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Categories: biotechnology & health, environment
BSA 02-16: Genome Signature Tags
BNL Reference Number: BSA 02-16
Patent Status: U.S. Patent Number 7,323,306 was issued on January 29, 2008
Summary
Computer simulations of the GSTs of two virtual samples containing ten organisms in which the relative amount of one of the organisms differs significantly between the two samples.
This method provides a comprehensive open-architecture means to examine collections of nucleic acid to assess populations of organisms as well as the identification of specific strains or sub-species within a sample.
Description
Describes a method of generating short genomic signature tags that can be sequenced to identify and quantify genomic DNAs.
Benefits
The method provides a fast, simple and an economical approach of genome-wide finger printing of chromosomal and episomal DNAs.
Applications and Industries
The method is useful for assessing populations of organisms in environmental and biological samples such as biofilms and potential bioterror weapons. Specific variants of the technology include analysis of methylation changes within CpG islands related to pathogenic conditions such as cancer.
Journal Publication
Press Releases
Have Questions?
For more information about this technology, contact Christine Brakel, (631) 344-7134.
Tags: diagnostic, DNA assay
