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| Figure 2: Increased survival in mice exposed to lethal doses of gamma-radiation and given single-dose treatment with bFGF or synthetic FGF analogs. Unlike other radioprotectants which must be administered prior to irradiation, the time window for cytokine-mediated radioprotection extends several hours after irradiation. Unlike natural or recombinant protein cytokines / growth factors, synthetic FGF analogs survive the GI tract and can be administered orally. |