Joanna Fowler Senior Scientist Telephone: (631) 344-4365 Fax:  (631) 344-7902 e-mail: fowler@bnl.gov See Also: Radiotracer Chemistry and Neuroimaging Recent Awards: National Medal of Science National Academy of Sciences Award in Chemical Sciences

Research Interests

• Organic synthesis and neurochemistry; radiotracer synthesis with positron emitters; mechanistic studies relating to the development of radiotracers for positron emission tomography (PET); translational applications of radiotracers to problems in neuroscience; PET studies of neurotransmitter activity, enzyme activity and drug mechanisms.

 Education & Concurrent Positions

• B.A. University of South Florida, 1964; Ph.D. University of Colorado, 1967
• Senior Research Associate, University of East Anglia, Norwich, England, 1968
• Research Associate, Medical Department, Brookhaven National Laboratory, 1969-1971
• Associate Chemist, Medical Department, BNL, 1971-1974
• Scientist, continuing, Medical Department, BNL, 1974-1976
• Chemist, Chemistry Department, BNL, 1976-1983
• Chemist, with tenure, BNL,1983-1988
• Senior Chemist, BNL, 1988-present

Selected Publications

• Hooker J.M., Reibel A.T., Hill S.M., Schueller M.J., and Fowler J.S.
  One-pot, direct incorporation of [11C]CO2 into carbamates.
  Angew Chem Int Ed Engl., 48(19):3482-3485 (2009).  PubMed
• Kil K.E., Biegon A., Ding Y.-S., Fischer A., Ferrieri R.A., Kim S.W., Pareto D., Schueller M.J., and Fowler J.S.
  Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug.
  Nucl Med Biol., 36(2):215-223 (2009).  PubMed
• Reid A.E, Hooker J., Shumay E., Logan J., Shea C., Kim S.W., Collins S., Xu Y., Volkow N.D., and Fowler J.S.
  Evaluation of 6-([18F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain.
  Nuclear Medicine and Biology 36(3):247-258 (2009).
• Volkow N.D., Fowler J.S., Logan J., Alexoff D., Zhu W., Telang F., Wang G.-J., Jayne M., Hooker J.M., Wong C., Hubbard B., Carter P., Warner D., King P., Shea C., Xu Y., Muench L., and Apelskog-Torres K.
  Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.
  JAMA, 301(11):1148-1154 (2009).  PubMed
• Alia-Klein N., Kriplani A., Pradhan K., Ma Y., Logan J. , Williams B., Craig I.W., Telang F., Tomasi D., Goldstein R.Z., Wang G.-J., Volkow N.D., and Fowler J.S.
  The MAO-A genotype does not modulate resting brain metabolism in adults.
  Psychiatry Research, 164(1):73-76 (2008).
• Fowler J., Volkow N.D., Logan J., Alexoff D., Telang F., Wang G-J., Wong C., Ma Y., Kriplani A., Pradhan K., Schlyer D., Jayne M., Hubbard B., Carter P., Warner D., King P., Shea C., Xu Y., Muench L., and Apelskog K.
  Fast uptake and long-lasting binding of methamphetamine in the human brain: Comparison with cocaine.
  NeuroImage, 43(4):756-763 (2008).  PubMed
• Hooker J.M., Schönberger M., Schieferstein H., and Fowler J.S.
  A simple, rapid method for the preparation of [11C]formaldehyde.
  Angew Chem Int Ed Engl., 47(32):5989-5992 (2008).
• Reid A., Ding Y.-S., Eckelman W.C., Logan J., Alexoff D., Shea C., Xu Y., and Fowler J.S.
  Comparison of the pharmacokinetics of different analogs of 11C-labled TZTP for imaging muscarinic M2 receptors with PET.
  Nuclear Medicine and Biology, 35:287-298 (2008).
• Alia-Klein N., Goldstein R.Z., Kriplani A., Logan J., Tomasi D., Williams B., Telang F., Shumay E., Biegon A., Craig I.W., Henn F., Wang G.-J., Volkow N.D., and Fowler J.S.
  Brain monoamine oxidase A activity predicts train aggression.
  Journal of Neuroscience, 28(19):5099-5104 (2008).
• Baler R.D., Volkow N.D., Fowler J.S. and Benveniste H.
  Is fetal brain monoamine oxidase inhibition the missing link between maternal smoking and conduct disorders?
  Journal of Psychiatry Neuroscience, 33:187-195 (2008).  PubMed
• Fowler J.S., Alia-Klein N., Kriplani A., Logan J., Williams B., Zhu W., Craig I.W., Telang F., Goldstein R., Volkow N.D., Vaska P. and Wang G.J.
  Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.
  Biol. Psychiatry, 62(4):355-358 (2007).  PubMed
• Fowler J.S., Kroll C., Ferrieri R., Alexoff D., Logan J., Dewey S.L., Schiffer W., Schlyer D., Carter P., King P., Shea C., Xu Y., Muench L., Benveniste H., Vaska P. and Volkow N.D.
  PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.
  J. Nucl. Med., 48(10):1724-1732 (2007).  PubMed
• Fowler J .S., Logan J., Wang G.-J., Volkow N.D., Telang F., Zhu W., Franceschi D., Shea C., Garza V., Xu Y., Ding Y.S., Alexoff D., Warner D., Netusil N., Carter P., Jayne M., King P. and Vaska P.
  Comparison of Monoamine Oxidase A In Peripheral Organs In Nonsmokers and Smokers.
  J. Nucl. Med.,  46(9):1414-1420 (2005).  PubMed
• Fowler J.S., Logan J., Wang G.-J., Volkow N.D., Telang F., Zhu W., Franceschi D., Pappas N., Ferrieri R., Shea C., Garza V., Xu Y., Schlyer D., GatleyS.J., Ding Y.-S., Alexoff A., Warner D., Netusil N., Carter P., Jayne M., King P. and Vaska P.
  Low monoamine oxidase B in peripheral organs in smokers.
  Proc. Natl. Acad. Sci., 100(20):11600-11605 (2003).  PubMed
• Fowler S., Wang G.-J., Volkow N.D., Franceschi D., Logan J., Pappas N., Shea C., MacGregor R. and Garza V.
  Maintenance of Brain MAO B Inhibition in Smokers after a 12-hour Cigarette Abstinence.
  J. Am. J. Psychiatry, 157(11):1864-1866 (2000).  PubMed
• Fowler J.S., Volkow N.D., Wang G.J., Ding Y.S. and Dewey S.L.
  PET and Drug Research and Development.
  J. Nucl. Med., 40(7):1154-1163 (1999).  PubMed
• Fowler J.S. and Wolf A.P.
  Working Against Time: Rapid Radiotracer Synthesis and Imaging the Human Brain.
  Accts. Chem. Res., 30:181-188 (1997).
• Fowler J.S., Volkow N.D., Wang G.-J., Pappas N., Logan J., MacGregor R., Alexoff D., Shea C., Wolf A.P., Warner D., Zezulkova I. and Cilento R.
  Inhibition of Monoamine Oxidase B in the Brains of Smokers.
  Nature, 379(6567):733-736 (1996).  PubMed
• Fowler J.S., Volkow N.D., Wang G.-J., Pappas N., Logan J., Shea C., Alexoff D.L., MacGregor R.R., Schyler D.J., Wolf A.P. and Zelzukova I.
  Brain Monoamine Oxidase A Inhibition in Cigarette Smokers.
  Proc. Natl. Acad. Sci. USA, 93(24):14065-14069 (1996).  PubMed
• Fowler J.S., Wang G.-J., Logan J., Xie S., Volkow N.D., MacGregor R.R., Schlyer D.J., Pappas N., Alexoff D.L., Patlak C. and Wolf A.P.
  Selective Reduction of Radiotracer Trapping by Deuterium Substitution: Comparison of [ 11 C]L-Deprenyl and [ 11 C]L-Deprenyl-D2 for MAO B Mapping.
  J. Nucl. Med., 36(7): 1255-1262 (1995).  PubMed

Last Modified: September 18, 2009
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