Friday, April 17, 2009, 11:00 am — John Dunn Seminar Room, Bldg. 463
Hepatitis delta virus (HDV) is a satellite virus that infects a host only in the presence of its master virus, the Hepatitis B virus (HBV). Hepatitis delta virus uses host RNA polymerase to make a multimeric linear RNA. The ribozyme on the viral genome performs a self-cleavage reaction and releases the unit-length molecules from the nascent transcripts. The catalysis appears to follow a general acid-base mechanism in which a metal ion and a critical cytosine are involved. However, the role the divalent metal ions play in the catalysis has been controversial. I will describe how I have solved this controversy via a multi-pronged approach.
Hosted by: Huilin Li
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