Wednesday, December 14, 2022, 3:45 pm — Videoconference / Virtual Event (see link below)
Modulating HIV-1 Env conformation to eliminate infected cells
HIV-1 evolved to conceal its envelope glycoproteins (Env) from recognition by antibodies elicited in most infected individuals. This lack of recognition translates into a lack of neutralization. Therefore, these antibodies are known as non-neutralizing antibodies (nnAbs). However, antibodies have several functions beyond neutralization, with Fc-effector functions being scrutinized in the last few years. Unfortunately, nnAbs also fail to eliminate infected cells due to their incapacity to recognize Env. We developed a new strategy to "open up" Env at the surface of infected cells thus enabling recognition by nnAbs. This approach renders infected cells susceptible to antibody-dependent cellular cytotoxicity (ADCC) and therefore it could represent a new tool to achieve a functional cure.
Hosted by: Vivian Stojanoff
18269 | INT/EXT | Events Calendar
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