Friday, April 3, 2009, 11:00 am — John Dunn Seminar Room, Bldg. 463
The seminar will deal with the functions of the Prep1 homeodomain transcription factor. A Prep1 null mutation in mouse leads to early embryonic lethality prior to gastrulation. Studies in hypomorphic Prep1 mice (Prep1i/i) show that Prep1 is a tumor suppressor gene. Indeed, human tumors show at very high (75%) frequency silencing of the gene. Prep1-deficient mouse cells show chromosomal abnormalities, basal DNA double strand breaks but normal DNA repair. Molecular insights into these phenotypes will be described.
Hosted by: Walter Mangel
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