Life Sciences Seminar

"Toxicogenomics of an Environmental Disease"

Presented by Arthur Grollman, Laboratory of Chemical Biology, Department of Pharmacological Sciences, Stony Brook University

Thursday, May 15, 2008, 11:00 am — John Dunn Seminar Room, Bldg. 463

An interdisciplinary approach (chemistry, molecular/cell biology and functional genomics) was used to establish the molecular and genetic mechanisms by which aristolochic acid exerts its profound nephrotoxic and genotoxic effects in humans. We have identified several genes involved in the cytotoxic effects of this ubiquitous phytotoxin on human renal proximal tubular and urothelial cells. Molecular epidemiologic and toxicogenomic methods have been used to investigate the etiology of endemic nephropathy and its associated urothelial cancer (PNAS, 104:12129, 2007), and to identify genes that confer susceptibility and resistance to this devastating environmental disease.

Hosted by: Carl Anderson

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