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A Medical Imaging and Radiation Therapy (MIRT) Beamline for the NSLS II

May 9, 2011

Brookhaven National Laboratory, Bldg. 817, Room 4

Workshop Chair: Avraham Dilmanian

We propose the development of a state-of-the-art medical imaging and radiation therapy beamline for the NSLS-II, building on the experience and success to date at NSLS.  The justifications for such a facility are a) the local expertise in medicine and technology in support of the ideas and demands of a diverse user community, and b) the specifications of the NSLS-II, making it one of the most suitable facilities anywhere for use in medical applications.  These specifications include the facilitys 3.0 GeV ring energy, 500 mA top-off ring current and low emittance, the possibility of a high field superconducting wiggler source for full field, wide fan-beam imaging, and prospects for having a long beam line for imaging of large animals and potentially human subjects.   Both basic research and preclinical studies in a wide range of applications will be conducted at the beam line.  The facility will attract a large number of investigators from the immediate neighborhood, from the rest of the United States, and from other countries.  The beamline will be competitive with the similar existing and planned facilities, globally.


Mark Anastasio, Washington Univ. / Fulvia Arfelli, Univ. Trieste / Dean Connor, Jr., Medical Univ. S. Carolina / Avraham Dilmanian, BNL / James Hainfeld, Nanoprobes, Inc. / Albert Hanson, BNL / Donald Harrington, Stony Brook Univ. / Arthur Jenkins, Mt. Sinai School of Medicine / Rob Lewis, Univ. Saskatchewan and Monash Univ. / Hector Lopez, NIBIB / William Moore, SB Radiology / Erik Ritman, Mayo Clinic / Qun Shen, BNL / Daniel Slatkin, MD / Henry Smilowitz, Univ. Connecticut / William Thomlinson, U. Saskatchewan / Zhong Zhong, BNL

Note: for those wishing to attend who do NOT have a valid BNL ID badge:

      1) Non-US citizens MUST register in the Guest Information System before April 29:

          2)  US citizens MUST send their names to by May 4  for BNL access.



Speakers, please allow 3-5 minutes for questions and answers.

Session 1 (morning):  Bill Thomlinson, Chair
9:00 - 9:15 Welcome and Introduction Qun Shen, BNL (PS)
09:15 - 09:20 Opening Remarks Avraham Dilmanian, BNL (Medical)
09:20 - 09:50 What should be the aims of developing the MIRT? Rob Lewis, U. Saskatchewan and Monash U.
09:50 - 10:00 Questions to be addressed about Biomedical Applications Erik Ritman, Mayo Clinic
10:00 - 10:20 Technical Features of the NSLS-II Medical Beamline Zhong Zhong, BNL (PS)
10:20 - 10:40 First Synchrotron Human Studies in Mammography Fulvia Arfelli, U. Trieste
10:40 Break  

Session 2 (morning):  Lisa Miller, Chair
10:55 - 11:15 Diffraction Enhanced Imaging (DEI) Dean Connor, Jr., Medical U. SC
11:15 - 11:35 Propagation Phase Contrast Imaging Mark Anastasio, Washington U.
11:35 - 12:00 Microbeam Radiation Therapy (MRT) Avraham Dilmanian, BNL (Medical)
12:00 Lunch  

Session 1 (afternoon):  Dean Connor Jr., Chair
1:00 - 1:15 NIBIB research interests and opportunities for new imaging modalities and therapy methods Hector Lopez, NIBIB
1:15 - 1:25 DEI of Excised Pig Hearts at the NSLS Donald Harrington, Stony Brook U.
1:25 - 1:45 Gold nanoparticles: X-ray imaging contrast agent and tumor dose enhancer James Hainfeld, Nanoprobes, Inc.
1:45 - 1:55 Immuno-targeting of tumors with and without gold nanoparticles: significance of synchrotron x rays Henry Smilowitz, U. Connecticut
1:55 - 2:15 X-ray contrast imaging: conventional x rays vs. monochromatic synchrotron beams William Moore, SB Radiology
2:15 - 2:30 Lessons from the past:  What aspects of medical research should be avoided at the NSLS-II? Daniel Slatkin, MD
2:30 - 2:40 Monte Carlo simulations for dose distribution from MRT Albert Hanson, BNL (NST)
2:40 - 3:00 Spinal cord injuries: current state of treatments Arthur Jenkins, Mt. Sinai School of Medicine
3:00 Break  

Session 2 (afternoon):  Rob Lewis, Chair
3:15 - 5:15 Panel discussion
Dean Connor, Avraham Dilmanian, Rob Lewis, Lisa Miller, Erik Ritman, Bill Thomlinson, Zhong Zhong
5:15 - 5:30 Concluding Remarks Bill Thomlinson, U. Saskatchewan

Administrative Contact:  Maria Anzaldi, telephone:  631-344-4838; email:

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