CBMS Lecture Series

Presented by Amir Khan, Harvard University

Wednesday, September 20, 2023, 1:30 pm — Videoconference / Virtual Event (see link below)

Structural biology of phospho-dependent signaling in the context of LRRK2 kinase and Parkinson's disease Activation of LRRK2 kinase activity has long been associated with inherited and sporadic forms of Parkinson's disease. However, the molecular basis for the defects in subsequent cell signaling that lead to neuronal cell death remain unknown. LRRK2 phosphorylates numerous Rab small GTPases and takes control of their functions in the regulation of vesicular and membrane trafficking. Here I will discuss how LRRK2 affects downstream cell signaling complexes using biophysical and structural techniques. These studies contribute to our understanding of how LRRK2-mediated phopshorylation is linked to neurodegeneration in the context of Parkinson's disease.

Hosted by: Vivian Stojanoff

Videoconference Instructions

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