Avraham Dilmanian Scientist Telephone:  (631) 344-7696 e-mail:  dilmanian@bnl.gov

Research Interests

• Microbeam Radiation therapy 
• Monochromatic x-ray radiography
• CT Diffraction-enhanced radiography and CT
• Avraham Dilmanian’s work focuses on the use of x-ray beams from the National Synchrotron Light Source (NSLS) in radiation therapy and medical imaging. Microbeam radiation therapy (MRT), which uses arrays of parallel, microplanar slices of x-ray microbeams, each typically 50 µm thick and up to several centimeters high, typically spaced 200 µm apart, has shown two remarkable effects on laboratory vertebrates. First, single-fraction microbeam irradiation does not damage normal tissues at doses where conventional broad beams produce several tissue damage. Second, single-fraction MRT kills some types of malignant tumor models by irradiation from a single direction, at doses safe to normal tissues. The method is being further studied for its potential in radiotherapy. Dilmanian has been a pioneer in the filed of computed tomography (CT) using monochromatic x rays. His current research includes, first, development of bent-crystal monochromators for narrowing the x-ray energy spectrum in clinical angiography and CT, to be used in conjunction with new contrast agents based on gadolinium from Schering AG, Germany. Second, his group, together with Dr. Zhong Zhong of the NSLS, have been the first to implement, in the CT mode, the new mammography method "Diffraction-Enhance Imaging (DEI)". They plan to extend the method to higher-energy beams (40-100 keV) for whole-body radiography and CT.

 Education & Concurrent Positions

• B.S. Technion, Israel Institute of technology, 1970
• M.S. Technion, Israel Institute of Technology, 1973
• Ph.D. Massachusetts Institute of Technology, 1980
• Associate Scientist, Brookhaven National Laboratory, xxxx-present.

Selected Publications

• Dilmanian F., Romanelli P., Zhong Z., Wang R., Wagshul M. E., Kalef-Ezra J., Maryanski M. J., Rosen E. M., Anschel D.J.
  Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams array interlacing.
  European Journal of Radiology, 68(3 Suppl):S129-36. Epub Jul 7 (2008). PubMed
• Huo Q., Yuasa T., Akatsuka T., Takeda T., Wu J., Thet-Lwin T., Hyodo K., Dilmanian F.A.
  Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging.
  Optics Letters , 33(21):2494-2496 (2008). PubMed
• Takeda T., Wu J., Lwin T.-T., Huo Q., Yuasa T., Hyodo K., Dilmanian F.A., Akatsuka T.
  X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice.
  Synchrotron Radiation, 2009 Jan;16(Pt 1):57-62. Epub 2008 Nov 21. PubMed
• Hainfeld, J., Dilmanian, F.A., Slatkin, D.N., Smilowitz, H.M.
  Radiotherapy enhancement with gold particles.
  Journal of Pharmacy and Pharmacology, 60(8):977-985 (2008) PubMed
• Dilmanian F.A., Button T.M., Le Duc G., Zhong N., Peña L.A., Smith J.A.L., Martinez S.R., Bacarian T., Tammam J., Ren B., Farmer P.M., Kalef-Ezra J., Micca P.L., Nawrocky M.M., Niederer J.A., Recksiek F.P., Fuchs A. and Rosen E.M.
  Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy.
  Neuro-Oncology, 4(1):26-38 (2002).  PubMed
• Dilmanian F.A., Morris G.M., Le Duc G., Huang X., Ren B., Bacarian T., Allen J.C., Kalef-Ezra J., Orion I., Rosen E.M., Sandhu T., Sathé P., Wu X.Y., Zhong Z. and Shivaprasad H.L.
  Response of avian embryonic brain to spatially segmented x-ray microbeams.
  Cell. Mol. Biol., 47(3):485-493 (2001).  PubMed
• Dilmanian F.A., Zhong Z., Ren B., Wu X.Y., Chapman L.D., Orion I. and Thomlinson W.C.
  Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method.
  Phys. Med. Biol., 45(4):933-946 (2000).  PubMed
• Laissue J.A., Geiser G., Spanne P.O., Dilmanian F.A., Gebbers J.-O, Geiser M., Wu X.Y., Makar M., Micca P., Nawrocky M., Joel D.D. and Slatkin D.N.
  Neuropathology of ablation of rat gliosarcoma and contiguous brain tissue using a microplanar beam of synchrotron- wiggler generated x-rays.
  Int. J. Cancer, 78(5):654-660 (1998).  PubMed
• Dilmanian F.A., Wu X.-Y., Parsons E.C., Ren B., Kress J., Button T.M., Chapman L.D., Coderre J.A, Giron F., Greenber D., Krus D.J., Liang Z., Marcovici S., Petersen M.J., Roque C.T., Shleifer M., Slatkin D.N., Thomlinson W.C., Yamamoto K. and Zhong Z.
  Single- and dual-energy CT with monochromatic synchrotron x rays.
  Phys. Med. Biol., 42(2):371-387 (1997).  PubMed
• Slatkin D.N., Spanne P., Dilmanian F.A., Gebbers J.-O. and Laissue J.A.
  Subacute neuropathological effects on rats of microplanar beams of x rays from a synchrotron wiggler.
  Proc. Natl. Acad. Sci., 92(19):8783-8787 (1995).  PubMed
• Dilmanian F.A.
  Computed Tomography with Monochromatic X Rays.
  Am. J. Physiol. Imaging, 7(3-4):175-193 (1992).  PubMed

Last Modified: May 7, 2009
Please forward all questions about this site to: Denise Monteleone

One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

Privacy and Security Notice  | Contact Web Services for help