Milestones
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Stimulant mechanisms (Volkow and Fowler et al., 2009):
Using a multi-tracer approach we showed that the drug modafinil which is increasingly used off label to enhance cognition, unexpectedly increases brain dopamine creating the need for heightened awareness of its abuse potential in vulnerable populations.
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Gender and cognitive control of desire for food (Wang et al., 2009):
Using PET and 18FDG to examine the brain circuits involved in voluntary inhibition of hunger during food stimulation revealed that in men, but not in women which may be contributing factor to gender differences in obesity.
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Triazole alkylation (Kim et al., 2009):
By coupling rapid radiotracer synthesis with advanced purification and analytical methods, we synthesized [11C]vorozole leading to the first pure radiotracer for aromatase, a key enzyme in estrogen biosynthesis with potential applications in health and in plant science.
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Carbon-11 chemistry (Hooker et al., 2008):
Using a new approach to carbon-11 chemistry, we discovered a novel, rapid synthesis of C-11 formaldehyde, an important one-carbon precursor for new radiotracers for molecular imaging in biological systems.
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New PET detection approaches (Vaska et al., 2008):
A cadmium zinc telluride PET system has been completed with a resolution among the highest ever reported in a full-ring scanner, and we have demonstrated the feasibility of a novel approach to PET detection using a monolithic scintillator and avalanche photodiodes
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Plant protective mechanisms (Babst et al., 2008):
By pulse labeling plants (Poplar) with 11CO2, we have learned that jasmonic acid increases the supply of photosynthate to roots suggesting that this may be a mechanism to increase plant tolerance to herbivory.
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Awake [11C]raclopride methology (Patel et al., 2008):
Using a novel paradigm, we performed the first quantitative [11C]raclopride studies in awake animals using microPET showing major differences in radiotracer uptake between awake and anesthetized state.
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Simultaneous PET-MRI (Schlyer et al., 2007):
The powerful technique of simultaneous PET and MRI imaging has been accomplished by focusing on the reduction of cross-talk between the 2 modalities.
Last Modified: May 20, 2009
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Denise Monteleone
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One of ten national laboratories overseen and primarily
funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven
National Laboratory conducts research in the physical, biomedical, and environmental
sciences, as well as in energy technologies and national security. Brookhaven Lab also
builds and operates major scientific facilities available to university, industry and
government researchers. Brookhaven is operated and managed for DOE's Office of Science by
Brookhaven Science Associates, a limited-liability company founded by Stony Brook University,
the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science
and technology organization.