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General Information
Categories: biotechnology & health, environment
BSA 00-22: Assaying Clustered DNA Damages
BNL Reference Number: BSA 00-22
Patent Status: U.S. Patent Number 6,789,022 was issued on September 7, 2004
Summary
Schematic representation of damage to DNA.
Analysis of the exposure of cells to ionizing radiation and DNA-damaging chemicals is enabled by this simple technology. Closely spaced damage in DNA may result in irreparable damge, cell death or, in some cases uncontrolled cell proliferation. Measuring exposure and sensitivity to DNA-damaging agents is a simple procedure enabled by this method.
Description
Describes a method for detecting and quantifying clustered DNA damages induced by exposure of the biological organism to a DNA-damaging agent.
Benefits
The technique provides a sensitive reliable method of detecting and quantifying clustered damages in genomic DNAs or mixtures of DNAs of unknown DNA sizes. The method can be used to evaluate the biological impact of both low and high doses of radiation.
Applications and Industries
The technology can be used for evaluating the biological impact of exposure to ionizing radiation and monitoring the efficacy of radiation and chemotherapy protocols. In addition, the assay provides a method for assessing radiation damage to humans, crops, livestock and wildlife following a nuclear mishap.
Journal Publication
Press Releases
Have Questions?
For more information about this technology, contact Christine Brakel, (631) 344-7134.
Tags: diagnostic, DNA assay, DNA damage
