Deborah Keszenman

Research Interests

• Clustered DNA damage induced by ionizing radiation of different LET and energies.
• Lethal and mutagenic effects induced by oxidative stress in eukaryotic cells.
• Characterization and analysis of the repair pathways involved in the processing of DNA damage induced by oxidative stress in eukaryotic cells.
• Interrelation between stress responses in eukaryotic cells.

Recent News

Selected Publications

• Keszenman D.J., B.M. Sutherland
  Yields of Clustered DNA Damage Induced by Charged-Particle Radiations of Similar Kinetic Energy per Nucleon: LET Dependence in Different DNA Microenvironments.
  Radiation Research, 174:238–250 (2010).
• Bracesco N., Candreva E.C., Keszenman D., Sanchez A.G., Soria S., Dell M., Siede W. and Nunes E.
  Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genes in the repair of double-strand breaks in cycling cells.
  Radiat. Environ. Biophys., 46(4):401-407 (2007).  PubMed
• Keszenman D.J., Candreva E.C., Sanchez A.G. and Nunes E.
  RAD6 gene is involved in heat shock induction of bleomycin tolerance in Saccharomyces cerevisiae.
  Environ. Mol. Mutagen., 45(1):36-43 (2005).  PubMed
• Candreva E.C., Keszenman D.J. and Nunes E.
  RAD6 gene is involved in bleomycin tolerance induced by heat shock in Saccharomyces cerevisiae.
  Environ. Mol. Mutagen., 37:24 (2001).
• Candreva E.C., Keszenman D.J. and Nunes E.
  Yeast stress responses in the stationary phase of growth.
  Biocell, 25:52 (2001).
• Keszenman D.J., Candreva E.C. and Nunes E.
  Role of RAD6/UBC2 gene of Saccharomyces cerevisiae in cell cycle transitions.
  Biocell, 25:51 (2001). 
• Keszenman D.J., Candreva E.C. and Nunes E.
  Cellular and molecular effects of bleomycin are modulated by heat shock in Saccharomyces cerevisiae.
  Mutation Res., 459(1):29-41 (2000). PubMed
• Keszenman D.J., Candreva E.C. and Nunes E.
  Differential DNA repair induced by heat shock and bleomycin in yeast cells.
  J. Biosciences, 24:105 (1999).
• Keszenman D.J., Candreva E.C. and Nunes E.
  Cycloheximide interacts with bleomycin induced oxidative stress.
  Environ. Mol. Mutagenesis, 27:35 (1996).
• Keszenman D.J., Santos J.F., Boeira J.M., Saffi J. and Henriques J.A.P.
  Heat shock changes the response of pso3 mutant of Saccharomyces cerevisiae to 8-methoxypsoralen photoaddition.
  Curr. Genet., 26(2):100-104 (1994). PubMed
• Santos J.F., Keszenman D.J., Boeira J., Saffi J. and Henriques J.A.P.
  Choque térmico afeta a resposta dos mutantes pso de Saccharomyces cerevisiae a fotoadicao de 8-MOP.
  Rev. Brasilera de Genética, 16:56 (1993).
• Nunes E., Candreva E.C., Keszenman D.J. and Salvo. V.A.
  The mutagenic effect of elevated temperatures in yeast is blocked by a previous heat shock.
  Mutation Res., 289(2):165-170 (1993). PubMed
• Candreva E.C., Keszenman D.J., Barrios E., Gelós U. and Nunes E.
  Mutagenicity induced by hyperthermia, hot mate infusion, and hot caffeine in Saccharomyces cerevisiae.
  Cancer Res., 53(23):5750-5753 (1993). PubMed
• Keszenman D.J., Salvo V.A., Nunes E.
  Effects of Bleomycin on growth kinetics and survival of Saccharomyces cerevisiae: a model of repair pathways.
  J. Bacteriology, 174:3125-3132 (1992).