Andrew Gifford Scientist Telephone:  (631) 344-7069 e-mail: gifforda@bnl.gov

Research Interests

• Radiochemical labeling of biomolecules, especially with radiohalogens and radiolabeled prosthetic groups
• Investigating new approaches to improving and simplifying radionuclide labeling of organic molecules, e.g. by developing new solid phase reagents for radiolabeling biomolecules. The solid phase approach is expected to be compatible with kit development and automated synthesis methods.
• Autoradiographic imaging, including a project to image RNA expression in Arabidopsis plants using radiolabeled aptamer ligands.
• Radioligand binding assays and in vivo PET receptor occupancy studies.

 Education & Concurrent Positions

• B.S. University of London, 1985; Ph.D. University of St. Andrews, Scotland, 1989
• Post-Doctoral Fellow, University of Texas Medical Branch, 1990-1994
• Assistant Scientist, Medical Department, BNL, 1995-1997
• Associate Scientist, BNL 97-99, Scientist, 1999-present
• Faculty Member, Graduate Program in Neurobiology and Behavior, S.U.N.Y. at Stony Brook, 2000-present

Selected Publications

• Gifford A.N., Kuschel S., Shea C., and Fowler J.S.
  Polymer-supported organotin reagent for prosthetic group labeling of biological macromolecules with radioiodine.
  Bioconjugate Chemistry, (2011). [Epub ahead of print]  PubMed
• Gifford A.N., Espaillat M.P. and Gatley S.J.
  Biodistribution of radiolabeled ethanol in rodents.
  Drug Metab. Dispos., 36(9):1853-1858 (2008).  PubMed
• Tovar-Salazar A., Dhawan J., Lovejoy A., Liu Q.A. and Gifford A.N.
  Preparation of radioiodinated peptide nucleic acids with high specific activity.
  Anal. Biochem., 360(1):92-98 (2007).  PubMed
• Dhawan J., Deng H., Gatley S.J., Makriyannis A., Akinfeleye T., Bruneus M., DiMaio A.A. and Gifford A.N.
  Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[^125/131I]AM2233.
  Synapse, 60(2):93-101 (2006).  PubMed
• Glaser S.T., Gatley S.J. and Gifford A.N.
  Ex-vivo imaging of fatty acid amide hydrolase (FAAH) activity and its inhibition in the mouse brain.
  J. Pharmacol. Exp. Ther., 316(3):1088-1097 (2006).  PubMed
• Deng H., Gifford A.N., Zvonok A.M., Cui G., Li X., Fan P., Deschamps J.R., Flippen-Anderson J.L., Gatley S.J. and Makriyannis A.
  Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
  J. Med. Chem., 48(20):6386-6392 (2005).  PubMed

Last Modified: March 10, 2011
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One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by the Research Foundation of State University of New York on behalf of Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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