General Information

Top of Page

Jacob M. Hooker

Research Interests

  • Epigenetics; neurotransmitter Systems; organic synthesis; radiotracer design and synthesis with positron-emitting isotopes; radiochemistry methodology

Recent Awards

  • Presidential Early Career Award for Scientists and Engineers (PECASE)

Selected Publications

  • Neelamegam R., Ricq E.L., Malvaez M., Patnaik D., Norton S., Carlin S.M., Hill I.T., Wood M.A., Haggarty S.J., and Hooker J.M.
    Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem. Neurosci., 3(2):120-128 (Feb 2012).  PubMed
  • Ran C., Zhang Z., Hooker J., and Moore A.
    In Vivo Photoactivation Without "Light": Use of Cherenkov Radiation to Overcome the Penetration Limit of Light.
    Mol. Imaging Biol., 14(2):156-162 (Apr 2012).  PubMed
  • Behrens C.R., Hooker J.M., Obermeyer A.C., Romanini D.W., Katz E.M., and Francis M.B.
    Rapid Chemoselective Bioconjugation through Oxidative Coupling of Anilines and Aminophenols.
    Journal of the American Chemical Society, 133(41):16398-16401 (Oct 2011).  PubMed
  • Lee E., Kamlet A.S., Powers D.C., Neumann C.N., Boursalian G.B., Furuya T., Choi D.C., Hooker J.M., and Ritter T.
    A Fluoride-derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging.
    Science, 334(6056):639-642 (Nov 2011).  PubMed
  • Reid A.E., Kim S.W., Seiner B., Fowler F.W., Hooker J., Ferrieri R., Babst B. and Fowler J.S.
    Radiosynthesis of C-11 labeled auxin (3-indolyl[1-11C]acetic acid) and its derivatives from gramine.
    J. of Labelled Compounds and Radiopharm., (wileyonlinelibrary.com) DOI: 10.1002/jlcr.1894 (Mar 2011).  pdf
  • Riss P.J., Hooker J.M., Shea C., Xu Y., Carter P., Warner D., Ferrari V., Kim S.W., Aigbirhio F.I., Fowler J.S., and Roesch F.
    Characterisation of [11C]PR04.MZ in papio anubis baboon: A selective high-affinity radioligand for quantitative imaging of the dopamine transporter.
    Bioorg. Med. Chem. Lett., 22(1):679-682. (Jan 2012).  PubMed
  • Biegon A., Won Kim S., Logan J., Hooker J.M., Muench L., and Fowler J.S.
    Nicotine Blocks Brain Estrogen Synthase (Aromatase): In Vivo Positron Emission Tomography Studies in Female Baboons.
    Biol. Psychiatry, 67(8):774-777 (2010).  PubMed
  • Hooker J.M.
    Modular strategies for PET imaging agents.
    Curr. Opin. Chem. Biol., 14(1):105-111. PMCID: 2819636 (2010).  PubMed
  • Hooker J.M., Kim S.W., Reibel A.T., Alexoff D., Xu Y., and Shea C.
    Evaluation of [11C]metergoline as a PET radiotracer for 5HTR in nonhuman primates.
    Bioorg Med Chem., 18(22):7739-7745. (Nov 2010).  PubMed
  • Liu L., Xu Y., Shea C., Fowler J.S., Hooker J.M., and Tonge P.J.
    Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons.
    J. Med. Chem., 53(7):2882-2891 (Apr 2010).  PubMed
  • Schonberger M., Leggett C., Kim S.W., and Hooker J.M.
    Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography.
    Bioorg Med Chem Lett., 20(10):3103-3106 (May 2010).  PubMed
  • Fowler J.S., Volkow N.D., Logan J., Alexoff D., Telang F., Wang G.J., Hooker J.M., Wong C., Hubbard B., Carter P., Warner D., King P., Shea C., Xu Y., Muench L., Pujari N., and Apelskog K.
    Modafinil Blocks Dopamine Transporters and Decreases Dopamine D2 Receptor Availability in Human Brain: Evidence of Dopaminergic Effects.
    Journal of the American Medical Association, 301(11):1148-1154 (2009).
    Highlighted in (among others) the NY Times and The New Yorker.
  • Hooker J.M., Kim S.W., Alexoff D., Xu Y., Shea C., Reid A., et al.
    Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 using Positron Emission Tomography.
    ACS Chemical Neuroscience, 1(1):65-73 (2009).
  • Hooker J.M., Munro T.A., Beguin C., Alexoff D., Shea C., Xu Y., et al.
    Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence.
    Neuropharmacology, 57(4):386-391. PMCID: 2745083 (2009).  PubMed
  • Hooker J.M., Patel V., Kothari S., and Schiffer W.K.
    Metabolic Changes in the Rodent Brain after Acute Administration of Salvinorin A.
    Molecular Imaging and Biology, 11(3):137-143 (May-June 2009).  PubMed
  • Hooker J.M., Reibel A.T., Hill S.M., Schueller M.J., and Fowler J.S.
    One-pot, Direct Incorporation of [11C]-CO2 into Carbamates.
    Angewandte Chemie International Edition, 48(19):3482-3485 (2009).  PubMed
  • Kim S.W., Biegon A., Katsamanis Z.E., Ehrlich C., Hooker J.M., Shea C., Muench L., Xu Y., King P., Carter P., Alexoff D.L., and Fowler J.S.
    Reinvestigation of the Synthesis and Evaluation of [N-methyl-11C]Vorozole, a Radiotracer Targeting Cytochrome P450 Aromatase.
    Nuclear Medicine and Biology, 36(3):323-334 (Apr 2009).  PubMed
  • Reid A.E., Hooker J.M., Shumay E.M., Kim S.W., Logan J., Shea C., Xu Y., Volkov N.D., and Fowler J.S.
    Assessment of [18F]FAHA for PET imaging of HDAC in the baboon brain.
    Nuclear Medicine and Biology, 39(3):247-258 (Apr 2009).  PubMed
  • Riss P.J., Hooker J.M., Alexoff D., Kim S.W., Fowler J.S., and Rösch F.
    [11C]PR04MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient 11C-O-methylation and initial small animal PET studies.
    Bioorg. Med. Chem. Lett., 19(15):4343-4345 (Aug 2009).  PubMed
  • Schiffer W.K., Liebling C.N.B., Reiszel C., Hooker J.M., Brodie J.D., and Dewey S.L.
    Cue-induced dopamine release predicts preference: PET studies in freely moving rodents.
    The Journal of Neuroscience, 29(19):6176-6185 (2009).  PubMed
  • Datta A., Hooker J.M., Botta M., Francis M.B., and Raymond K.
    Relaxometric Properties of Gadolinium Hydroxypyridonate – Viral Capsid Conjugates: Nano-sized Contrast Media with High Relaxivities at High Field.
    Journal of the American Chemical Society, 130(8):2546 -2552 (2008).
  • Hooker J.M., O’Neil J.P., Romanini D.W., Taylor S.E., and Francis M.B.
    Genome-free Viral Capsids as Carriers for Positron Emission Tomography Radiolabels.
    Molecular Imaging and Biology, 10(4):182-191 (Jul-Aug 2008).  PubMed
  • Hooker J.M., Schönberger M., Schieferstein H., and Fowler J.S.
    A simple, rapid method for the preparation of [11C]-formaldehyde.
    Angewandte Chemie International Edition, 47(32):5989-5992 (2008).   PubMed Highlighted in: C&E News Concentrate, CancerResearchJournal.com, Society of Nuclear Medicine Editor’s Choice, Nature Chemistry
  • Hooker J.M., Xu Y., Carter P., Schiffer W., Shea C., and Fowler J.S.
    Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset, short duration of effects in humans.
    NeuroImage, 41(3):1044-1050 (Jul 2008).  PubMed
    Highlighted in: PBS News Hour & many online news articles.
  • Hooker J.M., Datta A., Botta M., Raymond K., and Francis M.B.
    Magnetic Resonance Contrast Agents from Viral Capsid Shells: A Comparison of Exterior and Interior Cargo Strategies.
    Nano Letters, 7(8):2207-2210 (2007).  PubMed
  • Hooker J.M., Esser-Kahn A.P., and Francis M.B.
    Modification of Aniline Containing Proteins Using an Oxidative Coupling Strategy.
    Journal of the American Chemical Society, 128:15558–15559 (2006).  PubMed
  • Hooker J.M., Kovacs E.W., and Francis M.B.
    Interior surface modification of bacteriophage MS2.
    Journal of the American Chemical Society, 126:3718-3719 (2004).   PubMed Highlighted in: C&E News, Faculty of 1000 Biology