Radiotracer chemistry is focused on the short lived positron emitters. New radiotracer chemistry and molecular targeting strategies are being developed to increase the complexity and diversity of molecular probes (small molecules and plant hormones) for imaging applications. We emphasize C-11 chemistry because the substitution of stable carbon with carbon-11 provides the opportunity to measure and quantify the distribution and kinetics of physiologically relevant substrates and signaling molecules without altering the biological properties of the parent molecule. Recent accomplishments include the development of miniaturized automated systems for the production of C-11 precursor molecules, the synthesis of C-11 labeled azaleic acid and the radiolabeling of auxin for studies of their movement and metabolism in the whole plant in vivo.
Last Modified: September 5, 2012