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Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490

Richard Ferrieri

Scientist


Telephone:  (631) 344-4947
Fax: (631) 344-5815
e-mail: rferrieri@bnl.gov

See also:
Radiotracer Chemistry and Neuroimaging
Plant Imaging

Research Interests

    Dr. Ferrieri is a radiochemist whose research is focused on developing new technology using radiotracers to interrogate induced sink strength in plants at metabolic and whole-plant levels. Fundamental research geared to understanding how plant metabolism is regulated across scales from cellular biochemistry to whole-plant physiology is key to DOE’s success in areas such as improved carbon sequestration by plants, and improved plant feedstock for biofuel. Dr. Ferrieri uses short-lived radiotracers such as 13N (t1/2 ,10 m), 11C (t1/2, 20 m) to insert radioactive probes into various parts of a plant’s metabolic machinery, and using a combination of in vivo imaging techniques and nuclear counting techniques, he measures changes in metabolic fluxes that can give rise to changes in resource allocation at the whole-plant level. His recent focus here is to understand the timing by which metabolic control and gene regulation coordinate with the modification of cell walls—a major metabolic sink in plants. His interests also center on developing new imaging biomarkers that are suitable for quantifying changes in lignocellulosic properties of cell walls, as well as aid in the multi-modality imaging of dynamic processes.

 Education & Concurrent Positions

  • B.S. Fairfield University, 1975
  • Technical Collaborator, Brookhaven National Laboratory, 1978-1979
  • Ph.D. Texas A&M University, 1979
  • Research Associate, BNL, 1979-1981
  • Assistant Chemist, BNL, 1981-1983
  • Associate Chemist, BNL, 1983-1986
  • Visiting Scientist UC Berkeley, 1986-1987
  • Chemist, BNL, 1986-present

Selected Publications

    Hanik N., Gomez S., Schueller M., Orians C.M. and Ferrieri R.A.
    Metabolic Flux Analysis using 13N and 11C in Nicotana attenuata reveals new insights into the timeline by which methyl jasmonate reconfigures primary metabolism.
    The Plant Journal (manuscript in preparation).

    Ferrieri R.A. and Schueller M.
    Imaging regional glucose utilization using 18FDG after modification of cell-wall construction.
    Plant, Cell & Environment (manuscript in preparation).

    Babst B.A., Ferrieri R.A., Thorpe M.R. and Orians C.M.
    Lymantria dispar herbivory induces rapid changes in carbon transport and partitioning in Populus.
    Entomologia Experimentalis et Applicata (in press)(2008) .

    Thorpe M.R., Ferrieri A.P., Herth M.M. and Ferrieri R.A.
    11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled.
    Planta, 226(2): 541-551 (2007). PubMed

    Babst B., Ferrieri R.A., Gray D.W., Thorpe M.R., Lerdau M., Schlyer D., Schueller M., Thorpe M. and Orians C.M.
    Jasmonic acid induces rapid changes in carbon transport and partitioning in Populus.
    New Phytologist, 167(1):63-72 (2005). PubMed

    Ferrieri R.A., Gray D.W., Babst B.A., Schueller M.J., Schlyer D.J., Thorpe M.R., Orians C.M. and Lerdau M.
    Use of carbon-11 shows that exogenous jasmonic acid influences carbon sources for isoprene biosynthesis in Populus.
    Plant Cell & Environment, 28:591-602 (2005) .

    Herth M.M., Thorpe M.R. and Ferrieri R.A.
    Synthesis of the phytohormone [11C]methyl jasmonate via methylation on a C18Sep PakTM cartridge.
    Journal of Labelled Compounds and Radiopharmaceuticals, 48(5):379-386 (2005).

    Ferrieri A.P., Thorpe M.R. and Ferrieri R.A.
    Up-regulating plant defenses in Populus increases phytoremediation capacity for carbon tetrachloride.
    8th International Symposium on Remediation, June (2005), Batelle Press.

    Gerasimov M.R., Ferrieri R.A., Pareto D., Logan D., Alexoff D. and Ding Y-S
    Synthesis and evaluation of inhaled [11C]butane and intravenously injected [11C]acetone as potential radiotracers for studying inhalant abuse.
    Nucl. Med. Biology, 32:201-208 (2005). PubMed

    Pritchard J., Tomos D., Farrar J.F., Minchin P.E.H., Gould N., MacRae E.A., Paul M.J., Ferrieri R.A., Gray D.W. and Thorpe M.R.
    Turgor, solute import and growth in maize roots treated with galactose.
    Functional Plant Biology, 31:1095 (2004).

    Fowler J.S., Logan J., Wang G-J, Volkow N.D., Telang F., Ding Y-S, Shea C., Garza V., Xu Y., Li Z., Alexoff D., Vaska P., Ferrieri R., Schlyer D.J., Zhu W. and Gatley S.J.
    Comparison of the Binding of the Irreversible Monoamine Oxidase Tracers, [11C]Clorgyline and [11C]L-Deprenyl in Brain and Peripheral Organs in Humans
    Nucl. Med. Biol., 31(3):313-319 (2004). PubMed

    Ferrieri R.A.
    Production and Applications of Synthetic Precursors Labeled with Carbon-11 and Fluorine-18, In Handbook of Radiopharmaceuticals: Radiochemistry and Applications.
    John Wiley & Sons, Ltd.: United Kingdom, 229-282 (2003).

    Ferrieri R.A.
    Supercritical Fluids in Medical Radioisotope Processing and Chemistry, Part 1: Technology, Instrumentation and Methodology.
    J. Labeled Cmpd. Radiopharm., 46:893-922 (2003).

    Ferrieri R.A.
    Supercritical Fluids in Medical Radioisotope Processing and Chemistry, Part 2: Applications-Real and Demonstrated.
    J. Labeled Cmpd. Radiopharm, 46:923-943 (2003).

    Gerasimov M.R., Ferrieri R.A., Schiffer W.K., Logan J., Gatley S.J., Gifford A.N., Alexoff D.A., Marsteller D.A., Shea C., Garza V., Carter P., King P., Ashby C.R., Vitkun S. and Dewey S.L.
    Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice.
    Life Sci., 70(23):2811-2828 (2002). PubMed

    Gerasimov M.R., Schiffer W.K., Marstellar D.A., Ferrieri R., Alexoff D. and Dewey S.L.
    Toluene inhalation produces regionally specific changes in extracellular dopamine.
    Drug Alcohol Depend, 65(3):243-51 (2002). PubMed

    Gerasimov M.R., Logan J., Ferrieri R.A., Muller R.D., Alexoff D. and Dewey S.L.
    Effect of vehicle on brain uptake of [11C]toluene.
    Nucl. Med. Biol., 29(5):607-12 (2002). PubMed

    Muller R.D., Ferrieri R.A., Gerasimov M.R. and Garza V.
    Supercritical CO2 fluid radiochromatography system used to purify [11C]toluene for PET.
    Nucl. Med. Biol., 29:351-357 (2002). PubMed

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Last Modified: April 25, 2008
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DOE, Office of ScienceOne of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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