Congwu Du
Associate Scientist

Telephone: (631) 344-2965
e-mail: congwu@bnl.gov

Research Interests

Congwu Du is trained as a biomedical engineer with over 10 years in the application of optical spectroscopy for characterization and detection of physiological processes in tissue. Her current projects include the simultaneous detection of the cerebral blood volume and oxygenation as well as intracellular calcium in vivo using visible fluorescence spectroscopy and photon migration techniques. She is the manager of 9.4T MicroMRI facility in Medical Department. Her long-term goal is to combine optical imaging with MRI for the diagnosis of diseases.

Education & Concurrent Positions

B.Sc. Huazhong Univ. of Science and Technology, China, 1985 (Laser Technology)
M.Sc. Huazhong Univ. of Science and Technology, China 1988 (Applied Optics) 
M.Sc. University of Pittsburgh, Pittsburgh, U.S.A 2002 (Information Science) 
Ph.D. Medical Univ. of Luebeck, Germany 1996 (Biomedical Engineering) 
Postdoc. Univ. of Pennsylvania, U.S.A 1996-1997 (Tissue Oximetry) 
Postdoc. Carnegie Mellon University (CMU), U.S.A. 1997-1999 (Biomedical Imaging)

Selected Publications:

I. Izrailtyan, H. Benveniste, “Simultaneous detection in vivo of changes in cerebral blood volume, oxygenation and intracellular calcium during cerebral ischemia and reperfusion using diffuse reflectance and fluorescence.” J. of Cerebral Blood Flow & Metabolism, in press, (2005).

H. Benveniste, J.S. Fowler, W. Rooney, Y.S. Ding, A. Baumann, D.H. Moller, C. Du, W. Backus, J. Logan, P. Carter, J. Copeland, A. Biegon, L. Rosenblum, B. Scharf, S.J. Gatley and N. Volkow; “Maternal and Fetal [11C] Cocaine Uptake and Kinetics Measured in vivo by Combined MRI and PET in Pregnant Non-human Primates”; J. Necl. Med, 46:312-320, (2005).

Y. T. Pan, Q. Wu, Z.G. Wang, Du C., S. P. R. Brink, "High-Resolution Imaging Characterization of Bladder Dynamic Morphophysiology with Time-Lapse Optical Coherence Tomography," Optics Letters, submitted, (2005).

Du C., Pan Y. T., MacGowan G. A., Koretsky A. P.; " Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filtering ", Cell Calcium, 35, 141-153, (2004).

Y. T. Pan, T. Q. Xie, Du C., S. Bastacky, S. Meyers, M. L. Zeidel, "Enhancing early bladder cancer detection with fluorescence-guided endoscopic optical coherence tomography," Optics Letters, 28, 2485-87, (2003)

Du C., Pan Y. T., MacGowan G. A., Koretsky A. P.; " Separation of calcium transients and motion artifact using frequency filtering of fluorescent signals arising from the perfused mouse heart ", Proceedings of Society of Optical Engineering (SPIE), in 'Functional Monitoring and Drug-Tissue Interaction', vol. 4623, 281-286, (2002).

MacGowan G. A., Du C., Koretsky A. P.; "High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition", BMC Physiology, 1:12 (24 Aug.), (2001).

Du C., MacGowan G. A., Farkas D. L., Koretsky A. P.,"Calibration of calcium dissociation constant of Rhod2 in the perfused mouse heart using manganese quenching", Cell Calcium, 29(4), 217-227, (2001).

Du C., MacGowan G. A., Farkas D. L., Koretsky A. P., "Calcium Measurement in perfused mouse heart: Quantitating fluorescence and absorbance of Rhod-2 by application of photon migration theory," Biophy. J., 80, 549-561, January (2001).

MacGowan GA, Du C, Wieczorek DF, Koretsky A. P., "Compensatory changes in Ca2+ and myocardial O2 consumption in b-tropomyosin transgenic hearts ", Am J. of Physiol. Heart Cire. Physiol. 281: H2539-H2548, (2001).

MacGowan G. A., Du C, Glonty V, Suhan J. P., Farkas D. L., Koretsky A. P.,"Rhod-2 based measurements of intracellular calcium in the perfused mouse heart: Cellular and subcellular localization, and response to positive inotropy", J. Biomedical Optics, 6(1), 23-30, January (2001).