H. and Li J.
Substrate specificity and structural insight of human aminoadipate aminotransferase/kynurenine aminotransferase II.
Bioscience Reports, 28(4):205-215 (2008). PubMed
Han Q.,Gao Y.G., Robinson H. and Li J.
Structural insight into the mechanism of Substrate specificity of Aedes Kynurenine Aminotransferase II.
Biochemistry, 47(6):1622-1630 (2008). PubMed
Han Q., Robinson H. and Li J.
Crystal structure of human kynurenine aminotransferase II.
J Biol Chem., 283(6):3567-3573 (2008). PubMed
Johnson S.J., Close D., Robinson H., Vallet-Gely I., Dove S.L. and Hill C.P.
Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa.
Journal of Molecular Biology, 377(5):1460-1473 (2008). PubMed
Kim S.K., Reddy S.K., Nelson B.C., Robinson H., Reddy P.T. and Ladner J.E.
A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H37Rν and the secreted chorismate mutase (y2828) from Yersinia pestis.
FEBS Journal, 275(19):4824-4835 (2008). PubMed
Soares A.S., Schneider D.K., Skinner J.M., Cowan M., Buono R., Robinson H.H., Heroux A., Carlucci-Dayton M., Saxena A., and Sweet R.M.
Remote access to the PXRR macromolecular crystallography facilities at the NSLS.
Synchrotron Radiation News, 21(5):17-23 (September, 2008).
Wang H., Yan Z., Yang S., Cai J., Robinson H., Ke H.
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.
Biochemistry, 47(48):12760-12768 (December, 2008). PubMed
Wang H., Ye M., Robinson H., Francis S.H. and Ke H.
Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Molecular Pharmacology, 73(1):104-110 (2008). PubMed
Wingard J.N., Ladner J., Vanarotti M., Fisher A., Robinson H., Buchanan K.T., Engman D.M. and Ames J.B.
Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi.
Journal of Biological Chemistry, 283(34):23388-23396 (2008). PubMed
Fisher R.D., Chung H.Y., Zhai Q., Robinson H., Sundquist W.I. and Hill C.P.
Structural and Biochemical Studies of ALIX/AIP1 and Its Role inRetrovirus Budding.
Cell, 128:841-52 (2007). PubMed
Keiski C.L., Yip P., Robinson H., Burrows L.L. Howell P.L.
Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas fluorescens AlgK.
Acta Cryst., F63:415-418 (2007). PubMed
Kelly B.N., Kyere S., Kinde I., Tang C., Howard B.R., Robinson H., Sundquist W.I., Summers M.F., Hill C.P.
Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein.
J. Mol Biol., 373:355-366 (2007). PubMed
Mans J., Natarajan K., Balbo A., Schuck P., Eikel D., Hess S., Robinson H., Simic H., Jonjic S., Tiemessen C.T and Margulies D.H.
Cellular expression and crystal structure of the murine cytomegalovirus MHC-Iv glycoprotein, m153.
J Biol Chem., 282:35247-35258 (2007). PubMed
Moore B.A., Robinson H.H. and Xu Z.
The Crystal Structure of Mouse Exo70 Reveals Unique Features of the Mammalian Exocyst.
J. Mol. Biol., 371(2):410-421 (2007).
Medline Abstract. PubMed
Oruganti S., Zhang Y., Li H., Robinson H., Terns M.P., Terns R.M., Yang W., Li H.
Alternative Conformations of the Archaeal Nop56/58-Fibrillarin Complex Imply Flexibility in Box C/D RNPs.
J. Mol. Biol., 371:1141-1150 (2007). PubMed
Parson J.F., Greenhagen B.T., Shi K., Calabrese K., Robinson H. and Ladner J.E.
Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa.
Biochemistry, 46:1821-1828 (2007). PubMed
Pfister T.D., Mirareli A.Y., Gengenbach A.J., Zhaoi X., Danstrom C., Conaster N., Gao Y.G., Robinson H., Zukoski C.F., Wang A.H. and Lu Y.
Kinetic and crystallographic studies of a redesigned manganese-binding site in cytochrome c peroxidase.
J. Biol. Inorg. Chem., 1:126-137 (2007). PubMed
Wang H., Liu Y., Hou J., Zheng M., Robinson H. and Ke H.
Structural insight into substrate specificity of phosphodiesterase 10.
Proc Natl Acad Sci U S A., 104(14):5782-5787 (2007). PubMed
Wang H., Peng M., Chen Y., Geng J., Robinson H., Houslay M.D., Cai J. and Ke H.
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem J., 408:193-201 (2007). PubMed
Wang H., Robinson H. and Ke H.
The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10.
J. Mol. Biol., 371:302-307 (2007). PubMed
Wang H., Ye M., Robinson H., Francis S.H. and Ke H.
Conformational variations of both PDE5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol Pharmacol., 73(1):104-110 (2007). PubMed
Zhang Y., Cao R., Leon A., Guo R.T., Krysiak K., Yin F., Hudock M.P., Mukherjee S., Gao Y.G., Robinson H., Song Y., No J.H., Hong W., Morita C., Wang A.H.-J. and Oldfield E.
Bisphosphonates: Teaching Old Drugs with New Tricks.
Alam S.L., Langelier C., Whitby F.G., Koirala S., Robinson H., Hill C.P. and Sundquist W.I.
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
Nat Struct Mol Biol., 11:1029-1030 (2006). PubMed
Buchko G.W., Ni S., Robinson H., Welsh E.A., Pakrasi H.B. and Kennedy M.A.
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142.
Protein Sci., 11:2579-2595 (2006). PubMed
Buchko G.W., Ni S., Robinson H., Welsh E.A., Pakrasi H.B. and Kennedy M.A.
Cloning, expression, crystallization and preliminary crystallographic analysis of a pentapeptide-repeat protein (Rfr23) from the bacterium Cyanothece 51142.
Acta Cryst., F62:1251-1254 (2006). PubMed
Gallager D.T., Smith N.N., KIM S.K., Heroux A., Robinson H. and Reddy P.T.
Structure of the Class IV Adenylyl Cyclase Reveals a Novel Fold.
J Mol Biol., 362(1):114-122 (2006). PubMed
Han Q., Robinson H., Gao Y.G., Vogelaar N., Wilson S.R., Rizzi M. and Li J.
Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.
J Biol Chem., 281(48):37175-37182 (2006). PubMed
Huai Q., Sun Y., Wang H., Macdonald D., Aspiotis R., Robinson H., Huang Z. and Ke H.
Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase.
J Med Chem., 49:1867-1873 (2006). PubMed
Kelly N.B., Howard B.R., Wang H., Robinson H., Sundquist W.I. and Hill C.P.
Implications for Viral Capsid Assembly from Crystal Structures of HIV-1 Gag(1)(-)(278) and CA(N)(133)(-)(278)(,).
Biochemistry, 45:11257-11266 (2006). PubMed
Natarajan K., Hicks A., Mans J., Robinson H., Guan R., Mariuzza R.A. and Margulies D.H.
Crystal structure of the murine cytomegalovirus MHC-I homolog m144.
J Mol Biol., 358(1):157-171 (2006). PubMed
Ni S., Forouhar F., Bussiere D.E., Robinson H. and Kennedy M.A.
Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae.
Proteins., 63:733-741 (2006). PubMed
Robinson H., Soares A.S., Becker M., Sweet R. and Heroux A.
Mail-in crystallography program at Brookhaven National Laboratory's National Synchrotron Light Source.
Acta Cryst., D62(11):1336-1339 (2006). PubMed Full Text
Sanghani P.C., Davis W.I., Zhai L. and Robinson H.
Structure-function relationships in human glutathione-dependent formaldehyde dehydrogenase. Role of Glu-67 and Arg-368 in the catalytic mechanism.
Biochemistry, 18:4819-4830 (2006). PubMed
Shi W., Robinson H., Sullivan M., Abel D., Toomey J., Berman L.E., Lynch D., Rosenbaum G., Rakowsky G., Rock L., Nolan B., Shea-McCarthy G., Schneider D., Johnson E., Sweet R.M. and Chance M.R.
Beamline X29: a novel undulator source for X-ray crystallography.
J Synch Rad., 13:365-372 (2006). PubMed Full Text
Skinner J.M., Cowan M., Buono R., Nolan W., Bosshard H., Robinson H.H., Heroux A., Soares A.S., Schneider D.K. and Sweet R.M.
Integrated software for macromolecular crystallography synchrotron beamlines II: revision, robots and a database
Acta Cryst., D62(11):1340-1347 (2006). PubMed Full Text
Wang H., Liu Y., Huai Q., Cai J., Zoraghi R., Francis S.H., Corbin J.D., Robinson H., Xin Z., Lin G. and Ke H.
Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.
J Biol Chem., 281(30):21469-21479 (2006). PubMed
Bitto E., Bingman C.A., Robinson H., Allard S.T.M., Wesenberg G.E., and Phillips Jr G.N.
The structure at 2.5 Å resolution of human basophilic leukemia-expressed protein BLES03.
Acta Cryst Section, F61(9):812-817 (2005). PubMed

Brown J.H., Zhou Z., Reshetnikova L., Robinson H., Yammani R.D., Tobacman L.S. and Cohen C.
Structure of the mid-region of tropomyosin: Bending and binding sites for actin.
Proc Natl Acad Sci USA., 102(52):18878-18883 (2005). PubMed Full Text
PDB file 2B9C Jmol viewer

Forster A., Masters E.I., Whitby F.G., Robinson H. and Hill C.P.
The 1.9 Å structure of proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Mol Cell, 18:589-599 (2005). PubMed
PDB files 1YAR, 1Z7Q Jmol viewer

Han Q., Gao Y.G., Robinson H., Ding H., Wilson S. and Li J.
Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272(9):2198-2206 (2005). PubMed
PDB files 1YIY, 1YIZ Jmol viewer
Li F., Robinson H., and Yeung E.S.
Automated high-throughput nanoliter-scale protein crystallization screening.
Anal Bioanal Chem, 383(7-8):1034-1041 (2005). PubMed
Robinson H.H., Shi W., Sullivan M., Nolan W., Schneider D.K., Berman L., Lynch D., Rock L., Rosenbaum G., Johnson E., Chance M.R. and Sweet R.M.
An undulator beamline for protein crystallography at the NSLS: Commissioning and operation of X29.
Synch Rad News, 18(5):27-31 (2005). Full Text

Safo M.K., Zhao Q., Ko T.-P., Musayev F.N., Robinson H., Scarsdale N., Wang A.H.-J., and Archer G.L.
Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: Insights into transcriptional regulation of the bla and mec operons.
J Bacteriol., 187(5):1833-1844 (2005). PubMed Full Text
PDB files 1SD4, 1ZSD Jmol viewer

Wang H., Liu Y., Chen Y., Robinson H. and Ke H.
Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
J Biol Chem., 280(35):30949-30955 (2005). PubMed Full Text
PDB file 1ZKL Jmol viewer

Gallagher D.T., Monbouquette H.G., Schroder I., Robinson H., Holden M.J. and Smith N.N.
Structure of alanine dehydrogenase from Archaeoglobus: Active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
J Mol Biol., 342(1):119-130 (2004). PubMed
PDB file 1OMO Jmol viewer

Hou M.H., Robinson H., Gao Y.G. and Wang A.H.J.
Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion.
Nucl Acids Res., 32(7):2214-2222 (2004). PubMed Full Text
PDB file 1VAQ Jmol viewer

Huai Q., Wang H., Zhang W., Colman R.W., Robinson H. and Ke H.
Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.
Proc Natl Acad Sci USA, 101(26):9624-9629 (2004). PubMed Full Text
PDB file 1TBM Jmol viewer

Karthikeyan S., Zhou Q., Zhao Z., Kao C.L., Tao Z., Robinson H., Liu H.W. and Zhang H.
Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: Insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.
Biochemistry, 43(42):13328-13339 (2004). PubMed
PDB files 1TZ2, 1TZK, 1TZM, 1TYZ, 1TZJ Jmol viewer
Mao J., Gao Y.G., Odeh S., Robinson H., Montalvetti A., Docampo R. and Oldfield E.
Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei.
Acta Cryst, D60(10):1863-1866 (2004). PubMed

Ni S., Robinson H., Marsing G.C., Bussiere D.E. and Kennedy M.A.
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 Å: Identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.
Acta Cryst Section, D60:1949-1957 (2004). PubMed
PDB file 1T0A Jmol viewer

Phillips J.D., Whitby F.G., Warby C.A., Labbe P., Yang C., Pflugrath J.W., Ferrara J.D., Robinson H., Kushner J.P. and Hill C.P.
Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.
J Biol Chem., 279(37):38960-38968 (2004). PubMed Full Text
PDB files 1TK1, 1TKB, 1TKL Jmol viewer

Saxena S., Yuan P., Dhar S.K., Senga T., Takeda D., Robinson H., Kornbluth S., Swaminathan K. and Dutta A.
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Mol Cell, 15(2):245-258 (2004). PubMed
PDB file 1UII Jmol viewer

Schwarzenbacher R., Stenner-Liewen F., Liewen H., Robinson H., Yuan H., Bossy-Wetzel E., Reed J.C. and Liddington R.C.
Structure of the Chlamydia protein CADD reveals a redox-enzyme that modulates host cell apoptosis.
J Biol Chem., 279(28):29320-29324 (2004). PubMed Full Text
PDB file 1RCW Jmol viewer

Smith N., Mayhew M., Holden M.J., Kelly H., Robinson H., Héroux A., Vilker V.L. and Gallagher D.T.
Structure of C73G putidaredoxin from Pseudomonas putida.
Acta Cryst, D60(5):816-822 (2004). PubMed
PDB file 1R7S Jmol viewer

Woo E.J., Kim Y.G., Kim M.S., Han W.D., Shin S., Robinson H., Park S.-Y. and Oh B.-H.
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway.
Mol Cell, 14(4):531-539 (2004). PubMed
PDB file 1V0D Jmol viewer

Fisher R.D., Wang B., Alam S.L., Higginson D., Rich R., Myszka D., Robinson H., Sundquist W.I. and Hill C.P.
Structure and ubiquitin binding of the ubiquitin interacting motif.
J. Biol. Chem., 278(31):28976-84 (2003). PubMed Full Text
PDB file 1O06

Huai Q., Sun Y., Wang H., Chin L.S., Li L., Robinson H. and Ke H.
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease.
FEBS Lett., 549(1-3):171-175 (2003). PubMed
PDB files 1PS4, 1Q2U

Ko T.P., Robinson H., Gao Y.G., Chen C.H., DeVries A.L. and Wang A.H.J.
The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural micorheterogeneity of protein and solvation.
Biophys. J., 84(2):1228-1237 (2003). PubMed
PDB file 1UCS

Paaventhan P., Joseph J.S., Seow S.V., Vaday S., Robinson H., Chua K.Y. and Kolatkar P.R.
A 1.7A structure of Fve, a member of the new fungal immunomondulatory protein family.
J Mol Biol., 332(2):461-470 (2003). PubMed
PDB file 1OSY
Sanghani P.C., Robinson H., Bennett-Lovsey R., Hurley T.D. and Bosron W.F.
Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).
Chem. Biol. Interact., 143-144:195-200 (2003). PubMed
Smith N., Mayhew M., Robinson H., Héroux A., Charlton D., Holden M.J. and Gallagher D.T.
Crystallization and phasing of alanine dehydrogenase from Archaeoglobus fulgidus.
Acta Cryst., D59(12):2328-2331 (2003). PubMed

Singh S.K., Kurnasov O.V., Chen B., Robinson H., Grishin N.V., Osterman A.L. and Zhang H.
Crystal structure of Haemophilis influenzae NadR protein. A bifunctional enzmye endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities.
J Biol Chem., 277(36):33291-33299 (2002). PubMed Full Text
PDB file 1LW7

Sanghani P.C., Robinson H., Bosron W.F. and Hurley T.D.
Human glutathione-dependent formaldehyde dehydorgenase. Structural basis of the random kinetic mechanism.
Biochemistry, 41(35):10778-10786 (2002). PubMed
PDB files 1M6H, 1M6W, 1MAO

Hou M.-H., Robinson H., Gao J.G. and Wang A.H.J.
Crystal structure of Actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases.
Nucleic Acids Res., 30(22):4910-4917 (2002). PubMed
PDB file 1MNV

Ko T.P., Chen Y.K., Robinson H., Tsai P.C., Gao Y.G., Chen A.P., Wang A.H. and Liang P.H.
Mechanism of product chain length determination and the role of flexible loop in Escherichia coli undecaprenyl pyrophosphate synthase
J Biol Chem., 276(50):47474-82 (2001). PubMed Full Text
PDB file 1JP3

Robinson H., Gao Y.G., Yang X.L., Sanishvili R., Joachimiak A. and Wang A.H.
Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG.
Biochemistry, 40(19):5587-5592 (2001). PubMed
PDB file 1I3W

Robinson H., Gao Y.G., Sanishvili R., Joachimiak A., and Wang A.H.J.
Hexaydrated magnesium ions bind to the deep major groove and at the outer mouth of A-form nucleic acid duplexes.
Nucleic Acids Res., 28:1760-1766 (2000). PubMed
PDB files 1DNZ, 1DNO, 1DNT, 1DNX

Su S., Gao Y.G., Robinson H., Liaw Y.C., Edmondson S.P., Shriver J.W. and Wang A.H.
Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base pairs.
J Mol Biol., 303(3):395-404 (2000). PubMed
PDB files 1C8C, 1CA5, 1CA6

Yang X.L., Robinson H., Gao Y.G., and Wang A.H.J.
Binding of a macrocyclic bisacridine and amentantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39(36):10950-10957 (2000). PubMed
PDB files 1FDG, 1FD5

Robinson H., Ang M.C., Gao Y.G., Hay M.T., Lu Y. and Wang A.H.J.
Structural basis of electron transfer modulation in the purple Cu-A center.
Biochemistry, 38:5677-5683 (1999). PubMed
PDB file 1CC3

Robinson H., Gao Y.G., McCrary B.S., Edmondson S.P., Shriver J.W. and Wang A.H.J.
The hyperthermophile chromosomal protein Sac7d sharply kinks DNA.
Nature, 392:202-205 (1998). PubMed
PDB files 1AZQ, 1AZP, 1CA5, 1CA6

Robinson H., Priebe W., Chaires J.B., and Wang A.H.J.
Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy.
Biochemistry, 36:8663-8670 (1997). PubMed
PDB files 1AL9, 1AMD

Last Modified: June 16, 2009
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