Telephone: (631) 344-2965
Congwu Du is trained as a biomedical engineer with over 10 years in the
application of optical spectroscopy for characterization and detection of
physiological processes in tissue. Her current projects include the
simultaneous detection of the cerebral blood volume and oxygenation as
well as intracellular calcium in vivo using visible fluorescence
spectroscopy and photon migration techniques. She is the manager of 9.4T
MicroMRI facility in Medical Department. Her long-term goal is to combine
optical imaging with MRI for the diagnosis of diseases.
Education & Concurrent Positions
B.Sc. Huazhong Univ. of Science and Technology, China, 1985 (Laser
M.Sc. Huazhong Univ. of Science and Technology, China 1988 (Applied
M.Sc. University of Pittsburgh, Pittsburgh, U.S.A 2002 (Information
Ph.D. Medical Univ. of Luebeck, Germany 1996 (Biomedical
Postdoc. Univ. of Pennsylvania, U.S.A 1996-1997 (Tissue Oximetry)
Postdoc. Carnegie Mellon University (CMU), U.S.A. 1997-1999 (Biomedical
I. Izrailtyan, H. Benveniste, “Simultaneous
detection in vivo of changes in cerebral blood volume, oxygenation and
intracellular calcium during cerebral ischemia and reperfusion using
diffuse reflectance and fluorescence.” J. of Cerebral Blood Flow &
Metabolism, in press, (2005).
H. Benveniste, J.S. Fowler, W. Rooney, Y.S.
Ding, A. Baumann, D.H. Moller, C. Du, W. Backus, J. Logan, P. Carter, J.
Copeland, A. Biegon, L. Rosenblum, B. Scharf, S.J. Gatley and N. Volkow;
“Maternal and Fetal [11C] Cocaine Uptake and Kinetics Measured in vivo
by Combined MRI and PET in Pregnant Non-human Primates”; J. Necl. Med,
Y. T. Pan, Q. Wu, Z.G.
Wang, Du C., S. P. R. Brink, "High-Resolution Imaging
Characterization of Bladder Dynamic Morphophysiology with Time-Lapse
Optical Coherence Tomography," Optics Letters, submitted, (2005).
C., Pan Y. T., MacGowan G. A., Koretsky A. P.; " Decreasing motion
artifacts in calcium-dependent fluorescence transients from the perfused
mouse heart using frequency filtering ", Cell Calcium, 35, 141-153,
Y. T. Pan, T. Q. Xie, Du C., S. Bastacky, S. Meyers, M. L. Zeidel,
"Enhancing early bladder cancer detection with fluorescence-guided
endoscopic optical coherence tomography," Optics Letters, 28,
Du C., Pan Y. T., MacGowan G. A., Koretsky A. P.; " Separation of
calcium transients and motion artifact using frequency filtering of
fluorescent signals arising from the perfused mouse heart ",
Proceedings of Society of Optical Engineering (SPIE), in 'Functional
Monitoring and Drug-Tissue Interaction', vol. 4623, 281-286, (2002).
MacGowan G. A., Du C., Koretsky A. P.; "High calcium and
dobutamine positive inotropy in the perfused mouse heart: myofilament
calcium responsiveness, energetic economy, and effects of protein kinase C
inhibition", BMC Physiology, 1:12 (24 Aug.), (2001).
Du C., MacGowan G. A., Farkas D. L., Koretsky A. P.,"Calibration
of calcium dissociation constant of Rhod2 in the perfused mouse heart
using manganese quenching", Cell Calcium, 29(4), 217-227, (2001).
Du C., MacGowan G. A., Farkas D. L., Koretsky A. P., "Calcium
Measurement in perfused mouse heart: Quantitating fluorescence and
absorbance of Rhod-2 by application of photon migration theory,"
Biophy. J., 80, 549-561, January (2001).
MacGowan GA, Du C, Wieczorek DF, Koretsky A. P., "Compensatory
changes in Ca2+ and myocardial O2 consumption in b-tropomyosin transgenic
hearts ", Am J. of Physiol. Heart Cire. Physiol. 281: H2539-H2548,
MacGowan G. A., Du C, Glonty V, Suhan J. P., Farkas D. L., Koretsky A.
P.,"Rhod-2 based measurements of intracellular calcium in the
perfused mouse heart: Cellular and subcellular localization, and response
to positive inotropy", J. Biomedical Optics, 6(1), 23-30, January