Rita Z. Goldstein, Ph.D.
Telephone: (631) 344-2657
e-mail: firstname.lastname@example.org ; see Neuropsychoimaging web site
Education & Concurrent
1/1992 B.A., Tel Aviv University, Tel Aviv,
Israel. Majors: Psychology and French (Cum Laude); 1998-1999 Intern,
Clinical Neuropsychology, Long Island Jewish Medical Center and Hillside Hospital, New
Hyde Park, NY; 8/1999 Ph.D., Dept. of Psychology, Health Clinical track,
University of Miami, FL (Award of Academic Merit); 1999 - 2002
Post-doctorate research associate, training fellowship on Brain Imaging and
Alcohol Abuse from the NIH, SUNY Stony Brook and Brookhaven National Laboratory,
Upton, NY; 1/2001 New York State Psychology License; 2002 Assistant Scientist, Medical
Research, Brookhaven National Laboratory, Upton, NY; 2002 Affiliate, Department of Psychology,
State University of NY at Stony Brook; 2003 Affiliate, Department of
Biomedical Engineering, State University of NY at Stony Brook; 2004 Associate
Scientist, Medical Research, Brookhaven National Laboratory, Upton, NY;
Scientist, Medical Research, Brookhaven National Laboratory, Upton, NY.
– 1998 Graduate Research
Assistantships, University of Miami, FL; 1994
– 1998 Letters of Commendation,
Department of Psychology, University of Miami, FL; 1997 – 1998
Graduate student travel scholarships, the Max and Peggy Kriloff
scholarship and U of Miami, FL; 1998 Stanley
Foundation Scholarship for research, Hillside Hospital, NY; 2003 – present Mentored
Patient-Oriented Research Career Development Award (K-23), NIDA; 2003
– present Young Investigator Award,
National Alliance for Research on Schizophrenia And Depression; 3/22/2005
Woman of the Year in Science, Brookhaven Town Award.
Neuroimaging, drug addiction, neuropsychology,
My primary research
interest lies in studying the interplay between the
cognitive-emotional-behavioral and neurobiological changes that accompany
cocaine addiction with the goal of understanding the mechanisms that
underlie the recurring nature of addiction to drugs (intoxication,
withdrawal, craving, relapse).
In this study of the
brain-behavior mechanisms that underlie drug addiction, I place a special
emphasis on the role of the prefrontal
cortex and the mesocortical and mesolimbic dopamine brain circuits in the
impaired ability to change ongoing
in response to an emotionally salient
This intricate study of
the interaction between brain and behavior incorporates the interrelated
yet distinct research disciplines of neuroimaging, cognitive neuroscience,
and neuropsychology. My research
embraces this multidisciplinary approach, translating into patient-oriented clinical research
settings the principles of non-invasive techniques to measure brain
function such as functional magnetic resonance imaging (fMRI),
positron emission tomography (PET), event-related potential (ERP) recordings, and neuropsychology.
see Neuropsychoimaging web site):
Subjects are currently being recruited for
1. Does salience of money change for drug
This is an ongoing
fMRI and ERP study where subjects are scanned in our 4 T scanner or ERPs
are recorded while performing a Go/No-Go task under varying monetary
conditions. See American Journal of Psychiatry, 164, 43-51,
2. How does salience of drug cues affect
attentional processes and inhibitory control in drug addiction?
This is a task we
have designed for fMRI in collaboration with Suparna
Rajaram, Ph.D., at SUNY Stony
Brook. See Neuroscience, 144, 1153-1159.
3. Applying computer science approaches to
the study of I-RISA
Here we apply
newly designed machine learning techniques to enhance our study of
addiction and other problem behavior (e.g., aggression). This is accomplished in collaboration
Samaras, Ph.D., at SUNY Stony Brook. See Proceedings 1-3, below.
4. The neuropsychology of drug addiction.
In this project,
we use neuropsychological assessment techniques to probe into the
cognitive-behavioral and personality-emotional correlates of drug
addiction. We use instruments such
as the Stroop and
Multidimensional Personality Questionnaire (MPQ) in combination with data
from functional neuroimaging studies to learn about cognition
(e.g., inhibitory control, planning and organization, decision-making,
salience attribution) and emotion (fear, anger) in drug addiction.
5. Prediction of
relapse in drug addiction.
Here we use
neuropsychological, fMRI and ERP results collected at a drug-free baseline to
predict relapse status at follow-up in cocaine addicted individuals. Collaborations:
Ph.D., at Columbia University; Rajita Sinha,
Ph.D., at Yale University School of Medicine.
learning and emotional regulation in drug addiction.
This is a new
project we have initiated in collaboration with Elizabeth
Phelps, Ph.D., at New York University, to study the neurobiological mechanisms underlying resistance
to reward extinction in cocaine addicted individuals.
Raz S, Goldstein R, Hopkins TL, Lauterbach
MD, Shah F, Porter CL, Riggs WW, MaGill LH, Sander CJ. (1994). Sex
differences in early vulnerability to cerebral injury and their
neurodevelopmental implications. Psychobiology,
R, Harvey AS, Duchowny M, Jayakar P, Altman N, Resnick T, Levin B, Dean P,
Alvarez L. (1996). Preoperative clinical, EEG, and imaging findings do not
predict seizure outcome following temporal lobectomy in childhood. Journal
of Child Neurology, 1(6), 445-450.
Goldstein RZ, Volkow ND, Wang G-J, Fowler JS, Rajaram S. (2001). Addiction changes
orbitofrontal gyrus function: involvement in response inhibition. NeuroReport,
Goldstein RZ, Hurwitz BE, Llabre MM, Schneiderman N, Gutt M, Skyler JS, Prineas RJ,
Donahue RP. (2001). Modeling preclinical cardiovascular risk for use in
epidemiologic studies: Miami community health study. American Journal of
Epidemiology, 154(8), 765-776.
RZ, Giovannetti T, Schullery TM, Zuffante P, Lieberman JA, Robinson DG,
Barr WB, Bilder RM. (2002). Neurocognitive correlates of response to
treatment in formal thought disorder in first-episode schizophrenia. Neuropsychiatry,
Neuropsychology, and Behavioral Neurology, 15(2), 88-98.
RZ, Volkow ND, Chang L, Wang G-J, Fowler JS, Depue RA, Gur RC. (2002). The
Orbitofrontal Cortex in Methamphetamine Addiction: Involvement in
Fear. NeuroReport, 13(17), 1-5.
Goldstein RZ, Volkow ND. (2002). Drug
Addiction and its Underlying Neurobiological Basis: Neuroimaging Evidence
for the Involvement of the Frontal Cortex. American Journal of Psychiatry, 159(10), 1642-1652.
*Cited >270 times.
Volkow ND, Fowler
JS, Wang G-J, Goldstein RZ.
(2002). Role of Dopamine and the Frontal Cortex in Drug Addiction In
Humans. Neurobiology of Learning and Memory, 78(3), 610-624.
Giovannetti T, Goldstein RZ, Schullery TM,
Barr WB & Bilder RM. (2003). Semantic
knowledge degradation does not explain reduced category fluency in first
episode schizophrenia patients.
Journal of the International Neuropsychological Society, 9, 384-393.
RZ, Leskovjan AC, Hoff AL,
Hitzemann R, Bashan F, Khalsa SS, Wang G-J, Fowler JS, Volkow ND. (2004). Severity
of neuropsychological impairment in drug addiction: association with
metabolism in the brain reward circuit. Neuropsychologia, 42, 1447-1458.
Goldstein RZ, Alia-Klein N,
Leskovjan AC, Fowler JS, Wang G-J, Gur RC, Hitzemann R, Volkow ND. (2005). Anger and depression in cocaine
addiction: association with the orbitofrontal cortex. Psychiatry
Research: Neuroimaging, 138, 13-22.
Volkow ND, Wang G-J, Begleiter H, Porjesz B, Fowler JS, Telang F, Ma
Y, Wong C, Logan J, Goldstein RZ, Thanos PK, Alexoff D. (2006). High
Dopamine D2 Receptors in Unaffected Members of Alcoholic Families: Possible
Protective Factors. Archives of General Psychiatry 63, 999-1008.
RZ, Cottone LA, Jia Z,
Volkow ND, and Squires NK. (2006). The effect of graded monetary reward
on cognitive event-related potentials and behavior in young healthy adults.
International Journal of Psychophysiology 62, 272-279.
RZ, Alia-Klein N, Tomasi D, Zhang L, Cottone LA, Maloney T, Telang F,
Caparelli EC, Chang L, Ernst T, Samaras D, Squires NK, and Volkow ND.
(2007). Decreased prefrontal cortical sensitivity to monetary reward
is associated with impaired motivation and self-control in cocaine
addiction. American Journal of Psychiatry, 164, 43-51.
RZ, Tomasi D, Alia-Klein N, Cottone LA, Zhang L, Telang F, and Volkow ND. (2006). Deficits in subjective sensitivity to
gradients in monetary reward in cocaine abusers are associated with
the orbitofrontal cortex.
and Alcohol Dependence, 87, 233-240.
RZ, Tomasi D, Alia-Klein N, Zhang L, Telang F, and Volkow ND. (2007).
The effect of practice on a sustained attention task in cocaine
abusers. Neuroimage, 35, 194-206.
RZ, Tomasi D, Rajaram S, Cottone LA, Zhang L, Maloney T, Telang F,
Alia-Klein N, and Volkow ND. (2007). Role of the anterior cingulate
and medial orbitofrontal cortex in processing drug cues in cocaine
addiction. Neuroscience, 144, 1153-1159.
RZ, Woicik PA, Lukasik T, Maloney T, Volkow ND. (2007). Drug
Fluency: A Potential Marker for Current Cocaine Abuse. Drug and
Alcohol Dependence 89, 97-101.
D, Goldstein RZ, Telang F, Maloney T, Alia-Klein N, Caparelli
EC, Volkow ND. Thalamo-cortical dysfunction in cocaine abusers:
implications in attention and perception. Psychiatry Research:
Neuroimaging 155, 189-201.
N, O'Rourke T, Goldstein RZ, Malaspina D. (2007). Insight into
illness and adherence to psychotropic medications predict violence
severity in a forensic sample. Aggressive Behavior, 33, 86-96.
N, Goldstein RZ, Tomasi D, Zhang L, Telang F, Wang G-J, Fowler
JS, Volkow ND. What is in a word? No versus Yes differentially
activate the lateral orbitofrontal cortex. Emotion 7(3), 649-659.
JS, Alia-Klein N, Kriplani A, Logan J, Williams B, Zhu W, Craig IW,
Telang F, Goldstein R, Volkow ND, Vaska P, Wang G-J. Evidence
that brain MAO A activity does not correspond to MAO A genotype in
healthy male subjects. Biological Psychiatry 62, 355-358.
D, Goldstein RZ, Telang F, Maloney T, Alia-Klein N, Caparelli
EC, Volkow ND. Widespread disruption in brain activation patterns to a
working memory task during cocaine abstinence. Brain Research 1171,
R, Goldstein RZ, Wang G-J, Wong C, Volkow ND. (2007). Incentive
motivation is associated with asymmetry in striatal markers of
dopamine neurotransmission. Biological Psychology 77(1), 98-101.
N, Goldstein RZ, Logan
J, Tomasi D, Kriplani A, Telang F, Shumay E,
Biegon A, Henn F, Wang G-J, Volkow ND,
Fowler JS. Brain MAO A Activity Associated with Trait
Aggression. Journal of Neuroscience, 28(19), 5099-5104.
PA, Moeller SJ, Alia-Klein N, Maloney T, Lukasik T, Yeliosof O, Wang
G-J, Volkow ND, Goldstein RZ. (2008). The
Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks
N, Kriplani A, Pradhan K, Ma J-Y, Logan J, Williams B, Craig IW,
Telang F, Tomasi D, Goldstein RZ, Wang G-J, Volkow ND, Fowler
The MAO A genotype does not modulate resting brain
metabolism in adults. Psychiatry
Research: Neuroimaging, in press.
RZ, Parvaz MA, Maloney T, Alia-Klein N, Woicik PA, Telang F, Wang G-J,
Volkow ND. (2008).
Compromised sensitivity to monetary reward in current cocaine users:
an ERP study. Psychophysiology 45, in press.
Zhang L, Samaras D, Volkow ND,
Goldstein R. (2005).
Machine Learning for Clinical Diagnosis
from Functional Magnetic Resonance Imaging (#169).
In IEEE Proc. of Computer Vision and Pattern Recognition,I:1211-1217.
Zhang L, Samaras D, Tomasi D, Alia-Klein N, Cottone LA, Leskovjan
LC, Volkow ND, Goldstein R. (2005).
Exploiting Temporal Information in
Functional Magnetic Resonance Imaging Brain Data.
Medical Image Computing
and Computer Assisted Intervention, pp.679-687.
Zhang L, Samaras D, Alia-Klein N, Volkow ND, Goldstein
R. (2006). Modeling
Neuronal Interactivity using Dynamic Bayesian Networks. 12.
In Advances in Neural Information Processing Systems 18,
B. Scholkopf, and J. Platt, Eds. MIT Press, Cambridge, MA.
Hurwitz BE, Goldstein
R, Massie CA, Llabre MM, Schneiderman N. (2000). Low-flow circulatory state
and the pathophysiological development of
cardiovascular disease: A
model of autonomic mediation of cardiovascular regulation. In P.M. McCabe, N. Schneiderman, T.
Field, & A. R. Wellens (Eds.), Stress, Coping, and Cardiovascular
Disease. Lawrence Erlbaum Associates. Mahwah, NJ, pp 85-122.
RZ, Alia-Klein N, Cottone LA, Volkow ND.
Addiction and the Orbitofrontal Cortex. In D Zald & S Rauch (Eds.), The
Orbitofrontal Cortex. Oxford University Press.
Volkow ND, Wang G-J, Fowler JS, Goldstein RZ.
(2006). Imaging the Addicted Brain. In
BK Madras, CM Colvis, JD Pollock, JL Rutter, D Shurtleff, & MV
Zastrow (Eds.), Cell
Biology of Addiction. The Cold Spring Harbor Laboratory Press.
RZ, Alia-Klein N, Volkow ND. (2008).
Drugs of Addiction:
Neuroimaging. In Larry R Squire, Editor-in-Chief, Encyclopedia of
Neuroscience, Academic Press, Oxford.
Interviews in Media
Brain Matter, North
Shore Sun, by A. Clancy, 10/25/02.
Brains Work Harder to Control Behavior, Press release by Brookhaven
National Laboratory, 12/3/02.
documentary of drug addiction for the RAI Italian National TV
Marco Rosi of DocLab Productions, 2006.
Perception of Reward in Human Cocaine Addiction, Press release by Brookhaven
National Laboratory, 10/15/06. Appeared also on: http://www.medicalnewstoday.com.
drug skews values, Newsday, by J.
alters brain cells, impairs impulse control, Reuters Health, by M.
Leonard Lopate Show on WNYC, New York Public Radio: Brief Histories,
Please Explain: Cocaine, 01/12/07. Listen
or download from: http://www.wnyc.org/shows/lopate/episodes/2007/01.
Addiction, Congressional Quarterly Research, by M. Clemmitt, 2/9/07.
of addiction lures researchers: complex network of brain mechanisms
underlies cravings, San
Francisco Chronicle, by C. Hall, 2/11/07.
with six leading neuroscientists on timely topics in brain research:
Addiction and the +Prefrontal Cortex, Dana
Foundation Press: featured in the 2007 Advances in Brain Research:
Brain Work, by B. Patoine, 2/28/07.
of Substance, interview and TV documentary on alcoholism, substance
abuse and mental health, Suffolk County Dept. of Health
Services, by M. Myers, aired April, 2007.