Andrew Gifford Scientist Telephone:  (631) 344-7069 e-mail: gifforda@bnl.gov

Research Interests

• Radiochemical labeling of biomolecules, especially with radiohalogens and/or radiolabeled prosthetic groups
• Simplifying radiolabeling procedures by investigating the use of new solid phase resins for labeling biomolecules.
• Autoradiographic imaging, including a project to image RNA expression using radiolabeled aptamer ligands.
• Radioligand binding assays.
• In vivo receptor occupancy studies.

 Education & Concurrent Positions

• B.S. University of London, 1985; Ph.D. University of St. Andrews, Scotland, 1989
• Post-Doctoral Fellow, University of Texas Medical Branch, 1990-1994
• Assistant Scientist, Medical Department, BNL, 1995-1997
• Associate Scientist, BNL 97-99, Scientist, 1999-present
• Faculty Member, Graduate Program in Neurobiology and Behavior, S.U.N.Y. at Stony Brook, 2000-present

Selected Publications

• Gifford A.N., Espaillat M.P. and Gatley S.J.
  Biodistribution of radiolabeled ethanol in rodents.
  Drug Metab. Dispos., 36(9):1853-1858 (2008).  PubMed
• Tovar-Salazar A., Dhawan J., Lovejoy A., Liu Q.A. and Gifford A.N.
  Preparation of radioiodinated peptide nucleic acids with high specific activity.
  Anal. Biochem., 360(1):92-98 (2007).  PubMed
• Dhawan J., Deng H., Gatley S.J., Makriyannis A., Akinfeleye T., Bruneus M., DiMaio A.A. and Gifford A.N.
  Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[^125/131I]AM2233.
  Synapse, 60(2):93-101 (2006).  PubMed
• Glaser S.T., Gatley S.J. and Gifford A.N.
  Ex-vivo imaging of fatty acid amide hydrolase (FAAH) activity and its inhibition in the mouse brain.
  J. Pharmacol. Exp. Ther., 316(3):1088-1097 (2006).  PubMed
• Deng H., Gifford A.N., Zvonok A.M., Cui G., Li X., Fan P., Deschamps J.R., Flippen-Anderson J.L., Gatley S.J. and Makriyannis A.
  Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
  J. Med. Chem., 48(20):6386-6392 (2005).  PubMed
• Gifford A.N., Makriyannis A., Volkow N.D. and Gatley S.J.
  In vivo imaging of the brain cannabinoid receptor.
  Chem. Phys. Lipids., 121(1-2):65-72 (2002).  PubMed

Last Modified: May 15, 2009
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One of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE's Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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