National Synchrotron Light Source Seminar

"DNA Cutting Molecular Scissors: From the Bench to the Bedside"

Presented by Eva Scheuring-Vanamee, Mount Sinai School of Medicine, New York

Friday, June 6, 2008, 12:00 pm — Seminar Room, Bldg. 725

Restriction endonucleases that are part of the restriction-modification system of bacteria serve as a paradigm for the site-specific cleavage of DNA. Since their discovery of more than three decades ago, they have become ubiquitous tools in molecular biology. Recent developments in creating artificial nucleases with tailored specificities have opened the door for new applications, including therapeutic gene targeting. The talk will focus on discussing the remarkable diversity and possible evolution of restriction enzymes, the structural factors that are responsible for their tight specificity, and possible ways to design enzymes with new specificities.

Hosted by: Vivian Stojanoff

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