In the era of complex systems on chip (SoCs), clock and timing generation is required in nearly any application. These timing generators supply clock signals to digital modules, act as heartbeats for serial communication links or provide picosecond accurate reference information to time-interval sensors. Phase Locked Loops are the main building block that provide clock signals. However, in the high-energy physics community, ionizing radiation effects degrade these circuits significantly and produce soft-errors which can disturb an entire system. In this seminar, the application of these timing blocks in the high-energy physics are discussed together with the mitigation techniques for ionizing radiation.