Wednesday, February 21, 2007, 3:00 pm — Room 300, Chemistry Department, Bldg. 555
Viruses present an elegant example of spontaneous assembly. Their highly monodisperse particles can carry genetic information as well as present novel templates for nanomaterials. In this talk we look at the nature of the genome binding in RNA viruses, using known chemical sequences and structural data. A universal model, based simply on non-specific electrostatic interactions, is able to predict such essential aspects of viruses as the genome size, its density distribution, and energetics of assembly. Our result is in contrast to the view that specific interactions between sequenced amino acid residues and nucleotides control genome binding. Implications of this finding in biotechnology, nanoassembly, and evolution will be discussed.
Hosted by: Mark Hybertsen
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