Thursday, December 22, 2005, 11:00 am — John Dunn Seminar Room, Bldg. 463
One of the most important challenges for computational biophysics is the accurate prediction of biomolecular structure and dynamic behavior. The major obstacles to quantitative agreement with experiment are accuracy of the energy function and the relatively slow timescale of conformational changes. This seminar will provide an overview of these challenges, and highlight recent work in both areas by the Simmerling lab. In addition, a series of examples will illustrate how energy functions that have been trained on peptide models can be used for the study of much larger systems. These examples include studies of active site flap dynamics and drug binding in HIV-1 protease and modeling of new enzyme inhibitors for the treatment of tuberculosis.
2698 | INT/EXT | Events Calendar
Not all computers/devices will add this event to your calendar automatically.
A calendar event file named "calendar.ics" will be placed in your downloads location. Depending on how your device/computer is configured, you may have to locate this file and double click on it to add the event to your calendar.
Event dates, times, and locations are subject to change. Event details will not be updated automatically once you add this event to your own calendar. Check the Lab's Events Calendar to ensure that you have the latest event information.