Center for Functional Nanomaterials Seminar
"Nano-Building Block Toolboxes ("Nano-Toolboxes") for Self-Assembly of Nanocomposites with Arbitrary Shapes and Functions"
Presented by Jin-Woo Kim, University of Arkansas
Monday, March 18, 2013, 11 am
Bldg. 735 - Conf Rm A
Hosted by: Oleg Gang
Engineering multiple nanoscale particles (NPs) into single multifunctional structure with predefined biophysicochemical characteristics has the potential to transform many fields of research, ranging from optoelectronics and nanophotonics to nanomedicine. Self-assembly has emerged as a powerful and practical strategy for controlled synthesis of composites of NPs. Despite the promise and recent progress in DNA- directed NP self-assembly, the accurate, scalable, and high-rate assembly of heterogeneous nanocomponents into multifunctional nano-architecture with specifically designed shapes and sizes remains a challenge in the field of nanotechnology. The difficulty is to control the assembly process in order for the designed structure to be constructed with minimum unwanted products and artifacts. To meet the challenge, our group is in the process of developing nano-building block toolboxes (nano-toolboxes) for the programmable self-assembly of nanostructures with arbitrary shapes and arbitrary functions. This is accomplished with our novel anisotropic monofunctionalization technology that enables controls over the number, placement, and orientation of the DNA on various NPs.1-6 By functionalizing DNA one at a time to NP, a DNA-NP building block could have distinct DNA sequences at different locations on the surface of the particle. Since this technology could incorporate NPs of different composition, generating nano-toolboxes of various NPs with DNA at defined locations and in defined 3D orientations on a NP, it promises not only complicated shapes, but also the ability to tune the function of the assembly. This presentation will discuss the challenges to programmable and scalable self-organization of NP nano-architectures with specific shape and function, and present our strategies to realize the control and functionality necessary to overcome the challenges. Also it will discuss the future perspecti