Monday, September 10, 2007, 10:00 am — John Dunn Seminar Room, Bldg. 463
Besides iron and zinc copper is another transition metal of high biological relevance. Copper is important in catalysis of redox reactions due its ability to be present as Cu(I) and Cu(II). However, because of this ability and the high reactivity of Cu(I), copper levels within a cell have to be regulated carefully to prevent cell damage. In Escherichia coli there have been three chromosomal determinants (copA, cueO (both regulated by cueR) and cusRS cusCFBA) identified involved in maintaining this balance. The cus system encodes for a two component regulatory system and a CBA efflux complex as well as an additional periplasmic protein CusF essential for full function. Recent biochemical and structural provide insight into the role of this unique protein.
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