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Dardo Tomasi

Research Interests

    Along the years my work has shifted from nuclear and astroparticle physics to MRI gradient coil design, functional MRI and PET imaging. I developed the Phase Reference Method, an MRI technique to map the magnetic fields with high spatial and temporal resolutions that allows to optimize the design of MRI magnets as well as radio frequency and gradient coils which is also valuable for MRI quality control purposes, and the Fast Simultaneous Annealing Method, a novel gradient coil design technique that allows the development of ultra-short gradient coils for faster MRI protocols. I studied the resonant modes of vibration and was able to minimize significantly the sound pressure levels emitted by of our 4T Varian/Siemens MRI scanner, reducing subject’s discomfort during fMRI. More recently I developed ultra-fast graph theory methods to compute short- and long-range functional connectivity maps from "resting-state" echo-planar imaging time series that when used in large public image databases revealed pronounced gender and aging effects on the brain's functional architecture. My work has also focused on cognition, addiction, obesity, ADHD and HIV-infection.

Recent News

Selected Publications

  • Dilmanian F.A., Rusek A., Fois G.R., Olschowka J., Desnoyers N.R., Park J.Y., Dioszegi I., Dane B., Wang R., Tomasi D., Lee H., Hurley S.D., Coyle P.K., Meek A.G., and O'Banion M.K.
    Interleaved Carbon Minibeams: An Experimental Radiosurgery Method With Clinical Potential.
    Int. J. Radiat. Oncol. Biol. Phys., [Epub ahead of print] (2012 Feb).  PubMed
  • Honorio J., Tomasi D., Goldstein R., Leung H., and Samaras D.
    Can a Single Brain Region Predict a Disorder?
    IEEE Trans Med Imaging. [Epub ahead of print] (2012 Jun 26).  PubMed
  • Konova A.B., Moeller S.J., Tomasi D., Parvaz M.A., Alia-Klein N., Volkow N.D., and Goldstein R.Z.
    Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction.
    Eur J Neurosci., 36(7):2979-88. doi: 10.1111/j.1460-9568.2012.08211.x. Epub 2012 Jul 9. (2012 Oct).  PubMed
  • Moeller S.J., Tomasi D., Honorio J., Volkow N.D., and Goldstein R.Z.
    Dopaminergic involvement during mental fatigue in health and cocaine addiction.
    Transl Psychiatry, 2:e176. doi: 10.1038/tp.2012.110. (2012 Oct 23).  PubMed
  • Moeller S.J., Tomasi D., Woicik P.A., Maloney T., Alia-Klein N., Honorio J., Telang F., Wang G.-J., Wang R., Sinha R., Carise D., Astone-Twerell J., Bolger J., Volkow N.D., and Goldstein R.Z.
    Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice.
    Addict Biol., 17(6):1013-25. doi: 10.1111/j.1369-1600.2012.00440.x. Epub 2012 Mar 28. (2012 Nov).  PubMed
  • Tomasi D., and Volkow N.D.
    Language network: segregation, laterality and connectivity.
    Mol Psychiatry, 17(8):759. doi: 10.1038/mp.2012.99. No abstract available. (2012 Jul).  PubMed
  • Tomasi D., and Volkow N.D.
    Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder.
    Biol. Psychiatry, 71(5):443-50. Epub 2011 Dec 6. (2012 Mar).  PubMed
  • Tomasi D., and Volkow N.D.
    Resting functional connectivity of language networks: characterization and reproducibility.
    Mol. Psychiatry, doi: 10.1038/mp.2011.177. [Epub ahead of print] (2012 Jan).  PubMed
  • Volkow N.D., Kim S.W., Wang G.J., Alexoff D., Logan J., Muench L., Shea C., Telang F., Fowler J.S., Wong C., Benveniste H., and Tomasi D.
    Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain.
    Neuroimage,64C:277-283. doi: 10.1016/j.neuroimage.2012.08.057. [Epub ahead of print] (2012 Aug 28).  PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Logan J., Benveniste H., Kim R., Thanos P.K., and Ferré S.
    Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.
    J Neurosci., 32(19):6711-6717 (2012 May 9).  PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., and Tomasi D.
    Addiction circuitry in the human brain.
    Annu. Rev. Pharmacol. Toxicol., 52:321-336. Epub 2011 Sep 27. (2012 Feb).  PubMed
  • Volkow N.D., Wang G.J., Tomasi D., and Baler R.D.
    Obesity and addiction: neurobiological overlaps.
    Obes Rev., doi: 10.1111/j.1467-789X.2012.01031.x. [Epub ahead of print] (2012 Sep 27).   PubMed
  • Volkow N.D., Wang G.J., Tomasi D., Kollins S.H., Wigal T.L., Newcorn J.H., Telang F.W., Fowler J.S., Logan J., Wong C.T., and Swanson J.M.
    Methylphenidate-Elicited Dopamine Increases in Ventral Striatum Are Associated with Long-Term Symptom Improvement in Adults with Attention Deficit Hyperactivity Disorder.
    J. Neurosci., 32(3):841-849 (2012 Jan).   PubMed
  • Alia-Klein N., Parvaz M.A., Woicik P.A., Konova A.B., Maloney T., Shumay E., Wang R., Telang F., Wang G.J., Fowler J.S., Tomasi D., Volkow N.D., and Goldstein R.Z.
    Gene x Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction.
    Arch Gen Psychiatry, 68:283-294 (2011).   PubMed
  • Parvaz M.A., Konova A.B., Tomasi D., Volkow N.D., and Goldstein RZ.
    Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward.
    J. Cogn. Neurosci., [Epub ahead of print] (2011).   PubMed
  • Solis S.E., Wang R., Tomasi D., and Rodriguez A.O.
    A multi-slot surface coil for MRI of dual-rat imaging at 4 T.
    Phys. Med. Biol., 56(12):3551-3561. Epub 2011 May 23. (2011).   PubMed
  • Tomasi D. and Volkow N.D.
    Association between functional connectivity hubs and brain networks.
    Cereb Cortex,21(9):2003-13. Epub 2011 Jan 31, (2011 Sep).   PubMed
  • Tomasi D., and Volkow N.D.
    Aging and functional brain networks.
    Mol. Psychiatry, doi: 10.1038/mp.2011.81. [Epub ahead of print] (2011 Jul).  PubMed
  • Tomasi D., and Volkow N.D.
    Functional connectivity hubs in the human brain.
    Neuroimage, 57(3):908-17. Epub 2011 May 14. (2011 Aug).  PubMed
  • Tomasi D.and Volkow N.D.
    Gender differences in brain functional connectivity density.
    Hum Brain Mapp., doi: 10.1002/hbm.21252. [Epub ahead of print] (2011)  PubMed
  • Tomasi D., and Volkow N.D.
    Laterality Patterns of Brain Functional Connectivity: Gender Effects.
    Cereb Cortex. [Epub ahead of print] (2011 Aug)   PubMed
  • Tomasi D., Volkow N.D., Wang G.J., Wang R., Telang F., Caparelli E.C., Wong C., Jayne M., and Fowler J.S.
    Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls.
    Neuroimage, 54:3101-3110 (2011).   PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Fowler J.S., Telang F., Goldstein R.Z., Alia-Klein N., Woicik P., Wong C., Logan J., Millard J., and Alexoff D.
    Positive Emotionality is Associated with Baseline Metabolism in Orbitofrontal Cortex and in Regions of the Default Network.
    Mol. Psychiatry, 16(8):818-25. doi: 10.1038/mp.2011.30. Epub 2011 Apr 12, (2011 Aug)  PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Fowler J.S., Telang F., Goldstein R.Z., Alia-Klein N., and Wong C.
    Reduced Metabolism in Brain “Control Networks” Following Cocaine-Cues Exposure in Female Cocaine Abusers.
    PLoS One, 6(2):e16573 (2011).   PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Vaska P., Fowler J.S., Telang F., Alexoff D., Logan J., and Wong C.
    Effects of Cell Phone Radiofrequency Signal Exposure on Brain Glucose Metabolism.
    JAMA, 305:808-813 (2011).   PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., and Baler R.
    Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction.
    Curr. Top Behav. Neurosci., [Epub ahead of print] (2011 Oct).   PubMed
  • Volkow N.D., Wang G.J., Fowler J.S, Tomasi D., and Telang F.
    Addiction: Beyond Dopamine Reward Circuitry.
    Proc. Natl. Acad. Sci. U.S.A., 108(37):15037-42. Epub 2011 Mar 14, (2011 Sep).  PubMed
  • Wang G.J., Smith L., Volkow N.D., Telang F., Logan J., Tomasi D., Wong C.T., Hoffman W., Jayne M., Alia-Klein N., Thanos P., and Fowler J.S.
    Decreased dopamine activity predicts relapse in methamphetamine abusers.
    Mol. Psychiatry, doi: 10.1038/mp.2011.86. [Epub ahead of print] (2011 Jul).  PubMed
  • Asensio S., Romero M.J., Romero F.J., Wong C.T., Alia-Klein N., Tomasi D., Wang G.-J., Telang F., Volkow N.D., Goldstein R.Z.
    Striatal dopamine D2 receptor availability predicts the thalamic and medial prefrontal responses to reward in cocaine abusers three years later.
    SYNAPSE, 64(5):397-402 (2010).  PubMed
  • Goldstein R.Z., Woicik P.A., Maloney T., Tomasi D., Alia-Klein N., Shan J., Honorio J., Samaras D., Wang R., Telang F., Wang G.J., and Volkow N.D.
    Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task.
    Proc. Natl. Acad. Sci. (USA), 107(38):16667-16672 (2010).  PubMed
  • Tomasi D. and Volkow N.D.
    Functional Connectivity Density Mapping.
    Proc. Natl. Acad. Sci. USA, 107:9885-9890 (2010).   PubMed
  • Tomasi D., Volkow N.D., Wang R., Carrillo J., Maloney T., Alia-Klein N., Woicik P.A., Telang F., Goldstein R.Z.
    Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers.
    PLOS ONE, 5(5):E10815 (2010).  PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Fowler J.S., Telang F., Wang R., Alexoff D., Logan J., Wong C., Pradhan K., Caparelli E.C., Ma Y., and Jayne M.
    Effects of low-field magnetic stimulation on brain glucose metabolism.
    Neuroimage 51: 623-628 (2010).   PubMed
  • Volkow N.D., Wang G.-J., Fowler J.S., Tomasi D., Telang F., and Baler R.
    Addiction: Decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain’s control circuit.
    Bioessays, 32(9):748-755 (2010).  PubMed
  • Volkow N.D., Wang G.-J., Tomasi D., Telang F., Fowler J.S., Pradhan K., Jayne M., Logan J., Goldstein R.Z., Alia-Klein N., Wong C.T.
    Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers.
    PLOS ONE, 5(7):e1150-e1159 (2010).  PubMed
  • Wang R., Wang G.J., Goldstein R.Z., Caparelli E.C., Volkow N.D., Fowler J.S., and Tomasi D.
    Induced magnetic force in human heads exposed to 4 T MRI.
    Journal of Magnetic Resonance Imaging, 31(4):815-820 (2010).  PubMed
  • Alia-Klein N., Goldstein R.Z., Tomasi D., Woicik P., Moeller S.J., Williams B., Craig I.W., Telang F., Biegon A., Wang G.J., Fowler J.S., and Volkow N.D.
    Neural Mechanisms of Anger Regulation as a Function of Genetic Risk for Violence.
    Emotion, 9:385-396 (2009).   PubMed
  • Goldstein R.Z., Carrillo J.H., Alia-Klein N., Tomasi D., Maloney T., Woicik P., Wang R.L., Telang F., and Volkow N.D.
    Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. Proc. Natl. Acad. Sci. USA, 106:9453-9458 (2009).   PubMed
  • Goldstein R.Z., Tomasi D., Alia-Klein N., Carrillo J.H., Maloney T., Woicik P., Wang R.L., Telang F., and Volkow N.D.
    Dopaminergic response to drug words in cocaine addiction.
    J Neurosci., 29:6001-6006 (2009).   PubMed
  • Mujica-Parodi L.R., Korgaonkar M., Ravindranath B., Greenberg T., Tomasi D., Wagshul M., Ardekani B., Guilfoyle D., Kilpatrick J., Sedler M., and Malaspina D.
    Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults.
    Hum Brain Mapp, 30:47-58 (2009).   PubMed
  • Tomasi D., Volkow N.D., Wang R.L., Telang F., Wang G.J., and Fowler J.S.
    Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention.
    PLoS ONE, 4:e610 (2009).   PubMed
  • Tomasi D., Wang G.J., Wang R.L., Backus W., Geliebter A., Telang F., Jayne M.C., Wong C., Fowler J.S., and Volkow N.D.
    Association of body mass and brain activation during gastric distention: implications for obesity.
    PLoS ONE, 4:e6847 (2009).   PubMed
  • Tomasi D., Wang R., Telang F., Boronikolas V., Jayne M.C., Wang G.J., Fowler J.S., and Volkow N.D.
    Impairment of attentional networks after 1 night of sleep deprivation.
    Cereb Cortex, 19:233-240 (2009).   PubMed
  • Volkow N.D., Tomasi D., Wang G.J., Telang F., Fowler J.S., Wang R.L., Logan J., Wong C., Jayne M., and Swanson J.M.
    Hyperstimulation of Striatal D2 Receptors with Sleep Deprivation: Implications for Cognitive Impairment.
    Neuroimage, 45:1232-1240 (2009).   PubMed
  • Alia-Klein N., Goldstein R.Z., Kriplani A., Logan J., Tomasi D., Williams B., Telang F., Shumay E., Biegon A., Craig I.W., Henn F., Wang G.-J., Volkow N.D., and Fowler J.S.
    Brain monoamine oxidase A activity predicts trait aggression.
    J Neurosci 28: 5099-5104 (2008).   PubMed
  • Alia-Klein N., Kriplani A., K. Pradhan, Ma J.Y., Logan J. , Williams B., Craig I.W., Telang F., Tomasi D., Goldstein R.Z., Wang G.J., Volkow N.D., and Fowler J.S.
    The MAO A genotype does not modulate resting brain metabolism in adults.
    Psychiatry Res., 164:73-76 (2008).   PubMed
  • Caparelli E.C. and Tomasi D.
    k-Space spatial low-pass filters can increase signal loss artifacts in echo-planar imaging. Biomed Signal Proc & Control, 3:107-114, 2008.   PubMed
  • Junnarkar S.S., Fried J., Southekal S., Pratte J.-F., O’Connor P., Radeka V., Vaska P., Purschke M., Tomasi D., Woody C., and Fontaine R.
    Next generation of real time data acquisition, calibration and control system for the RatCAP scanner.
    IEEE Trans. Nuc. Sci., 55:220-224 (2008).
  • Tomasi D., Chang L., Caparelli E.C., and Ernst T.
    Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks.
    Neurosci., 151:1006-1015 (2008).   PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Logan J., Wong C., Ma Y., Pradhan K., Tomasi D., Ferré S., and Jayne M.
    Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain.
    J Neurosci., 28:8454-8461 (2008).   PubMed
  • Wang G.J., Tomasi D., Backus W., Wang R., Telang F., Geliebter A., Korner J., Baumann A., Fowler J.S., and Thanos P.K.
    Gastric Distention Activates Satiety Circuitry in the Human Brain.
    Neuroimage, 39:1824-1831 (2008).   PubMed
  • Alia-Klein N., Goldstein R.Z., Tomasi D., Zhang L., Telang F., Wang G.-J., Fowler J.S., and Volkow N.D.
    What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex.
    Emotion, 7:649-659 (2007).   PubMed
  • Goldstein R.Z., Alia-Klein N., Tomasi D., Zhang L., Cottone L.A., Maloney T., Telang F., Caparelli E.C., Chang L., Ernst T., Samaras D., Squires N.K., and Volkow N.D.
    Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction.
    Am. J. Psychiatry, 164:43-51 (2007).   PubMed
  • Goldstein R.Z., Tomasi D., Alia-Klein N., Cottone L.A., Zhang L., Telang F., and Volkow N.D.
    Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers.
    Drug Alcohol Depend., 87:233-240 (2007).   PubMed
  • Goldstein R.Z., Tomasi D., Alia-Klein N., Zhang L., Telang F., and Volkow N.D.
    The effect of practice on a sustained attention task in cocaine abusers. Neuroimage, 35:194-206 (2007).   PubMed
  • Goldstein R.Z., Tomasi D., Rajaram S., Cottone L.A., Zhang L., Maloney T., Telang F., Alia-Klein N., and Volkow N.D.
    Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction.
    Neurosci., 144:1153-1159 (2007).   PubMed
  • Tomasi D., Chang L., Caparelli E.C., and Ernst T.
    Different activation patterns for working memory load and visual attention load.
    Brain Res., 1132:158-165 (2007).   PubMed
  • Tomasi D.G., and Caparelli E.C.
    Macrovascular contribution in activation patterns of working memory. J. Cereb. Blood Flow Metab., 27:33-42 (2007).   PubMed
  • Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C., and Volkow N.D.
    Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception.
    Psych. Res. Neuroimaging, 155:189-201 (2007).   PubMed
  • Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C., and Volkow N.D.
    Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence.
    Brain Res., 1171:83-92 (2007).   PubMed
  • Tomasi D.G., and Wang R.
    Induced magnetic field gradients and forces in the human head in MRI.
    J Magn Reson Imaging, 26:1340-1345 (2007).   PubMed
  • Woody C., Schlyer D., Vaska P., Tomasi D., Solis-Najera S., Rooney W., Pratte J.F., Junnarkar S., Stoll S., Master Z., Purschke M., Park S.J., Southekal S., Kriplani A., Krishnamoorthy S., Maramraju S., O'Connor P., and Radeka V.
    Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomography. Nucl. Inst. Met. Phys. Res., A571:102-105 (2007).
  • Tomasi D., Chang L., Caparelli E.C., Telang F., and Ernst T.
    The human inmmunodeficiency virus reduces network capacity: acoustic noise effect.
    Ann. Neurol., 59:419-423 (2006).   PubMed
  • Tomasi D., Ernst T., Caparelli E.C., and Chang L.
    Common deactivation patterns during working memory and visual attention tasks: An intra-subject fMRI study at 4 Tesla.
    Human Brain Mapp, 27:694-705 (2006).   PubMed
  • Wang G-J., Yang J., Volkow N.D., Telang F., Ma Y., Zhu W., Wong C.T., Tomasi D., and Fowler J.S.
    Gastric stimulation activates brain satiety circuit in obese subjects.
    Proc. Natl. Acad. Sci. USA, 103:15641-15645 (2006).   PubMed
  • Caparelli E.C., Tomasi D., and Ernst T.
    The Effect of Small Rotations on R2* with Echo Planar Imaging. NeuroImage, 24:1164-1169 (2005).   PubMed
  • Foerster B., Tomasi D., and Caparelli E.C.
    Magnetic Field Shift due to Mechanical Vibration in Functional MRI.
    Magn. Reson. Med., 54:1261-1267 (2005).   PubMed
  • Tomasi D., Caparelli E.C., Chang L., and Ernst T.
    fMRI-acoustic noise alters brain activation during working memory tasks.
    NeuroImage, 27:377-386 (2005).   PubMed
  • Chang L., Tomasi D., Yakupov R., Lozar C., Arnold S., Caparelli E.C., and Ernst T.
    Adaptation of the Attention Network in Human Immunodeficiency Virus Brain Injury.
    Ann. Neurol., 56:259-272 (2004).   PubMed
  • Tomasi D., Ernst T., Caparelli E.C., and Chang L.
    Practice-induced changes of brain function during visual attention: A parametric fMRI study at 4 Tesla.
    NeuroImage, 23:1414-1421 (2004).   PubMed
  • Caparelli E., Tomasi D., Arnold S.,Chang L., and Ernst T.
    k-Space Based Motion Detection for fMRI.
    NeuroImage, 20(2):1411-1418 (2003).  PubMed
  • Tomasi D.G., and Ernst T.
    Echo Planar Imaging at 4T with Minimum Acoustic Noise.
    J. Magn. Reson. Imaging, 18:128-30 (2003).   PubMed
  • Tomasi D., Xavier R.F., Foerster B., Panepucci H., Tannus A., and Vidoto E.
    Asymmetrical Gradient Coil for Head Imaging.
    Magn. Reson. Med., 48(4):707-714 (2002).  PubMed
  • Tomasi D.
    Stream Function Optimization for Gradient Coil Design.
    Magn. Reson. Med., 45(3):505-512 (2001).  PubMed
  • Caparelli E.C., Tomasi D. and Panepucci H.
    Shielded Biplanar Gradient Coil Design.
    J. Magn. Reson. Imaging, 9(5):725-731 (1999).  PubMed
  • Tomasi D., Caparelli E.C., H. Panepucci and B. Foerster. Fast Optimization of a Biplanar Gradient Coil Set. J Magn Reson 140: 325-339 (1999).   PubMed
  • Tomasi D. and Panepucci H.
    Magnetic Fields Mapping with the Phase Reference Method.
    Magn Reson Imaging, 17(1):157-160 (1998).  PubMed
  • Tomasi D., Panepucci H., Vidoto E.L., and Ribeiro Azevedo E.
    Use of a Phase Reference for Field Mapping with Amplitude Images at Low Field.
    J. Magn. Reson., 131(2):310-314 (1998).  PubMed