Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490
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Michiko Miura
Scientist
Telephone: (631) 344-3618
e-mail:
miura@bnl.gov
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Research Interests
- Synthesis of porphyrins (containing boron and boron-free) and boron-containing small molecules.
- Study of the biological properties of compounds as radiosensitizers for X-ray radiation therapy [XRT]
and boron neutron-capture therapy [BNCT].
- Study of microbeam radiosurgery [MBRS].
- We are primarily interested in developing new radiosensitizers for XRT and boron-carriers
for BNCT. Various compounds, carboranyl porphyrins, in particular, are synthesized and then
tested in tumor-bearing rodents to assess critical biological properties: Biodistribution,
toxicity, and therapeutic efficacy. A couple of lead porphyrins have shown significant improvements
in biodistribution with low toxicity. Tumor ablation has also been demonstrated in vivo using
XRT or BNCT with low normal tissue damage. In addition, all new compounds have the potential
to be imaged by PET, SPECT, and in some cases MRI. Research is also being carried out on new
formulations of the lipophilic porphyrins and on the testing of chemotherapeutic agents in
animal tumor models.
Education & Concurrent Positions
- B.S. University of California, Riverside, 1978
- Ph.D. University of California, Davis, 1984
- Postdoctoral Fellow, Stanford Research Institute, 1984-1986
- Research Associate, Medical Department, BNL, 1987-1990
- Chemist Associate II, Department of Applied Sciences, BNL, 1991-1993
- Assistant Scientist, Medical Department, BNL, 1994-1996
- Associate Chemist, BNL, 1996-1999
- Scientist, BNL, 1999-present
Selected Publications
- M. Miura, H. Blattman, E. Brauer-Krisch, A. Bravin, A.L. Hanson, M.M. Nawrocky,
Micca P.M., D.N. Slatkin, and J.A. Laissue Radiosurgical palliation of aggressive
murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams.
Br. J. Rad. 2006; 79(937):71-75.
PubMed
- Renner M.W., Miura M., Easson M.W. and Vicente M.G.H. Recent progress in the
syntheses and biological evaluation of boronated porphyrins for boron neutron-capture
therapy. Anticancer Agents Med Chem. 2006; 6(2):145-157.
PubMed
- Wu H., Micca P.L., Makar M.S., and Miura M. Total syntheses of three copper(II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological
properties in EMT-6 tumor-bearing mice. Bioorg Med. Chem. 2006; 14(15):5083-5092.
PubMed
- Miura M. , Morris G.M., Micca P.L., Nawrocky M.M., Makar M.S., Cook S.P.,
and Slatkin D.N. Copper octabromotetracarboranylphenylporphyrin: Synthesis and
its toxicity, and biodistribution in tumour-bearing mice. Br. J. Rad. 2004; 77(919):573-580.
PubMed
- Kreimann E.L., Miura M., Itoiz M.E., Heber E., Garavaglia R.N., Batistoni D.,
Rebagliati R.J., Roberti M.J., Micca P.L., Coderre J.A. and Schwint A.E. Biodistribution
of a carborane-containing porphyrin as a targeting agent for Boron Neutron Capture Therapy of
oral cancer in the hamster cheek pouch. Arch. Oral Biol, 2003; 48:223-232.
- Miura M., Morris G.M., Micca P.L., Lombardo D.T., Youngs K.M., Kalef-Ezra J.A.,
Hoch D.A., Slatkin D.N., Ma R. and Coderre J.A. Boron neutron-capture therapy of a murine
mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin.
Radiat. Res., 2001;155(4):603-610.
PubMed
- Miura M., Micca P.L., Fischer C.D., Gordon C.R., Heinrichs J.C. and Slatkin D.N.
Evaluation of carborane-containing porphyrins as a tumor-targeting agents for
boron neutron-capture therapy. Br. J. Radiol., 1998; 71(847):773-781.
PubMed
Last Modified: March 7, 2008
Please forward all questions about this site to:
Denise Monteleone
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