Transcranial Magnetic Stimulation: Functional Magnetic Resonance Imaging

The most promising yet the most challenging tool for neuroimaging research is the simultaneous combination of TMS-fMRI. Using them together we can excite a specific brain region, its directly associated network during the response can be assessed in parallel with high spatial - and temporal - resolution, thus allowing us to manipulate brain activity as an independent variable, in a noninvasive, non-painful, and safe way, in living humans [1, 2].

We have started to explore this novel multimodality combination in our state-of-the-art 4 T MRI scanner and to apply this new combinational neuroimaging tool to map the functional networks associated with the applied localized stimuli on the cortex.

1. Sack A T and Linden D E, Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: possibilities and limitations. Brain Res Brain Res Rev, 2003. 43: 41-56.
2. Caparelli E C, TMS&fMRI - A new neuroimaging combinational tool to study brain function. CMIR, 2007. 3: 109-15.

Last Modified: February 1, 2008
Please forward all questions about this site to: Elisabeth Caparelli

One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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