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Past MPSA Meetings

The MPSA conferences began in 1974 with a small workshop in Boston, MA, USA organized by Richard A. Laursen, Boston University, for the purpose of exchanging information on the then new chemistry for sequencing proteins by removing amino acids from the amino terminus one at a time.

This chemical scheme was developed principally by Pehr Edman, at the Rockefeller Institute, the University of Lund, Sweden, and finally at the St. Vincent School of Medical Research in Melbourne, Australia. Subsequent workshops have been held approximately every two years and have alternated between Europe, Japan and the United States. As techniques for protein analysis increased in the early 1990s, the workshops expanded in scope and size to emphasize additional aspects of protein structure analysis as well as chemistries related to primary sequence analysis.

The focus of the conferences has remained, however, on sharing cutting edge techniques for protein analysis. In 1999, The International Association for Protein Structure Analysis and Proteomics (IAPSAP) was founded, in large part to facilitate organizing future MPSA conferences. A summary of the 14 Workshops/Conferences held to date is given below.

Reflections on the MPSA-Conferences:
Development and Innovations of Protein and Peptide Structure Analysis in the Past 30 Years
Brigitte Wittmann-Liebold
Autumn, 2005

Reflections is a personal account of developments in protein chemistry and protein structure analysis as seen through the Methods in Protein Structure Analysis (MPSA) workshops and conferences from their beginning with the small workshop in Boston, Massachusetts in 1975 through the founding of the International Association for Protein Structure Analysis and Proteomics (IAPSAP) in 1999 and MPSA2004, held in Seattle, Washington. Dr. Wittman-Liebold organized MPSA1988 in Berlin, Germany, attended each of previous and subsequent MPSA conferences, and served as an original member of Board of Directors of IAPSAP.

MPSA1975, Boston, Massachusetts, USA, May 21-23, 1975, 1st MPSA Conference.
Organizer: Richard A. Laursen, Boston University.
Publication: Solid Phase Methods in Protein Sequence Analysis (Proceedings of the First International Conference), R.A.Laursen (Ed.), Pierce Chemical Co Press, Rockford, IL,1975, 286 pp.

MPSA1977, Montpellier, France, September 21-23, 1977, 2nd MPSA Conference.
Organizer: M. A. Coletti-Previero, Unite de Recherches, INSERM, Montpellier, France.
Publication: Solid Phase Methods in Protein Sequence Analysis (Proceedings of the 2nd International Conference on Solid Phase Methods in Protein Sequence Analysis), A. Previero and M. A. Coletti-Previero (Eds.), Elsevier/N.Holland Biomedical Press, Amsterdam, 1977, 298 pp.

MPSA1979, Heidelberg, Germany, October 1-4, 1979, 3rd MPSA Conference.
Organizer: Christian Birr, Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.
Publication: Methods in Peptide and Protein Sequence Analysis. (Proceedings of the 3rd International Conference on Solid Phase Methods in Protein Sequence Analysis), C. Birr (Ed.), Elsevier/N.Holland Biomedical Press, Amsterdam, 1980, 531 pp.

MPSA1981, Brookhaven, New York, USA, September 21-25, 1981, 4th MPSA Conference.
Organizer: Marshall Elzinga, Brookhaven National Laboratory, Upton, NY USA.
Publication: Methods in Protein Sequence Analysis. (Proceedings of the 4th International Conference on Methods in Protein Sequence Analysis), M. Elzinga (Ed.), Humana Press, Clifton, NJ, USA, 1982, 589 pp.

MPSA1984, Cambridge, United Kingdom, July 29 – August 2, 1984, 5th MPSA Conference.
Organizer: John Walker, Medical Research Council, Cambridge, U.K.

MPSA1986, Seattle, Washington, USA, August 17-21, 1986, 6th MPSA Conference.
Organizer: Kenneth A. Walsh, University of Washington, Seattle, USA..
Publication: Methods in Protein Sequence Analysis - 1986 (Proceedings of the 6th International MPSA Conference, Seattle, WA), Kenneth A. Walsh (Ed.), Humana Press, Clifton, New Jersey, 1987, 658 pp.

MPSA1988, Berlin, Germany, July 3-8, 1988, 7th MPSA Conference.
Organizer: Brigitte Wittmann-Liebold, Max-Planck-Institut für Molekulare Genetik, Berlin, Germany.
Publication: Methods in Protein Sequence Analysis (Proceedings of the 7th International Conference, Berlin, July 3-8, 1988), B. Wittmann-Liebold (Ed.), Springer-Verlag, Berlin, 1989, 575 pp.
Pehr Edman Award (First): Richard A. Laursen, Boston University, Boston, Massachusetts, USA; for contributions to solid-phase protein sequencing; Sponsor: Milligen Division of the Millipore Corporation.

MPSA1990, Kiruna, Sweden, July 1-6, 1990, 8th MPSA Conference.
Organizer: Hans Jörnvall, Karolinska Institutet, Stockholm, Sweden.
Publication: Methods in Protein Sequence Analysis, H. Jörnvall, J.-O. Höög, and A. M. Gustavsson (Eds.), Birkhäuser Verlag, Basel, Switzerland, 1991, 396 pp.
Pehr Edman Award: Dr.Geoffrey Begg, Ludwig Institute for Cancer Research and Dr. Brigitte Wittmann-Liebold, Max Delbrück Center for Molecular Medicine, for pioneering contributions to the methodology of protein sequencing analysis. Sponsor: Milligen/Biosearch Division of the Millipore Corporation.

MPSA1992, Otsu, Japan, September 20-24,1992, 9th MPSA Conference.
Organizer: Kazutomo Imahori
Publication: Abstracts and Short Communications. J. Protein Chem. 11 (1992) 347-432; Special Issue.
Book : Methods in Protein Sequence Analysis, (Proceedings of the 9th International Conference on Methods in Protein Sequence Analysis), K. Imahori and F. Sakiyama (Eds.), Plenum Press, New York, 1993, p.310.
Pehr Edman Award: Dr. Donald Hunt, University of Virginia, and Dr. Klaus Biemann, Department of Chemistry, MIT, MA, for developments in mass spectrometry. Sponsor: Millipore Corporation.

MPSA1994, Snowbird, Utah, USA, September 8-13, 1994, 10th MPSA Conference.
Organizer: M. Zouhair Atassi, Houston, Texas USA.
Publications: Abstracts: J. Protein Chem. 13 (1994) 433-545; Special Issue: Abstracts and Short Communications.
Book: Methods in Protein Structure Analysis (Proceedings of the 10th International MPSA Conference, Snowbird, Utah), M. Z. Atassi and E. Appella (Eds.), Plenum Press, New York, 1995, 534 pp.
Pehr Edman Award: Dr. Ruedi H. Aebersold, University of Washington, Seattle, WA, USA and Dr. Joël Vandekerckhove, University of Ghent, Belgium; for contributions to the sequencing of samples after electrophoretic separations. Sponsor: Millipore Corporation.

MPSA1996, Annecy, France, September 1-5, 1996, 11th MPSA Conference.
Organizers: Michel van der Rest, Director, Institute de Biologie Structurale, Grenoble, France, and Joël Vandekerckhove, University of Ghent, Belgium.
Publication: Vandekerckhove and J. and M. van der Rest (Eds), J. Protein Chem. 16: 321-564, 1997; Special issue, Short communications and abstracts.
Pehr Edman Award: Dr. Winona Barker, National Biomedical Research Foundation, for the development of a comprehensive protein classification database, and Dr. Jerker Porath, University of Uppsala, for the development of affinity chromatographic methods. Sponsor: Millipore Corporation.

MPSA1998, Halkidiki, Greece, September 5-10, 1998, 12th MPSA Conference.
Organizers: D. A. Kyriakidis and Theadora Choli-Papadopoulou, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Publications: Choli-Papadopoulou, Y. and D. A. Kyriakidis (Eds.) J. Protein Chem. 17: 507-577, 1998; Special issue, Short communications and abstracts.
Book: Proteome and Protein Analysis (Selected papers from MPSA 1998), Kamp, R.M., Kyriakidis, D., Choli-Papadopoulou, T. (Eds.), Springer-Verlag, Heidelberg, 2000, 372 pp.
Pehr Edman Award: Dr. Mathias Wilm, European Molecular Biology Laboratory, Dr. Mathias Mann, University of Southern Denmark, and Dr. John Yates, The Scripps Research Institute, for contributions to the identification of proteins and protein complexes by mass spectrometry. Sponsor: Millipore Corporation.

Incorporation of the International Association for Protein Structure Analysis and Proteomics (IAPSAP); in the Commonwealth of Virginia, September 14, 1999.

MPSA2000, Charlottesville, Virginia, USA, September 16-20, 2000, 13th MPSA Confernce.
Organizer: Jay Fox, University of Virginia, USA.
Publication: MPSA2000 [PDF] Appella, E., J. W. Fox, and C. W. Anderson. Meeting Report. Methods in Protein Structural Analysis Conference (MPSA2000), Charlottesville, Virginia, September 16-20, 2000, Protein Sci. 10 (2001) 459-461.
Pehr Edman Award: Leroy Hood, Systems Biology Institute, Seattle, WA, and Michael Hunkapiller, Applied Biosystems, for development of the automated, gas-phase protein sequencer. Sponsor: PE Applied Biosystems.
MPSA Distinguished Postdoctoral Fellow Award (first): K. Muller, University of California, Berkeley.

MPSA2002, Valencia, Spain, September 8-12, 2002, 14th MPSA Confernce.
Organizer: Juan J. Calvete, Instituto de Biomedicina de Valencia, Valencia, Spain
Publication: MPSA2002 [PDF]: Anderson, C. W. , J. Calvete, J. W. Fox, E. Appella. Meeting Report: Methods in Protein Structural Analysis Conference (MPSA2002). Protein Sci. 12 (2003) 398-400.
Pehr Edman Award: Prof. Hans Jörnvall, Karolinska Institute, Stockholm, Sweden, for contributions to protein chemistry, structure and function through the development of techniques associated with the use of Edman chemistry and structure-function studies on the alcohol dehydrogenases; and Emeritus Professor Kenneth Walsh, University of Washington, Seattle, Washington, USA for contributions to the development of mass spectrometry for the characterization of the chemical structure of proteins and their posttranslational modifications and concepts regarding the evolution of protein structure and function. Sponsor: PE Applied Biosystems.
MPSA Distinguished Young Investigator Award (second): Dr. Dorothee Kern, Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA, for studies on the dynamic processes that trigger protein function related to enzyme catalysis, ligand binding and signaling events. Sponsor: PE Applied Biosystems.

MPSA2004, Seattle, Washington, USA, August 29 - September 2, 2004, 15th MPSA Conference.
Download Program Book
Organizer: Ray Paxton, Amgen, Seattle, WA.
Publication: MPSA2004 [PDF] Anderson, C. W., R. Paxton, J. W. Fox, and E. Appella. Meeting Report (MPSA2004). Protein Sci. 14(1) 272-275 (2005).
Pehr Edman Award: Stephen Altschul, Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, USA, and Dr. Amos Bairoch, Swiss Institute for Bioinformatics, Geneva, Switzerland, for their contributions to the development of bioinformatics methods and databases for the analysis of proteins and their structures.
Sponsor: PE Applied Biosystems.
IAPSAP Distinguished Young Investigator Award (third): Dr. Niroshan Ramachandran, Harvard Institute of Proteomics, Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Boston, MA 02115, USA, for the development of novel self-assembling protein microarrays for the functional analysis of proteins. Sponsor: PE Applied Biosystems.

MPSA2006, Lille, France, August 29 – September 2, 2006, 16th MPSA Conference.
Download Program Book (pdf)
Organizer: Guy Lippens, CNRS/University of Lille1, France.
Publication: MPSA2006 [PDF] Anderson, C. W., G. Lippens, J.W. Fox, and E. Appella. Meeting Report: MPSA2006 (Methods in Protein Structure Analysis 2006). Protein Sci. 16(2)350-354.
Pehr Edman Award: Dr. Fred W. McLafferty, Cornell University, Professor Emeritus, for his pioneering work in mass spectrometry including gaseous ion reactions (McLafferty rearrangement), instrumentation (GC/MS, LC/MS, MS/MS), fragmentation techniques, and computer data acquisition, reduction, and peptide identification; and Dr. Darryl Pappin, Advanced Research and Technology Division of Applied Biosystems, for the development of instruments and membrane-based supports for solid-phase Edman sequencing.
Sponsors: Applied Biosystems, Inc. and Agilent Technologies.
IAPSAP Distinguished Young Investigator Award (fourth): Dr. Benjamin G. Davis, Department of Chemistry, Oxford University, UK, for the development of new methods for controlling the reactivity, selectivity and specificity of oligosaccharide formation and the installation of oligosaccharides into proteins. Sponsor: Agilent Technologies.

MPSA2008, Sapporo, Japan, August 26 – 29, 2008, 17th MPSA Conference.
Download Program Book (pdf)
Organizer: Kazuyasu Sakaguchi, Hokkaido University, Japan.
Pehr Edman Award: Dr. Ettore Appella (http://ccr.cancer.gov/staff/staff.asp?profileid=5715), National Cancer Institute, NIH, for his work on deciphering the code through which posttranslational modifications modulate the activity of the p53 tumor suppressor and his contributions to characterizing the interactions of the T-cell receptor (TCR) with class I molecules of the major histocompatibility complex (MHC); and Prof. Richard Perham (http://www.bioc.cam.ac.uk/uto/perham.html), St. John’s College, Cambridge University, for his pioneering contributions to the structural analysis of proteins, protein complexes and filamentous viruses that have provided important insights for their assembly and function and for the development of techniques for protein modification.
Sponsors: Applied Biosystems, Inc. and Waters Corporation.
IAPSAP Distinguished Young Investigator Award (fifth): Dr. Andreas Ladurner
(http://www-db.embl.de/jss/EmblGroupsOrg/per_2728.html), of the European Molecular Biology Laboratory, Heidelberg, Germany, for his pioneering efforts to identify protein modules that recognize post-translational modifications in histone proteins and his protein engineering analysis of key components in the RNAi pathway. Sponsor: Agilent Technologies.

MPSA2010, Uppsala, Sweden, August 25 – 28, 2010, 18th MPSA Conference.
Download Program (pdf)
Organizer: Jan Johansson, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Pehr Edman Award: Prof. Per Westermank, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden, for his work on the induction and possible transmissibility of amyloid; and Prof. Gunilla T. Westermank, Department of Medical Cell Biology, Uppsala University, SE-751 85 Uppsala, Sweden, for her work on the characterization of amyloid deposits and their implications for cell death and development of type 2 diabetes, and the development of an amyloid model for human disease. Sponsor: AB Sciex.
2010 Viktor Mutt Memorial Lecture: Dr. Birgitta Agerberth (http://ki.se/ki/jsp/polopoly.jsp?d=25294&l=en), Department of Medical Biochemistry and Biophysics, Karolinska Institute, DE-171 77 Stockholn, Sweden, for her pioneering research on the identification of human antimicrobial peptides important for innate immunity.

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Last Modified: December 28, 2010