Friday, September 26, 2008, 11:00 am — John Dunn Seminar Room, Bldg. 463
Regulation of metabolic pathways requires the integration of signals at multiple levels. Our work on thiol metabolism in plants reveals strategies for how supramolecular processes control cellular biochemistry. In cysteine biosynthesis, a key regulatory feature is the association of serine acetyltransferase and O acetylserine sulfhydrylase into a macromolecular complex that coordinates sulfur assimilation and cysteine production in response to metabolic demands. Likewise, in glutathione biosynthesis, which acts to prevent oxidative damage, a thiol-based sensing system provides a mechanism for modulating glutamate-cysteine ligase activity in response to oxidation state. Ultimately, supramolecular regulation of metabolic pathways by sensing of cellular conditions may be more common and important than previously believed.
Hosted by: Chang-Jun Liu
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