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Trends in Structural Biology

April 28-29, 2011

Brookhaven National Laboratory

Building 510 Large Seminar Room

Workshop Organizers: Patrick Loll (Drexel) and Vivian Stojanoff (BNL)

With the advent of the NSLS-II, it is a good time to take stock of the current state of the art in structural biology, and to look forward to what the future will bring. This meeting is intended to survey current research and develop a perspective on future themes in structural biology. Discussions will focus both on current methods and methods currently under development, with the goal of identifying advances that are most likely to benefit the field.


Mario Amzel, Johns Hopkins / Bert van den Berg, UMASS / Gino Cingolani, Thomas Jefferson U. / Roger Fourme, SOLEIL / James Holton, ALS / Veijo Honkimaki, ESRF / XianPeng Kong, NYU / Dean Madden, Dartmouth / Enrique Rudino, UNAM / Peter Siddons, Brookhaven National Lab. /, Gyorgy Snell, Takeda Pharmaceuticals / Yong Tang, Wistar Inst. / Michael Wiener, Univ. Virginia / Ji-Fang Zhang, Thomas Jefferson U. / Ming-Ming Zhou, MSSM



Thursday, April 28
Chair: Vivian Stojanoff
09:00 - 09:30 Opening Remarks Qun Shen, BNL (PS)
09:30 - 10:00 Protein Crystallography on Metalloenzmes Enrique Rudino, Universidad Autonoma Nacional de Mexico
10:00 - 10:15 Break  
Chair: Patrick Loll
10:15 - 10:45 Peptidylglycine Hydroxylating Monooxygenase: A Dicopper Hydroxylase Mario Amzel, Johns  Hopkins U.
10:45 - 11:15 MX and HPMX Using Higher Energy Photons: A New Paradigm Roger Fourme, SOLEIL
11:15 - 11:30 Break  
Chair: Saivenkatesh Seetharaman
11:30 - 12:00 TBA Ming-Ming Zhou, Mt. Sinai School of Medicine
12:00 - 12:30 Deciphering the Mechanism of the Pseudomonas Virulence Factor Cif Dean Madden, Dartmouth Medical School
12:30 - 1:30 Lunch  
Chair:  Lisa Miller
01:30 - 02:00 Life Science at the NSLS II Wayne Hendrickson, Columbia U.
02:00 - 02:30 Multisubunit ATPases:  Large, Complex and Essential Gino Cingolani, Thomas Jefferson U.
02:30 - 02:45 Break  
Chair: Qun Liu
02:45 - 03:15 How Do Greasy Molecules Enter Sugar-Coated Bacteria? Bert van den Berg, U. Mass. Med. School
03:15- 03:45 structures of anti-HIV Antibodies and HIV/AIDS Vaccine Discovery Xiangpeng Kong, New York U.
03:45 - 04:00 Break  
Chair: Jens Birktoft
04:00 - 04:30 The Optimum Wavelength for Macromolecular Crystallography James Holton, ALS
04:30 - 05:00 Diffraction at High Photon Energies Veijo Honkimaki, ESRF
05:00 - 06:00 Discussion leader:Pat Loll  
Friday, April 29
Chair:  Patrick Loll
09:00 - 09:30 Membrane Protein Structural Genomics: An Example, In Progress Michael Wiener, U. Virginia
09:30 - 10:00 Structural Basis for Calmodulin as a Versatile Calcium Sensor Ji-fang Zhang, Thomas Jefferson U.
10:00 - 10:15 Break  
Chair: Enrique Rudino
10:15 - 10:45 Structural and Functional Studies of N-Acetyltransferases that Target Histones and Beyond Yong Tang, Wistar Inst.
10:45 - 11:15 Protein Crystallography for Structure Based Drug Design: The Industrial Perspective Gyorgy Snell, Takeda Pharmaceuticals
11:15 - 11:30 Break  
Chair:  Veijo Honkimaki
11:30 - 12:00 Trends in X-ray Detectors Peter Siddons, BNL (PS)
12:00 - 1:00 Discussion leaders: Veijo Honkimaki and Gino Cingoglani  


Administrative Contact:  Lydia Rogers, telephone:  631-344-4746; email:

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