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Past MPSA Meetings
The MPSA conferences began in 1974 with a small workshop
in Boston, MA, USA organized by Richard A. Laursen, Boston University,
for the purpose of exchanging information on the then new chemistry
for sequencing proteins by removing amino acids from the amino terminus
one at a time.
This chemical scheme was developed principally by Pehr
Edman, at the Rockefeller Institute, the University of Lund, Sweden,
and finally at the St. Vincent School of Medical Research in Melbourne,
Australia. Subsequent workshops have been held approximately every
two years and have alternated between Europe, Japan and the United
States. As techniques for protein analysis increased in the early
1990s, the workshops expanded in scope and size to emphasize additional
aspects of protein structure analysis as well as chemistries related
to primary sequence analysis.
The focus of the conferences has remained,
however, on sharing cutting edge techniques for protein analysis.
In 1999, The International Association for Protein Structure Analysis
and Proteomics (IAPSAP) was founded, in large part to facilitate
organizing
future MPSA conferences. A summary of the 14 Workshops/Conferences
held to date is given below.
Reflections on the MPSA-Conferences:
Development and Innovations of Protein and Peptide Structure Analysis
in the Past 30 Years
Brigitte Wittmann-Liebold
Autumn, 2005
Reflections is a personal account of developments in protein
chemistry and protein structure analysis as seen through the Methods in
Protein Structure Analysis (MPSA) workshops and conferences from their
beginning with the small workshop in Boston, Massachusetts in 1975
through the founding of the International Association for Protein
Structure Analysis and Proteomics (IAPSAP) in 1999 and MPSA2004, held in
Seattle, Washington. Dr. Wittman-Liebold organized MPSA1988 in Berlin,
Germany, attended each of previous and subsequent MPSA conferences, and
served as an original member of Board of Directors of IAPSAP.
MPSA1975, Boston, Massachusetts, USA,
May 21-23, 1975, 1st MPSA Conference.
Organizer: Richard A. Laursen, Boston University.
Publication: Solid Phase Methods in Protein Sequence
Analysis (Proceedings of the First International Conference), R.A.Laursen
(Ed.), Pierce Chemical Co Press, Rockford, IL,1975, 286 pp.
MPSA1977, Montpellier, France, September 21-23, 1977,
2nd MPSA Conference.
Organizer: M. A. Coletti-Previero, Unite de Recherches,
INSERM, Montpellier, France.
Publication: Solid Phase Methods in Protein Sequence
Analysis (Proceedings of the 2nd International Conference on Solid Phase
Methods in Protein Sequence Analysis), A. Previero and M. A. Coletti-Previero
(Eds.), Elsevier/N.Holland Biomedical Press, Amsterdam, 1977, 298 pp.
MPSA1979, Heidelberg, Germany, October 1-4, 1979,
3rd MPSA Conference.
Organizer: Christian Birr, Max-Planck-Institut für
Medizinische Forschung, Heidelberg, Germany.
Publication: Methods in Peptide and Protein Sequence
Analysis. (Proceedings of the 3rd International Conference on Solid
Phase Methods in Protein Sequence Analysis), C. Birr (Ed.), Elsevier/N.Holland
Biomedical Press, Amsterdam, 1980, 531 pp.
MPSA1981, Brookhaven, New York, USA, September
21-25, 1981, 4th MPSA Conference.
Organizer: Marshall Elzinga, Brookhaven National Laboratory,
Upton, NY USA.
Publication: Methods in Protein Sequence Analysis.
(Proceedings of the 4th International Conference on Methods in Protein
Sequence Analysis), M. Elzinga (Ed.), Humana Press, Clifton, NJ, USA,
1982, 589 pp.
MPSA1984, Cambridge, United Kingdom, July 29 –
August 2, 1984, 5th MPSA Conference.
Organizer: John Walker, Medical Research Council, Cambridge,
U.K.
MPSA1986, Seattle, Washington, USA, August 17-21,
1986, 6th MPSA Conference.
Organizer: Kenneth A. Walsh, University of Washington,
Seattle, USA..
Publication: Methods in Protein Sequence Analysis -
1986 (Proceedings of the 6th International MPSA Conference, Seattle,
WA), Kenneth A. Walsh (Ed.), Humana Press, Clifton, New Jersey, 1987,
658 pp.
MPSA1988, Berlin, Germany, July 3-8, 1988, 7th MPSA
Conference.
Organizer: Brigitte Wittmann-Liebold, Max-Planck-Institut
für Molekulare Genetik, Berlin, Germany.
Publication: Methods in Protein Sequence Analysis (Proceedings
of the 7th International Conference, Berlin, July 3-8, 1988), B. Wittmann-Liebold
(Ed.), Springer-Verlag, Berlin, 1989, 575 pp.
Pehr Edman Award (First): Richard A. Laursen, Boston
University, Boston, Massachusetts, USA; for contributions to solid-phase
protein sequencing; Sponsor: Milligen Division of the Millipore
Corporation.
MPSA1990, Kiruna, Sweden, July 1-6, 1990, 8th MPSA
Conference.
Organizer: Hans Jörnvall, Karolinska Institutet,
Stockholm, Sweden.
Publication: Methods in Protein Sequence Analysis,
H. Jörnvall, J.-O. Höög, and A. M. Gustavsson (Eds.),
Birkhäuser Verlag, Basel, Switzerland, 1991, 396 pp.
Pehr Edman Award: Dr.Geoffrey Begg, Ludwig Institute
for Cancer Research and Dr. Brigitte Wittmann-Liebold, Max Delbrück
Center for Molecular Medicine, for pioneering contributions to the methodology
of protein sequencing analysis. Sponsor: Milligen/Biosearch Division
of the Millipore Corporation.
MPSA1992, Otsu, Japan, September 20-24,1992, 9th MPSA
Conference.
Organizer: Kazutomo Imahori
Publication: Abstracts and Short Communications. J.
Protein Chem. 11 (1992) 347-432; Special Issue.
Book : Methods in Protein Sequence Analysis, (Proceedings of the 9th
International Conference on Methods in Protein Sequence Analysis), K.
Imahori and F. Sakiyama (Eds.), Plenum Press, New York, 1993, p.310.
Pehr Edman Award: Dr. Donald Hunt, University of Virginia,
and Dr. Klaus Biemann, Department of Chemistry, MIT, MA, for developments
in mass spectrometry. Sponsor: Millipore Corporation.
MPSA1994, Snowbird, Utah, USA, September 8-13, 1994,
10th MPSA Conference.
Organizer: M. Zouhair Atassi, Houston, Texas USA.
Publications: Abstracts: J. Protein Chem. 13 (1994)
433-545; Special Issue: Abstracts and Short Communications.
Book: Methods in Protein Structure Analysis (Proceedings of the 10th
International MPSA Conference, Snowbird, Utah), M. Z. Atassi and E.
Appella (Eds.), Plenum Press, New York, 1995, 534 pp.
Pehr Edman Award: Dr. Ruedi H. Aebersold, University
of Washington, Seattle, WA, USA and Dr. Joël Vandekerckhove, University
of Ghent, Belgium; for contributions to the sequencing of samples after
electrophoretic separations. Sponsor: Millipore Corporation.
MPSA1996, Annecy, France, September 1-5, 1996, 11th
MPSA Conference.
Organizers: Michel van der Rest, Director, Institute
de Biologie Structurale, Grenoble, France, and Joël Vandekerckhove,
University of Ghent, Belgium.
Publication: Vandekerckhove and J. and M. van der Rest
(Eds), J. Protein Chem. 16: 321-564, 1997; Special issue, Short communications
and abstracts.
Pehr Edman Award: Dr. Winona Barker, National Biomedical
Research Foundation, for the development of a comprehensive protein
classification database, and Dr. Jerker Porath, University of Uppsala,
for the development of affinity chromatographic methods. Sponsor:
Millipore Corporation.
MPSA1998, Halkidiki, Greece, September 5-10, 1998,
12th MPSA Conference.
Organizers: D. A. Kyriakidis and Theadora Choli-Papadopoulou,
Aristotle University of Thessaloniki, Thessaloniki, Greece.
Publications: Choli-Papadopoulou, Y. and D. A. Kyriakidis
(Eds.) J. Protein Chem. 17: 507-577, 1998; Special issue, Short communications
and abstracts.
Book: Proteome and Protein Analysis (Selected papers from MPSA 1998),
Kamp, R.M., Kyriakidis, D., Choli-Papadopoulou, T. (Eds.), Springer-Verlag,
Heidelberg, 2000, 372 pp.
Pehr Edman Award: Dr. Mathias Wilm, European Molecular
Biology Laboratory, Dr. Mathias Mann, University of Southern Denmark,
and Dr. John Yates, The Scripps Research Institute, for contributions
to the identification of proteins and protein complexes by mass spectrometry.
Sponsor: Millipore Corporation.
Incorporation of the International Association
for Protein Structure Analysis and Proteomics (IAPSAP);
in the Commonwealth of Virginia, September 14, 1999.
MPSA2000, Charlottesville, Virginia, USA, September
16-20, 2000, 13th MPSA Confernce.
Organizer: Jay Fox, University of Virginia, USA.
Publication: MPSA2000
[PDF] Appella, E., J. W. Fox, and C. W. Anderson. Meeting Report. Methods
in Protein Structural Analysis Conference (MPSA2000), Charlottesville,
Virginia, September 16-20, 2000, Protein Sci. 10 (2001) 459-461.
Pehr Edman Award: Leroy Hood, Systems Biology Institute,
Seattle, WA, and Michael Hunkapiller, Applied Biosystems, for development
of the automated, gas-phase protein sequencer. Sponsor: PE Applied
Biosystems.
MPSA Distinguished Postdoctoral Fellow Award (first): K. Muller, University
of California, Berkeley.
MPSA2002, Valencia, Spain, September 8-12, 2002, 14th
MPSA Confernce.
Organizer: Juan J. Calvete, Instituto de Biomedicina
de Valencia, Valencia, Spain
Publication: MPSA2002
[PDF]: Anderson, C. W. , J. Calvete, J. W. Fox, E. Appella. Meeting
Report: Methods in Protein Structural Analysis Conference (MPSA2002).
Protein Sci. 12 (2003) 398-400.
Pehr Edman Award: Prof. Hans Jörnvall,
Karolinska Institute, Stockholm, Sweden, for contributions to protein
chemistry, structure and function through the development of techniques
associated with the use of Edman chemistry and structure-function studies
on the alcohol dehydrogenases; and Emeritus Professor Kenneth Walsh,
University of Washington, Seattle, Washington, USA for contributions
to the development of mass spectrometry for the characterization of
the chemical structure of proteins and their posttranslational modifications
and concepts regarding the evolution of protein structure and function.
Sponsor: PE Applied Biosystems.
MPSA Distinguished Young Investigator Award (second): Dr. Dorothee Kern, Department of Biochemistry, Brandeis
University, Waltham, MA 02454, USA, for studies on the dynamic processes
that trigger protein function related to enzyme catalysis, ligand binding
and signaling events. Sponsor: PE Applied Biosystems.
MPSA2004, Seattle, Washington, USA, August 29 - September 2,
2004, 15th MPSA Conference.
Download Program
Book
Organizer: Ray Paxton, Amgen, Seattle, WA.
Publication:
MPSA2004 [PDF] Anderson, C. W., R. Paxton, J. W. Fox, and E. Appella. Meeting Report (MPSA2004). Protein Sci. 14(1) 272-275 (2005).
Pehr Edman Award:
Stephen Altschul, Computational Biology Branch, National Center for
Biotechnology Information, National Library of Medicine, National
Institutes of Health, USA, and Dr. Amos Bairoch, Swiss Institute for
Bioinformatics, Geneva, Switzerland, for their contributions to the
development of bioinformatics methods and databases for the analysis of
proteins and their structures.
Sponsor: PE Applied Biosystems.
IAPSAP
Distinguished Young Investigator Award (third): Dr. Niroshan
Ramachandran, Harvard Institute of Proteomics, Department of Biological
Chemistry and Molecular Pharmacology, Harvard University, Boston, MA
02115, USA, for the development of novel self-assembling protein
microarrays for the functional analysis of proteins. Sponsor:
PE Applied Biosystems.
MPSA2006, Lille, France, August 29 –
September 2, 2006, 16th MPSA Conference.
Download Program Book
(pdf)
Organizer: Guy Lippens, CNRS/University of Lille1,
France.
Publication:
MPSA2006 [PDF] Anderson, C. W., G. Lippens,
J.W. Fox, and E. Appella. Meeting Report: MPSA2006 (Methods
in Protein Structure Analysis 2006). Protein Sci. 16(2)350-354.
Pehr Edman Award: Dr. Fred W. McLafferty, Cornell University, Professor
Emeritus, for his pioneering work in mass spectrometry including gaseous
ion reactions (McLafferty rearrangement), instrumentation (GC/MS, LC/MS,
MS/MS), fragmentation techniques, and computer data acquisition,
reduction, and peptide identification; and Dr. Darryl Pappin, Advanced
Research and Technology Division of Applied Biosystems, for the
development of instruments and membrane-based supports for solid-phase
Edman sequencing.
Sponsors: Applied Biosystems, Inc. and Agilent Technologies.
IAPSAP Distinguished Young Investigator Award (fourth): Dr.
Benjamin G. Davis, Department of Chemistry, Oxford University, UK, for
the development of new methods for controlling the reactivity,
selectivity and specificity of oligosaccharide formation and the
installation of oligosaccharides into proteins. Sponsor: Agilent
Technologies.
MPSA2008, Sapporo, Japan, August 26 –
29, 2008, 17th MPSA Conference.
Download Program Book (pdf)
Organizer: Kazuyasu Sakaguchi, Hokkaido
University, Japan.
Pehr Edman Award: Dr. Ettore Appella (http://ccr.cancer.gov/staff/staff.asp?profileid=5715),
National Cancer Institute, NIH, for his work on deciphering the code
through which posttranslational modifications modulate the activity
of the p53 tumor suppressor and his contributions to characterizing
the interactions of the T-cell receptor (TCR) with class I molecules
of the major histocompatibility complex (MHC); and
Prof. Richard Perham (http://www.bioc.cam.ac.uk/uto/perham.html),
St. John’s College, Cambridge University, for his pioneering
contributions to the structural analysis of proteins, protein
complexes and filamentous viruses that have provided important
insights for their assembly and function and for the development of
techniques for protein modification.
Sponsors: Applied Biosystems, Inc. and
Waters Corporation.
IAPSAP Distinguished Young Investigator Award (fifth): Dr.
Andreas Ladurner
(http://www-db.embl.de/jss/EmblGroupsOrg/per_2728.html),
of the European Molecular Biology Laboratory, Heidelberg, Germany,
for his pioneering efforts to identify protein modules that
recognize post-translational modifications in histone proteins and
his protein engineering analysis of key components in the RNAi
pathway. Sponsor:
Agilent Technologies.
MPSA2010, Uppsala, Sweden, August 25 – 28, 2010, 18th MPSA
Conference.
Download
Program (pdf)
Organizer: Jan Johansson, Swedish University of
Agricultural Sciences, Uppsala, Sweden.
Pehr Edman Award:
Prof. Per Westermank, Department of Genetics and Pathology, Uppsala
University, SE-751 85 Uppsala, Sweden, for his work on the induction and
possible transmissibility of amyloid; and Prof. Gunilla T. Westermank,
Department of Medical Cell Biology, Uppsala University, SE-751 85 Uppsala,
Sweden, for her work on the characterization of amyloid deposits and their
implications for cell death and development of type 2 diabetes, and the
development of an amyloid model for human disease. Sponsor:
AB Sciex.
2010 Viktor Mutt Memorial Lecture: Dr. Birgitta Agerberth (http://ki.se/ki/jsp/polopoly.jsp?d=25294&l=en),
Department of Medical Biochemistry and Biophysics, Karolinska Institute,
DE-171 77 Stockholn, Sweden, for her pioneering research on the
identification of human antimicrobial peptides important for innate
immunity.
Last Modified: December 28, 2010
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