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Building 134
P.O. Box 5000
Upton, NY 11973-5000
phone 631 344-2345
fax 631 344-3368

managed for the U.S. Department of Energy
by Brookhaven Science Associates, a company
founded by Stony Brook University and Battelle

Informational Posting

Released: October 8, 2003
Contact: Karen McNulty Walsh, 631 344-8350, or Mona S. Rowe, 631 344-5056

2003 Nobel Prize in Chemistry Awarded to
Researcher Roderick MacKinnon

MacKinnon's Research Conducted at Brookhaven's National Synchrotron Light Source and Cornell's High Energy Synchrotron Source

Roderick MacKinnon, M.D., a visiting researcher at the U.S. Department of Energy's Brookhaven National Laboratory, has won half of this year's Nobel Prize in Chemistry for work explaining how a class of proteins helps to generate nerve impulses -- the electrical activity that underlies all movement, sensation, and perhaps even thought. The work leading to the prize was done primarily at the Cornell High Energy Synchrotron Source and the National Synchrotron Light Source at Brookhaven.

The proteins, called ion channels, are tiny pores that stud the surface of all of our cells. These channels allow the passage of potassium, calcium, sodium, and chloride molecules called ions. Rapid-fire opening and closing of these channels releases ions, moving electrical impulses from the brain in a wave to their destination in the body.

Starting in 1998, after 10 years studying the biophysics of ion channels, MacKinnon published a series of structural solutions -- high-resolution molecular-level "snapshots" of ion channels, produced at Cornell and Brookhaven. These structures literally showed the scientific community how electrical signaling occurs.

MacKinnon, a biophysicist and self-taught x-ray crystallographer, is a professor at Rockefeller University and an investigator at the Howard Hughes Medical Institute. He shares this year's chemistry Nobel with Peter Agre, M.D., of Johns Hopkins University School of Medicine.

Related information:
"MacKinnon lab’s newest picture tells action potential story", April 30 press release
Background information on the National Synchrotron Light Source
National Synchrotron Light Source website
Rockefeller University, Cornell High Energy Synchrotron Source, Howard Hughes Medical Institute, Nobel Prize press release.