Center for Biomolecular Structure Lecture Series

"CBMS Lecture Series"

Presented by Andres Finzi, Associate Professor, Faculty of Medicine, Université de Montréal, Canada

Wednesday, December 14, 2022, 3:45 pm — Videoconference / Virtual Event (see link below)

Modulating HIV-1 Env conformation to eliminate infected cells

HIV-1 evolved to conceal its envelope glycoproteins (Env) from recognition by antibodies elicited in most infected individuals. This lack of recognition translates into a lack of neutralization. Therefore, these antibodies are known as non-neutralizing antibodies (nnAbs). However, antibodies have several functions beyond neutralization, with Fc-effector functions being scrutinized in the last few years. Unfortunately, nnAbs also fail to eliminate infected cells due to their incapacity to recognize Env. We developed a new strategy to "open up" Env at the surface of infected cells thus enabling recognition by nnAbs. This approach renders infected cells susceptible to antibody-dependent cellular cytotoxicity (ADCC) and therefore it could represent a new tool to achieve a functional cure.

Hosted by: Vivian Stojanoff

Videoconference Instructions

Registration required

Join Videoconference

18269  |  INT/EXT  |  Events Calendar


Not all computers/devices will add this event to your calendar automatically.

A calendar event file named "calendar.ics" will be placed in your downloads location. Depending on how your device/computer is configured, you may have to locate this file and double click on it to add the event to your calendar.

Event dates, times, and locations are subject to change. Event details will not be updated automatically once you add this event to your own calendar. Check the Lab's Events Calendar to ensure that you have the latest event information.