Center for Biomolecular Structure Lecture Series

"CBMS Lecture Series"

Presented by Erik Debler, Thomas Jefferson University

Wednesday, January 24, 2024, 1:30 pm — Videoconference / Virtual Event (see link below)

Abstract: Kinetoplastid parasites are medically important eukaryotes that are responsible for severe neglected tropical diseases including sleeping sickness caused by Trypanosoma brucei. Kinetoplastids have diverged early on in evolution from the metazoan and fungal lineages and have developed distinct mechanisms in gene expression and other molecular processes, which are not only interesting from a mechanistic point of view, but which also have the potential to being exploited for anti-parasitic therapy. Based on a multidisciplinary approach including x-ray crystallography, x-ray footprinting, and mass spectrometry, I will present a mechanism of histone H3 lysine K76 methylation by T. brucei DOT1 enzymes distinct from that of human and yeast homologs, providing insight into the evolution, regulation, and function of kinetoplastid DOT1 methyltransferases.

Hosted by: Vivian Stojanoff

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