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Categories: advanced materials, nanotechnology

BSA 07-29 &13-17: DNA guided Nanoparticle Assemblies

BNL Reference Number: BSA 07-29

Patent Status: Application Number 20090275465 was published on November 5, 2009

Summary

A schematic of regulation of nanoparticle aggregation by functionalization with complementary, non-complementary, and partially rigid oligonucleotide strands

Nanoparticles tend to aggregate in solution, which is fine when that is the desired outcome. Functionalizing the nanoparticles with oligonucleotides (DNA, RNA, PNA) adds a degree of control over the aggregation. By using both single-stranded complementary oligonucleotides as well as non-interacting oligonucleotides to functionalize the nanoparticles, one can control the rate at which particles aggregate and the average size of the resulting aggregates.

Description

Two types of DNA with different functions are attached to particles' surfaces. The first type - complementary single strands of DNA - forms a double helix. The second type is non-complementary, neutral DNA, which provides a repulsive force.

Journal Publication

• DNA-regulated micro- and nanoparticle assembly (.pdf)

Have Questions?

For more information about this technology, contact Kimberley Elcess, (631) 344-4151.