Macromolecular and Nanomaterial Synthesis & Assembly

Contact: Oleg Gang

Capabilities include techniques and methods required for the synthesis, fabrication and study of novel hybrid structures and functionalities using regulated nanoscale assembly and self-organization approaches. Capabilities and expertise include solution-based synthesis and characterization of a variety of soft, biological, hybrid and inorganic nanomaterials, advanced functionalization routes for surfaces and nano-objects, and selective biomolecular recognition.

Capabilities also provide broad support for the construction of DNA and protein based nanostructures, nano-scaffolds, and nano-machines and targeted software for DNA structure and sequence design. Preparative capabilities include gel-based DNA purification, conventional and real-time PCR for DNA amplification, as well as wet-lab facilities for preparing DNA and protein derivatives. Solution phase analysis is available via gel or UV-absorption studies from room temperature up to 80ºC. The range of structure characterization techniques is available in our Structural Probing capability.

Capabilities

• FTIR spectrometer; Thermo Scientific Nicolet 6700
  Contact: Mathew Maye
  The apparatus features motorized Pike Veemax II specular reflectance accessory and Smart MIRacle horizontal attenuated total reflectance (HATR) accessory



• Circular dichroism; Jasco J-815
  Contact: Soo-Kwan Lee
  Measures Circular Dichroism/ UV/Visible absorbance, Linear Dichroism/ Oriented molecules, Fluorescence detected CD and Total Fluorescence in the range 163 to 900 nm.



• UV-Vis/NIR spectrophotometer; PerkinElmer Lambda 35
  Contact: Mathew Maye
  Spectrophotometer with temperature control capabilities operates in the range 175 – 900 nm.



• Fast Protein Liquid Chromatography (FPLC) AKTA Explorer 100GE Healthcare
  Contact: Kumara Mudalige
  Chromatography system works with sample loads from micrograms to grams. Systems can be selected to use flow rates up to 100 ml/min (pressure 10 MPa) or up to 10 ml/min (pressure 25 MPa), ensuring optimum running conditions for all high-performance media.



• DNA Capabilities
  Contact: William Sherman
  Includes real-time Roche Lightcycler 480 Polymerase Chain Reaction (PCR) system, microarray hybridization and analysis, Biorad gel-imaging system.



• Labmaster 130 automated glovebox
  Contact: Mathew Maye



• Wet chemistry lab equipped for Nanomaterials synthesis
  Contact: Mathew Maye

Last Modified: May 6, 2008
Please forward all questions about this site to: Stephen Giordano.

One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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