Telephone: (631) 344-3604
Application of physiological and functional MRI techniques to brain
Recent and current research in Linda Chang’s laboratory has focused
on the application of advanced magnetic resonance imaging (MRI) and
spectroscopic (MRS) techniques to the study of various brain diseases. She
has also applied perfusion MRI, magnetization MRI, diffusion MRI, and
BOLD-fMRI to assess the effects of HIV-associated brain diseases
(including HIV dementia, cerebral toxoplasmosis and CNS lymphoma) and
substance abuse (particularly stimulant abuse such as cocaine, MDMA and
methamphetamine abuse). In addition, she is interested in applying
non-invasive imaging techniques as surrogate markers to evaluate
medication and treatment effects in the brains of patients with HIV and
those with addiction. Her ongoing research is funded by the National
Institute on Drug Abuse (NIDA), National Institute of Neurological
Disorders and Stroke (NINDS), National Institute on Mental Health (NIMH),
the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the
University AIDS Research Program in California.
Education & Concurrent Positions
B.Sc. University of Maryland, 1981; M.Sc. Georgetown University, 1982;
M.D. Georgetown University, 1986.
Chair, Medical Department, BNL.
Gender effects on persistent cerebral metabolite changes in the frontal
lobes of abstinent cocaine users. L. Chang, T. Ernst and C.M. Mehringer. American
Journal of Psychiatry 156, 716-722 (1999).
Cerebral metabolite changes correlate with clinical severity of HIV-1
cognitive motor complex. L. Chang, T. Ernst, M. Leonido-Yee, I. Walot and
E. Singer. Neurology 52, 100-108 (1999).
Perfusion MRI detects rCBF abnormalities in early stages of
HIV-cognitive motor complex. L. Chang, T. Ernst, O. Speck and M. Leonido-Yee.
Neurology 54, 389-396 (2000).