Thursday, January 24, 2008, 11:00 am — John Dunn Seminar Room, Bldg. 463
DNA polymerases lambda and mu are involved in repair of double strand breaks through the non-homologous end joining pathway. To participate in this pathway, these polymerases must cope with non canonical DNA substrates, and this imposes substantial constrains on the architecture of their active sites. We have used x-ray crystallography to analyze the structure of these proteins, with an emphasis on how they interact with DNA in a manner that makes them effective for the NHEJ process.
Hosted by: Bob Sweet
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