Pegram Lecture

"Controlling the Cell Cycle"

Presented by Paul Nurse, The Rockefeller University

Wednesday, March 18, 2009, 11:00 am — Berkner Hall Auditorium

The growth and reproduction of all living organisms are dependent on the cell cycle, the process which leads to cell division. Uncontrolled division of cells is important for disease particularly cancer. Two events, S-phase and mitosis, are common to all cell cycles and are necessary for the two newly divided cells to receive a full complement of genes. The onset of S-phase and mitosis are controlled by cyclin dependent kinases in all eukaryotes studied from yeast to human beings. Checkpoint controls working through the CDKs block cell cycle progression if cells are too small or DNA is damaged or incompletely replicated. Recent results from the laboratory on these cell cycle controls will be described.

Hosted by: Peter Wanderer

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