Tuesday, May 31, 2005, 11:00 am — John Dunn Seminar Room, Bldg. 463
Recent progress has been made in the assessment of radiation-induced damage to cellular damage upon exposure to gamma rays and several heavy ions that differ widely by their LET values. High performance liquid chromatography associated with tandem mass spectrometry has been used to monitor the formation of 12 oxidized bases and nucleosides including a recently discovered clustered lesion. It was found that 12C6+ ions are on the average two-fold less efficient in generating base damage than gamma rays. Further information on the formation of three main classes of radiation-induced DNA modifications including DNA strand breaks and DNA N-glycosylase-sensitive sites (oxidized pyrimidine and altered purine bases) was also gained from experiments that have involved the use of a modified alkaline comet assay. Interestingly the measurements of the lesions that are formed in a linear dose dependence manner were performed within the dose range (0.1 – 0.5 Gy). The overall data emphasize, at least indirectly, the major role played by clustered DNA damage in the biological effects of gamma rays and heavy ions.
Hosted by: Besty Sutherland
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