Biology Department Seminar

"Validating Computational Models Using Global Regression Analysis"

Presented by Mikhail Levin, Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT

Friday, July 11, 2008, 11:00 am — John Dunn Seminar Room, Bldg. 463

Computational modeling is critical for quantitative understanding of biological systems. Building an accurate model requires global analysis of many experiments that explore a range of different behavioral aspects of a system. To facilitate global analysis, I have designed gfit (http://gfit.sf.net), open-source software that provides a general solution for connecting a heterogeneous dataset to a computational model. The program has been used for analyzing data from various experiments performed in vitro and in live cells. During the seminar I will discuss its applications to study DNA polymerase kinetics, thermodynamics of helicase - DNA complex, and the mechanism of nuclear transport.

Hosted by: Bill Studier

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