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X-ray Scattering for Biological Applications at NSLS-II

June 2-3, 2010

Brookhaven National Laboratory, Bldg. 725, Seminar Room

Workshop Organizer:  Lin Yang

The purpose of this workshop is to explore the scientific programs that will be hosted by the two biological X-ray scattering beamlines that we propose to develop at NSLS-II. One of these beamlines will take advantage of the NSLS-II source brightness and be specialized in three scientific areas: time-resolved solution scattering, membrane structures, and scanning-probe imaging of biological tissues. The other will be a highly automated, dedicated biomolecular solution scattering beamline. All members of the life science user community are invited to attend and contribute ideas to define the scientific programs as well as beamline prarameters. Some description and preliminary performance analysis of these two beamlines can be found here: bioSAXS-NSLSII.


Marc Allaire, BNL / Osman Bilsel, University of Massachusetts /  Dax Fu, BNL /  Tom Irving, IIT and APS / Stefan Judex, SUNY � Stony Brook / Shenping Liu, Pfizer / Andreas Menzel, SLS / Lois Pollack, Cornell University / Dan Raleigh, SUNY � Stony Brook / Jeff Ruberti, Northeastern University / Hiro Tsuruta, SSRL / Lin Yang, BNL / Sichun Yang, University of Chicago and Case Western

 Note: for those wishing to attend who do NOT have a valid BNL ID badge:

      1) Non-US citizens MUST register in the Guest Information System before May 26:

          2)  US citizens MUST send their names to by May 28  for BNL access.



Wednesday, June 2, 2010

8:30 - 8:45 Lin Yang (BNL) Introduction, Workshop Goals
8:45 - 10:45 Technical Session
  a.   Review of the existing technical capabilities and scientific programs
        Tom Irving (IIT/APS): BioCAT
        Andreas Menzel (SLS): European high brightness bioSAXS beamlines
        Hiro Tsuruta (SSRL): Biological x-ray scattering/diffraction facilities at SSRL: high throughput and time-                                     resolved studies
  b.   Proposed NSLS-II beamlines (Lin Yang, BNL)
10:45 - 11:15 Break
11:15 - 12:15 Scientific Session
  a.   Time-resolved solution scattering (chair: Dan Raleigh, SUNY-SB)
        Lois Pollack (Cornell):   Flow cells for microsecond and millisecond solution scattering
        Osman Bilsel (U Mass):   Simultaneous fluorescence and X-ray scattering measurements
12:15 - 13:15 Lunch break (at the meeting location, discussion continues through lunch)
13:15 - 15:15 Scientific Session continued
  b.   Membrane structures (chair: Lin Yang, BNL)
        Dax Fu (BNL): Challenges in membrane protein structure determination 
       Huey Huang (Rice U.), presented by Lin Yang: Structures in membranes 
  c.   Scanning probe imaging of tissues (chair: Andreas Menzel, SLS)
        Jeff Ruberti (Northeastern U): Natural and engineered collagenous structures 
        Stefan Judex (SUNY-SB): Perspective on X-ray scattering in bone research 
15:15 - 15:45 Break
15:45 - 17:30 Scientific Session continued
  d.   High throughput (chair: Marc Allaire, BNL)
        Shenping Liu (Pfizer): Industrial use of SAXS 
        Sichun Yang (U Chicago/Case Western): High throughput SAXS for ligand screening and structural genomics
17:30 Discussion

Thursday, June 3, 2010

9:00 - 12:00 Discussions on proposal content, proposal teams and BAT membership

Administrative Contact:  Lydia Rogers, telephone:  631-344-4746; email:

Last Modified: April 2, 2013
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