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Dr. Thanos



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Peer Reviewed Articles


  • Thanos PK, Bermeo C., Wang G.J., and Volkow N.D.
    D-cycloserine facilitates extinction of cocaine self administration in rats.
    Synapse, (2011 Feb 25). doi: 10.1002/syn.20922. [Epub ahead of print]
    PMID:21360592 (PDF)
  • Volkow ND, Fowler JS, Wang GJ, Shumay E, Telang F, Thanos PK, Alexoff D.
    Distribution and pharmacokinetics of methamphetamine in the human body: clinical implications.
    PLoS One. 2010 Dec 7;5(12):e15269.
    PMID:21151866  PMCID:PMC2998419  (PDF)
  • Thanos PK, Cho J, Kim R, Michaelides M, Primeaux S, Bray G, Wang GJ, Volkow ND.
    Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats.
    Behav Brain Res. 2011 Feb 2;217(1):165-70. Epub 2010 Oct 27.
    PMID:21034777  (PDF)
  • Thanos PK, Gopez V, Delis F, Michaelides M, Grandy DK, Wang GJ, Kunos G, Volkow ND.
    Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.
    Alcohol Clin Exp Res. 2011 Jan;35(1):19-27. doi: 10.1111/j.1530-0277.2010.01318.x. Epub 2010 Oct19.
    PMID:20958329  PMCID: PMC3004984  (PDF)
  • Thanos PK, Kim R, Cho J, Michaelides M, Anderson BJ, Primeaux SD, Bray GA, Wang GJ, Robinson JK, Volkow ND.
    Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats.
    Physiol Behav. 2010 Dec 2;101(5):713-8. Epub 2010 Aug 27.
     PMID: 20801137  (PDF)
  • Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, Desco M, Rubinstein M, Volkow ND, Thanos PK.
    Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate.
    Eur J Neurosci. 2010 Aug;32(4):668-76. Epub 2010 Jul 16.
    PMID:20646063 PMCID: PMC2938021  (PDF)
  • Thanos PK, Tucci A, Stamos J, Robison L, Wang GJ, Anderson BJ, Volkow ND.
    Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats.
    Behav Brain Res. 2010 Dec 20;215(1):77-82. Epub 2010 Jul 6.
    PMID:20615434  (PDF)
  • Pfaffly J, Michaelides M, Wang GJ, Pessin JE, Volkow ND, Thanos PK.
    Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice.
    Synapse. 2010 Jul;64(7):503-10.
     PMID:20175225  PMCID: PMC2873172  (PDF)
  • Thanos PK, Habibi R, Michaelides M, Patel UB, Suchland K, Anderson BJ, Robinson JK, Wang GJ, Grandy DK, Volkow ND.
    Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.
    Behav Brain Res. 2010 Mar 5;207(2):508-11. Epub 2009 Oct 22.
     PMID:19853629  PMCID: PMC2815086  (PDF)
  • Thanos PK, Ivanov I, Robinson JK, Michaelides M, Wang GJ, Swanson JM, Newcorn JH, Volkow ND.
    Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.
    Pharmacol Biochem Behav. 2010 Jan;94(3):374-9. Epub 2009 Oct 8.
    PMID:19818805  (PDF)
  • Thanos PK, Bermeo C, Rubinstein M, Suchland KL, Wang GJ, Grandy DK, Volkow ND.
    Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.
    J Psychopharmacol. 2010 Jun;24(6):897-904. Epub 2009 Mar 12.
    PMID:19282420  PMCID:PMC2878389  (PDF)
  • Wang GJ, Volkow ND, Telang F, Jayne M, Ma Y, Pradhan K, Zhu W, Wong CT, Thanos PK, Geliebter A, Biegon A, Fowler JS.
    Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation.
    Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1249-54. Epub 2009 Jan 21.
    PMID:19164587  PMCID:PMC2633545  (PDF)
  • Thanos PK, Bermeo C, Wang GJ, Volkow ND.
    D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice.
    Behav Brain Res. 2009 May 16;199(2):345-9. Epub 2008 Dec 30.
    PMID:19152811  PMCID:PMC2653598 (PDF)
  • Thanos PK, Wang G, Volkow ND.
    Positron Emission Tomography As A Tool For Studying Alcohol Abuse.
    Alcohol Research & Health 31 (3) 2008: 233-237
  • Zhang S, Zhou J, Wang X, Chang S, Pappas G, Delis F, Volkow ND, Wang G, Thanos PK.
    3D Segmentation Of Rodent Brains Using Deformable Models And Variational Methods.
    Mathematical Methods in Biomedical Image Analysis, Miami, Florida, June 20th 2009
  • Thanos PK, Bermeo C, Rubinstein M, Suchland K, Wang G, Grandy D, Volkow N.
    Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.
    J Psychopharmacol. 2009 Apr 7. [Epub ahead of print]
    PMID:19282420  PMCID:PMC2878389  (PDF)
  • Wang GJ, Volkow ND, Telang F, Jayne M, Ma Y, Pradhan K, Zhu W, Wong CT, Thanos PK, Geliebter A, Biegon A, Fowler JS.
    Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation.
    Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1249-54.
    PMID: 19164587  (PDF)
  • Thanos PK, Bermeo C, Wang GJ, Volkow ND.
    D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice.
    Behav Brain Res. 2009 May 16;199(2):345-9.
    PMID:19152811  (PDF)
  • Davis LM, Michaelides M, Cheskin LJ, Moran TH, Aja S, Watkins PA, Pei Z, Contoreggi C, McCullough K, Hope B, Wang GJ, Volkow ND, Thanos PK.
    Bromocriptine Administration Reduces Hyperphagia and Adiposity and Differentially Affecxcts Dopamine D2 Receptor and Transporter Binding in Leptin-Receptor-Deficient Zucker Rats and Rats with Diet-Induced Obesity.
    Neuroendocrinology. 2008 Nov 4. [Epub ahead of print]
    PMID: 18984941  (PDF)
  • Volkow ND, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Alia-Klein N, Logan J, Wong C, Thanos PK, Ma Y, Pradhan K.
    Inverse Association Between BMI and Prefrontal Metabolic Activity in Healthy Adults.
    Obesity (Silver Spring). 2008 Oct 23. [Epub ahead of print]
    PMID: 18948965  (PDF)
  • Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Wong C, Ma J, Pradhan K, Tomasi D, Thanos PK, Ferré S, Jayne M.
    Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain.
    J Neurosci. 2008 Aug 20;28(34):8454-61.
    PMID: 18716203  (PDF)
  • Pascau J, Gispert JD, Michaelides M, Thanos PK, Volkow ND, Vaquero JJ, Soto-Montenegro ML, Desco M.
    Automated Method for Small-Animal PET Image Registration with Intrinsic Validation. oimage.
    Mol Imaging Biol. 2008 Aug 1.
    PMID: 18670824  (PDF)
  • Volkow ND, Wang GJ, Telang F, Fowler JS, Thanos PK, Logan J, Alexoff D, Ding YS, Wong C, Ma Y, Pradhan K.
    Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors.
    Neuroimage. 2008 Oct 1;42(4):1537-43.
    PMID: 18598772  (PDF)
  • Thanos PK, Ramalhete RC, Michaelides M, Piyis YK, Wang GJ, Volkow ND.
    Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions.
    Synapse. 2008 Sep;62(9):637-42.
    PMID: 18563836  (PDF)
  • Vinod KY, Yalamanchili R, Thanos PK,Vadasz C, Cooper TB, Volkow ND, Hungund BL.
    Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
    Synapse. 2008 Aug;62(8):574-81.
    PMID: 18509854  (PDF)
  • Thanos PK, Michaelides M, Gispert JD, Pascau J, Soto-Montenegro ML, Desco M, Wang R, Wang GJ, Volkow ND.
    Differences in response to food stimuli in a rat model of obesity: in-vivo assessment of brain glucose metabolism.
    Int J Obes (Lond). 2008 Jul;32(7):1171-9.
    PMID: 18475275  (PDF)
  • Thanos PK, Michaelides M, Umegaki H, Volkow ND.
    D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
    Synapse. 2008 Jul;62(7):481-6.
    PMID: 18418874  (PDF)
  • Thanos PK, Cavigelli SA, Michaelides M, Olvet DM, Patel U, Diep MN, Volkow ND.
    A non-invasive method for detecting the metabolic stress response in rodents: Characterization and disruption of the circadian corticosterone rhythm.
    Physiol Res. 2008 Apr 1 [Epub ahead of print]
    PMID: 18380537  (PDF)
  • Thanos PK, Michaelides M, Ho CW, Wang GJ, Newman AH, Heidbreder CA, Ashby CR Jr, Gardner EL, Volkow ND.
    The effects of two highly selective dopamine D(3) receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity.
    Pharmacol Biochem Behav. 2008 Jun;89(4):499-507. Epub 2008 Feb 8.
    PMID: 18329700  (PDF)
  • Thanos PK, Michaelides M, Benveniste H, Wang GJ, Volkow ND.
    The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice.
    Synapse. 2008 May;62(5):319-24.
    PMID: 18286542  (PDF)
  • Wang GJ, Tomasi D, Backus W, Wang R, Telang F, Geliebter A, Korner J, Bauman A, Fowler JS, Thanos PK, Volkow ND.
    Gastric distention activates satiety circuitry in the human brain.
    Neuroimage. 2008 Feb 15;39(4):1824-31.
    PMID: 18155924  (PDF)
  • Thanos PK, Michaelides M, Piyis YK, Wang GJ, Volkow ND.
    Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([(11)C] raclopride) and in-vitro [(3)H] spiperone) autoradiography.
    Synapse. 2008 Jan;62(1):50-61
    PMID: 17960763  (PDF)
  • Thanos PK, Michaelides M, Benveniste H, Wang GJ, Volkow ND.
    Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.
    Pharmacol Biochem Behav. 2007 Oct;87(4):426-433
    PMID: 17599397  (PDF)
  • Rodriguez-Gomez JA, Lu JQ, Velasco I, Rivera S, Zoghbi SS, Liow JS, Musachio JL, Chin FT, Toyama H, Seidel J, Green MV, Thanos PK, Ichise M, Pike VW, Innis RB, McKay RD.
    Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson's disease.
    Stem Cells. 2007 Apr;25(4):918-28
    PMID: 17170065  (PDF)
  • Wang GJ, Yang J, Volkow ND, Telang F, Ma Y, Zhu W, Wong CT, Tomasi D, Thanos PK, Fowler JS
    Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry.
    Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15641-5.
    PMID:17023542  (PDF)
  • Volkow ND, Wang GJ, Begleiter H, Porjesz B, Fowler JS, Telang F, Wong C, Ma Y, Logan J, Goldstein R, Alexoff D, Thanos PK.
    High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.
    Arch Gen Psychiatry. 2006 Sep;63(9):999-1008
    PMID: 16953002  (PDF)
  • Onorae Rice, Sandra Saintvictor, Michael Michaelides, Panayotis K. Thanos, Samuel J. Gatley.
    MicroPET Investigation of Chronic Long-Term Neurotoxicity from Heavy Ion Irradiation.
    AAPS Journal 2006; 8 (3) Article 60
    PMID: 17025269  (PDF)
  • Panayotis K. Thanos, Elias S. Dimitrakakis, Onarae Rice, Andrew Gifford, Nora D. Volkow.
    Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors.
    Behavioral Brain Research 164 (2005) 206-213
    PMID: 16140402  (PDF)
  • Nora D. Volkow, Gene-Jack Wang, Dinko Franceschi, Joanna S. Fowler, Panayotis (Peter) K. Thanos, Laurence Maynard, S. John Gatley, Christopher Wong, Richard L. Veech, George Kunos & Ting-Kai Li.
    Low Doses of Alcohol Substantially Decrease Glucose Metabolism in the Human Brain.
    Neuroimage (2006) 295-301
    PMID: 16085426  (PDF)
  • Christian A. Heidbreder, Eliot L. Gardner, Zheng-Xiong Xi, Panayotis K. Thanos, Manolo Mugnaini, Jim J. Hagan, Charles R. Ashby Jr.
    The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence.
    Brain Research Reviews Vol 49(1)pp 77-105
    PMID: 15960988  (PDF)
  • Panayotis K. Thanos, John M. Katana, Charles R. Ashby Jr., Michael Michaelides,Eliot L. Gardner, Christian A. Heidbreder, Nora D. Volkow
    The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats. Pharmacology, Biochemistry and Behavior 81 (2005) 190-197
    PMID: 15894078  (PDF)
  • Panayotis K. Thanos T, Seth N. Rivera, Katrina Weaver, David K. Grandy,Marcelo Rubinstein, Hiroyuki Umegaki, Gene Jack Wang, Robert Hitzemann, Nora D. Volkow
    Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking.
    Life Sciences 77 (2005)130-139
    PMID: 15862598  (PDF)
  • Wang GJ, Volkow ND, Thanos PK, Fowler JS.
    Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review.
    J Addict Dis. 2004;23(3):39-53.
    PMID:15256343  (PDF)
  • Ding YS, Gatley SJ, Thanos PK, Shea C, Garza V, Xu Y, Carter P, King P,Warner D, Taintor NB, Park DJ, Pyatt B, Fowler JS, Volkow ND.
    Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration.
    Synapse 2004 Sep 1;53(3):168-75.
    PMID: 15236349  (PDF)
  • Heidbreder CA, Andreoli M, Marcon C, Thanos PK, Ashby CR Jr, Gardner EL.
    Role of dopamine D3 receptors in the addictive properties of ethanol.
    Drugs Today (Barc). 2004 Apr;40(4):355-65. Review.
    PMID: 15190388  (PDF)
  • Thanos PK, Taintor NB, Rivera SN, Umegaki H, Ikari H, Roth G, Ingram DK,Hitzemann R, Fowler JS, Gatley SJ, Wang GJ, Volkow ND.
    DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking.
    Alcohol Clin Exp Res. 2004 May;28(5):720-8.
    PMID: 15166646  (PDF)
  • Alexoff DL, Vaska P, Marsteller D, Gerasimov T, Li J, Logan J, Fowler JS,Taintor NB, Thanos PK, Volkow ND.
    Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity.
    J Nucl Med. 2003 May;44(5):815-22.
    PMID: 12732684  (PDF)
  • Thanos PK, Okajima S, Tiangco DA, Terzis JK.
    Insulin-like growth factor-I promotes nerve regeneration through a nerve graft in an experimental model of facial paralysis.
    Restor Neurol Neurosci. 1999;15(1):57-71.
    PMID: 12671244  (PDF)
  • Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Shou LL, Williams RW.
    Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes.
    Alcohol Clin Exp Res. 2003 Jan;27(1):1-11.
    PMID: 12543998  (PDF)
  • Thanos PK, Taintor NB, Alexoff D, Vaska P, Logan J, Grandy DK, Fang Y, Lee JH, Fowler JS, Volkow ND, Rubinstein M.
    In vivo comparative imaging of dopamine D2 knockout and wild-type mice with(11)C-raclopride and microPET.
    J Nucl Med. 2002 Nov;43(11):1570-7.Erratum in: J Nucl Med 2003 Jan;44(1):76.
    PMID: 12411561  (PDF)
  • Volkow ND, Wang GJ, Fowler JS, Thanos PP, Logan J, Gatley SJ, Gifford A,Ding YS, Wong C, Pappas N, Thanos PK.
    Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study.
    Synapse. 2002 Nov;46(2):79-82.Erratum in: Synapse. 2003 Mar 15;47(4):295. Thanos Pether [corrected to Thanos Panayotis Peter K].
    PMID: 12211085  (PDF)
  • Thanos PK, Volkow ND, Freimuth P, Umegaki H, Ikari H, Roth G, Ingram DK,Hitzemann R.
    Overexpression of dopamine D2 receptors reduces alcohol self-administration.
    J Neurochem. 2001 Sep;78(5):1094-103.
    PMID: 11553683  (PDF)
  • Thanos PK, Tiangco DA, Terzis JK.
    Enhanced reinnervation of the paralyzed orbicularis oculi muscle after insulin-like growth factor-I (IGF-I) delivery to a nerve graft.
    J Reconstr Microsurg. 2001 Jul;17(5):357-62.
    PMID: 11499470  (PDF)
  • Wang GJ, Volkow ND, Franceschi D, Fowler JS, Thanos PK, Scherbaum N, Pappas N, Wong CT, Hitzemann RJ, Felder CA.
    Regional brain metabolism during alcohol intoxication.
    Alcohol Clin Exp Res. 2000 Jun;24(6):822-9.
    PMID: 10888070  (PDF)
  • Volkow ND, Wang GJ, Fowler JS, Franceschi D, Thanos PK, Wong C, Gatley SJ,Ding YS, Molina P, Schlyer D, Alexoff D, Hitzemann R, Pappas N.
    Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions.
    Life Sci. 2000 Feb 11;66(12):PL161-7.
    PMID:10737368  (PDF)
  • Thanos PK, Okajima S, Terzis JK.
    Ultrastructure and cellular biology of nerve regeneration.
    J Reconstr Microsurg. 1998 Aug;14(6):423-36. Review.
    PMID: 9734847  (PDF)
  • Thanos PK, Slotnick BM.
    Short-term odor memory: effects of posterior transection of the lateral olfactory tract in the rat.
    Physiol Behav. 1997 Jun;61(6):903-6.
    PMID: 9177565  (PDF)
  • Terzis JK, Sun DD, Thanos PK,.
    Historical and basic science review: past, present, and future of nerve repair.
    J Reconstr Microsurg. 1997 Apr;13(3):215-25. Review.
    PMID: 9101452  (PDF)
  • Thanos PK, Terzis JK.
    A histomorphometric analysis of the cross-facial nerve graft in the treatment of facial paralysis.
    J Reconstr Microsurg. 1996 Aug;12(6):375-82.
    PMID:8866377  (PDF)
  • Thanos PK, Terzis JK.
    Motor endplate analysis of the denervated and reinnervated orbicularis oculi muscle in the rat.
    J Reconstr Microsurg. 1995 Nov;11(6):423-8.
    PMID: 8583455  (PDF)
  • Thanos PK, Jhamandas K, Beninger RJ.
    N-methyl-D-aspartate unilaterally injected into the dorsal striatum of rats produces contralateral circling: antagonism by 2-amino-7-phosphonoheptanoic acid and cis-flupenthixol. Brain Res. 1992 Aug 28;589(1):55-61.
    PMID: 1422822  (PDF)




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