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Cover Illustration: A biochemical hallmark of programmed cell death is the degradation of chromosomal DNA into nucleosomal units. Caspase-activated DNase, also known as DNA fragmentation Factor 40, is responsible for this process. In this issue, Woo et al. report the crystal structure of the enzyme (pp. 531-539), which reveals a deep active site crevice that appears ideal for distinguishing internucleosomal DNA from nucleosomal DNA.

Woo, E.-J., Kim, Y.-G., Kim, M.-S., Han, W.-D., Shin, S., Robinson, H., Park, S.-Y., and Oh, B.-H.
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway.
Molecular Cell 14(4): 531-539 (May, 2004).
Medline Abstract,   PDB file 1V0D

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DOE, Office of Science One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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