Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490

 

Frank Telang

Scientist


Telephone:  (631) 344-3169
e-mail: ftelang@bnl.gov

Research Interests

  • Application of PET and MRI techniques to brain disorders.
  • Brain Imaging Group, Utilizing PET, 4T MRI.
  • Clinical PET studies in Addiction, Dementias.
  • fMRI and MRS in Alcohol/Cocaine addiction, Basic Neuroscience, Brain Tumor Research.
  • Quantitative T1/Relaxographic MRI/MRS in Multiple Sclerosis.

 Education & Concurrent Positions

  • B.S., Univ. of Michigan, Ann Arbor, 1973-1977.
  • Graduate Studies, Neuroscience, Michigan State Univ., 1980-1981.
  • Univ. of Arizona, Dept. of Neurosurgery, Research asst., (Epilepsy), 1981-1982.
  • M.D., Doctor of Medicine, Northeast Ohio Univ. College of Medicine, 1982-1986.
  • Internship, Internal Medicine, Henry Ford Hospital, Detroit, Michigan, 1986-1987.
  • Residency, Neurology, Univ. of Pittsburgh,1987-1990.
  • Chief Resident, Neurology, Univ. of Louisville, 1991-1990.
  • Fellow in Neuroimaging, 4T MRI, PET and SPECT,(NIAAA sponsored) in Dept. of Psychiatry, SUNY-SB and BNL, 1997-2000.
  • Assoc. Scientist, Medical Dept. BNL, 2000-2003.
  • Neurologist/Staff Clinician, Intramural Program, National Institute of Health, (NIH/NIAAA), 2003-present.

Selected Publications

  • Alia-Klein N., Goldstein R.Z., Tomasi D., Zhang L., Fagin-Jones S., Telang F., Wang G.J., Fowler J.S. and Volkow N.D. What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex. Emotion, 2007; 7(4):735.
  • PubMed
  • Fowler J.S., Alia-Klein N., Kriplani A., Logan J., Williams B., Zhu W., Craig I.W., Telang F., Goldstein R., Volkow N.D., Vaska P. and Wang G.J.  Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biol Psychiatry, 2007; 62(4):355-8. Epub 2006 Dec 4.
  • PubMed
  • Goldstein R.Z., Alia-Klein N., Tomasi D., Zhang L., Cottone L.A., Maloney T., Telang F., Caparelli E.C., Chang L., Ernst T., Samaras D., Squires N.K. and Volkow N.D.  Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction? Am J Psychiatry, 2007; 164(1):43-51.
  • PubMed
  • Goldstein R.Z., Tomasi D., Alia-Klein N., Cottone L.A., Zhang L., Telang F. and Volkow N.D.  Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers. Drug Alcohol Depend., 2007; 87(2-3):233-40. Epub 2006 Sep 25.
  • PubMed
  • Goldstein R.Z., Tomasi D., Alia-Klein N., Zhang L., Telang F. and Volkow N.D.  The effect of practice on a sustained attention task in cocaine abusers. Neuroimage, 2007; 35(1):194-206. Epub 2007 Jan 22.
  • PubMed
  • Goldstein R.Z., Tomasi D., Rajaram S., Cottone L.A., Zhang L., Maloney T., Telang F., Alia-Klein N. and Volkow N.D.  Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience, 2007; 144(4):1153-9. Epub 2006 Dec 29.
  • PubMed
  • Logan J., Wang G.J., Telang F., Fowler J.S., Alexoff D., Zabroski J., Jayne M., Hubbard B., King P., Carter P., Shea C., Xu Y., Muench L., Schlyer D., Learned-Coughlin S., Cosson V., Volkow N.D. and Ding Y.S.  Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress. Nucl Med Biol., 2007; 34(6):667-679. Epub 2007 Jun 8.
  • PubMed
  • Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C. and Volkow N.D.  Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception. Psychiatry Res., 2007; 155(3):189-201. Epub 2007 Jun 19.
  • PubMed
  • Tomasi D., Goldstein R.Z., Telang F., Maloney T., Alia-Klein N., Caparelli E.C. and Volkow N.D.  Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence. Brain Res., 2007; 1171:83-92. Epub 2007 Aug 10.
  • PubMed
  • Volkow N.D., Fowler J.S., Wang G.J., Swanson J.M. and Telang F.  Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Arch Neurol., 2007; 64(11):1575-1579.
  • PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Telang F., Jayne M. and Wong C.  Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission. Am J Psychiatry., 2007; 164(1):157-160.
  • PubMed
  • Volkow N.D., Wang G.J., Newcorn J., Fowler J.S., Telang F., Solanto M.V., Logan J., Wong C., Ma Y., Swanson J.M., Schulz K. and Pradhan K.  Brain dopamine transporter levels in treatment and drug naive adults with ADHD. Neuroimage, 2007; 34(3):1182-1190.
  • PubMed
  • Volkow N.D., Wang G.J., Newcorn J., Telang F., Solanto M.V., Fowler J.S., Logan J., Ma Y., Schulz K., Pradhan K., Wong C. and Swanson J.M.  Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry., 2007; 64(8):932-940.
  • PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Logan J., Jayne M., Ma Y., Pradhan K. and Wong C.  Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci., 2007; 27(46):12700-12706.
  • PubMed
  • Tomasi D., Chang L., de Castro Caparelli E., Telang F. and Ernst T.  The human immunodeficiency virus reduces network capacity: acoustic noise effect. Ann Neurol., 2006; 59(2):419-423
  • PubMed
  • Volkow N.D., Wang G.J., Begleiter H., Porjesz B., Fowler J.S., Telang F., Wong C., Ma Y., Logan J., Goldstein R., Alexoff D. and Thanos P.K.  High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors. Arch Gen Psychiatry, 2006; 63(9):999-1008.
  • PubMed
  • Volkow N.D., Wang G.J., Ma Y., Fowler J.S., Wong C., Jayne M., Telang F. and Swanson J.M.  Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. Neuroimage, 2006; 32(4):1782-1792. Epub 2006 Jun 6.
  • PubMed
  • Volkow N.D., Wang G.J., Telang F., Fowler J.S., Logan J., Childress A.R., Jayne M., Ma Y. and Wong C.  Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci., 2006; 26(24):6583-6538. Erratum in: J Neurosci. 2006 Jul 5;26(27).
  • PubMed
  • Wang G.J., Yang J., Volkow N.D., Telang F., Ma Y., Zhu W., Wong C.T., Tomasi D., Thanos P.K. and Fowler J.S. Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry. Proc Natl Acad Sci U S A., 2006; 103(42):15641-15645. Epub 2006 Oct 5.
  • PubMed
  • Fowler J.S., Logan J., Wang G.J., Volkow N.D., Telang F., Zhu W., Franceschi D., Shea C., Garza V., Xu Y., Ding Y.S., Alexoff D., Warner D., Netusil N., Carter P., Jayne M., King P. and Vaska P.  Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers. J Nucl Med., 2005; 46(9):1414-1420.
  • PubMed
  • Ding Y.S., Fowler J.S., Logan J., Wang G.J., Telang F., Garza V., Biegon A., Pareto D., Rooney W., Shea C., Alexoff D., Volkow N.D. and Vocci F.  6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter. Synapse., 2004; 53(3):184-189.
  • PubMed
  • Fowler J.S., Logan J., Wang G.J., Volkow N.D., Telang F., Ding Y.S., Shea C., Garza V., Xu Y., Li Z., Alexoff D., Vaska P., Ferrieri R., Schlyer D., Zhu W. and Gatley J.S.  Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans. Nucl Med Biol., 2004; 31(3):313-319.
  • PubMed
  • Volkow N.D., Wang G.J., Fowler J.S., Telang F., Maynard L., Logan J., Gatley S.J., Pappas N., Wong C., Vaska P., Zhu W., Swanson J.M.  Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatry. 2004 Jul;161(7):1173-1780.
  • PubMed
  • Wang G.J., Chang L., Volkow N.D., Telang F., Logan J., Ernst T., Fowler J.S.  Decreased brain dopaminergic transporters in HIV-associated dementia patients. Brain. 2004; 127(Pt 11):2452-2458. Epub 2004 Aug 19.
  • PubMed
  • Wang G.J., Volkow N.D., Telang F., Jayne M., Ma J., Rao M., Zhu W., Wong C.T., Pappas N.R., Geliebter A., Fowler J.S., Wang G.J., Volkow N.D., Telang F., Jayne M., Ma J., Rao M., Zhu W., Wong C.T., Pappas N.R., Geliebter A. and Fowler J.S.  Exposure to appetitive food stimuli markedly activates the human brain. Neuroimage, 2004; 21(4):1790-1797.
  • PubMed
  • Volkow N.D., Wang G.J., Ma Y., Fowler J.S., Zhu W., Maynard L., Telang F., Vaska P., Ding Y.S., Wong C.and Swanson J.M.  Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. J. Neurosci., 2003; 23(36):11461-11468
  • PubMed
  • Pan J.W., Telang F.W., Lee J.H., de Graaf R.A., Rothman D.L., Stein D.T. and Hetherington H.P.   Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J Neurochem, 2001; 79(3):539-544.
  • PubMed
  • de Graaf R.A., Pan J.W., Telang F., Lee J.H., Brown P., Novotny E.J., Hetherington H.P. and Rothman D.L. Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab., 2001; 21(5):483-492.
  • PubMed
  • Landis C.S., Li X., Telang F.W., Coderre J.A., Micca P.L., Rooney W.D., Latour L.L., Vetek G., Palyka I. and Springer C.S. Jr.  Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. Magn Reson Med. 2000; 44(4):563-74.
  • PubMed
  • Orion I., Rosenfeld A.B., Dilmanian F.A., Telang F., Ren B. and Namito Y.  Monte Carlo simulation of dose distributions from a synchrotron-produced microplanar beam array using the EGS4 code system. Phys Med Biol., 2000; 45(9):2497-2508.
  • PubMed
  • Pan J.W., Stein D.T., Telang F., Lee J.H., Shen J., Brown P., Cline G., Mason G.F., Shulman G.I., Rothman D.L. and Hetherington H.P.  Spectroscopic imaging of glutamate C4 turnover in human brain. Magn Reson Med., 2000; 44(5):673-679.
  • PubMed
  • Sammi M.K., Pan J.W., Telang F.W., Schulein D., Molina P.E., Volkow N.D., Springer C.S. and Hetherington H.P. Measurement of Human Brain Ethanol T(2) by Spectroscopic Imaging at 4T. Magn Reson Med, 2000; 44(1):35-40.
  • PubMed
  • Hetherington H.P., Pan J.W. , Telang F., Pappas N. and Volkow N.D.   Reduced Brain GABA Levels in Cocaine Abusers, abstract submitted 11/99.
  • Hetherington H.P., Telang F., Pan J.W., Sammi M., Schuhlein D., Molina P, and Volkow N.D.  Spectroscopic imaging of the uptake kinetics of human brain ethanol. Magn Reson Med, 1999; 42(6):1019-1026.
  • PubMed
  • Telang F.W., Ding Yu-Shin, Volkow, N. D., Molina P.E. and Gatley S.J.  Failure of [11C]-Pyridostigmine To Cross Blood Brain Barrier in Stressed Mice. Nuclear Medicine and Biology, 1999; 26(2):249-250.
  • Telang F.W., Volkow N.D., Logan J., Fowler J.S., Felder C., Levy A., Wong C. and Wang G.-J.   Distribution of Cocaine in the Human Brain as Assessed with Averaged [11-C] Cocaine Images. Synapse, 1999; 31(4):290-296.
  • PubMed
  • Landis C.S., Li X., Telang F.W., Molina P.E., Palyka I., Vetek G. and Springer C.S.   Equilibrium Transcytolemmal Water Exchange in Skeletal Muscle in Vivo. Magn Reson Med, 1999; 42(3):467-478.
  • PubMed

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Last Modified: March 7, 2008
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