At the Extreme Light Lab at the Air Force Research Laboratory, Dayton, we explore light matter interaction at relativistic fields with liquid targets. Although demonstrations of up to 4 GeV1 electrons and ~100 MeV protons2 have been achieved in the past, all of these are not feasible as future accelerators, due to their slow duty cycle (usually single shot, rarely 1 Hz). There are many challenges to increasing the duty cycle, where laser technology, target technology, damage to system, target alignment, high repetition rate sub-micron plasma diagnostics provides nearly insurmountable obstacles. In this program, we developed ways to accelerate MeV x-rays, electrons3 and ions4 at kHz repetition rate with a small milli-joule class laser system, by developing a combination of suitable laser system, diagnostic system, target system and experimental data collection system capable of handling the high duty cycle. We also perform femtosecond-time resolution pump-probe imaging of the interaction, and extensive large scale relativistic laser plasma interaction simulations5 that reveal the nature of the acceleration processes. Such a system opens the door to extensive future application as a source for materials processing, radiation hardness testing, medical isotope production, time resolved proton probing on relativistic interactions, and many others.