Hosted by: Vivian Stojanoff

An odyssey in drug delivery study via X-ray microscopy approach We've used X-ray fluorescence microscopy (XRF) as a powerful chemical nano-imaging tool to study a few examples of anti-cancer drug with transition metal complexes (Os, Ir) and locate their target sites within human cancer cells. Throughout these studies, despite its high sensitivity, semi-quantitative, and versatility, XRF has also complemented other techniques such as soft X-ray microscopy, TEM, cryo light confocal microscopy, and hard X-ray phase contrast imaging to provide more complete pictures to uncover the potential delivery mechanisms. In addition, sample preparations including cryogenic preparation, as well as the transfer compatibility between various techniques, as a critical aspect, will also be discussed.